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Doxycycline for Acne: Everything to Know

Find out if this commonly prescribed antibiotic is right for you

Dosage and How To
Contraindications
Possible Side Effects
Interactions
Alternatives

Doxycycline is an antibiotic that can be used to treat acne . As part of a group of antibiotics called tetracyclines , it helps treat acne by reducing bacteria on pores and by calming inflammation .

Doxycycline is commonly prescribed in pill or capsule form either as a generic medication or under the brand names Doryx, Vibramycin, Oracea, Adoxa, and others. When prescribed for acne, healthcare providers usually recommend taking it for about three to four months.

This article explains what doxycycline can (and cannot) do, how it should be used, and what side effects you might expect while taking it.

Illustration by Michela Buttignol for Verywell Health

Doxycycline Uses

Doxycycline is an oral antibiotic taken by mouth that is used to treat moderate to severe inflammatory acne . It can also be used to treat mild inflammatory acne that isn’t getting better with other treatments.

Inflammatory acne is the type in which bacteria inside a pore cause a red, swollen, pus-filled bump ( pustule ) on the skin. Cystic acne and nodular acne are two types of inflammatory acne.

Doxycycline works by reducing the amount of bacteria, most commonly Cutibacterium acnes , in skin pores. By controlling the infection, doxycycline also eases inflammation, including signs of redness and swelling.

As an oral drug, doxycycline is a good choice if you have an acne breakout on the back or other parts of the body that are difficult to reach with topical drugs.

Doxycycline is far less effective in treating non-inflammatory acne conditions like whiteheads (closed comedones ), blackheads (open comedones), or milia (subdermal cysts).

Doxycycline Dosage and How to Use

You'll need a prescription from your healthcare provider to take doxycycline. Doses vary from as low as 40 milligrams (mg) once daily to 100 mg twice daily.

Doxycycline is typically prescribed alongside topical retinoids and benzoyl peroxide . As doxycycline treats the underlying infection, the other drugs inhibit processes that contribute to pimples. Topical retinoids like Differin (adapalene) are especially good at unblocking clogged pores, while benzoyl peroxide helps shed dead skin cells that contribute to pore blockages.

Using doxycycline alongside these topical drugs also reduces the risk of antibiotic resistance as less doxycycline is used over a shorter period of time to achieve skin clearance.

Duration of Use

When indicated, doxycycline is typically used for three to four months. Your healthcare provider will take you off the drug once your skin has improved. You’ll then stay on topical treatments long-term to keep breakouts away.

People with especially severe cystic or nodular acne may need to use doxycycline for longer periods of time. Each case is assessed individually, weighing the benefits against the risks.

Regular follow-up appointments will be scheduled to check if the drug is working or if you need a different type of treatment.

Click Play to Learn More About Doxycycline Acne Treatments

This video has been medically reviewed by Casey Gallagher, MD .

Who Should Not Take Doxycycline

Doxycycline is not a one-size-fits-all solution for acne and may not be suitable for certain groups. This includes:

Pregnant people : Doxycycline can affect bone growth in a developing fetus and is not recommended if you are pregnant or breastfeeding.
Younger children : Doxycycline shouldn't be used by children under 8 years of age as it may affect bone growth and cause permanent tooth staining.
People with an allergy : You need to avoid doxycycline if you are allergic to other tetracycline antibiotics like chlortetracycline, oxytetracycline, demeclocycline, lymecycline, methacycline, minocycline, or rolitetracycline.

If doxycycline cannot be used, other oral or topical antibiotics like erythromycin can be prescribed.

Doxycycline Side Effects

Like all medications, doxycycline can cause side effects . While most are relatively mild and manageable, some people may experience profound or intolerable symptoms.

Possible side effects of doxycycline include:

Nausea or vomiting
Loss of appetite
Rectal itching
Vaginal redness, burning, or itching
Vaginal discharge
Painful urination
Difficulty urinating
Sore throat or nose
Swollen tongue
Changes in skin or nail color

Call your healthcare provider if you experience any unusual side effects or if side effects are becoming intolerable.

Upset Stomach and Diarrhea

Doxycycline can cause nausea and stomach upset. Taking the pill with food can help, but avoid dairy which can interfere with the absorption of doxycycline and make it less effective. When taking doxycycline, wait at least an hour before drinking or eating any dairy product.

Dairy may also cause acne because of hormones in milk products. One theory is that dairy foods increase inflammation in the body, leading to worse breakouts.

Esophagus Pain

Doxycycline can irritate your esophagus (the tube connecting your throat to your stomach). This can not only make it harder to swallow but also trigger acid reflux and heartburn .

You can reduce the risk by taking the pill with a big glass of water. Also, avoid lying down for about an hour after taking a dose.

Sensitivity to Sunlight

Doxycycline can make the skin more sensitive to the sun, referred to as photosensitivity . Symptoms include a skin rash, itching, and redness as well as an increased risk of sunburn. It can also cause photophobia in which your eyes are extra-sensitive to sunlight.

If prescribed doxycycline, always use sunscreen and reapply it often when spending time outdoors. You should also protect your eyes with sunglasses.

Can Doxycycline Make You Fat?

It's possible that doxycycline can cause weight gain with long-term use. Studies suggest this could be due to the antibiotic's effect on gut bacteria , causing the loss of "good" bacteria that can affect digestion. However, more research is needed.

Doxycycline Interactions

Doxycycline can interact with many drugs and supplements and affect how they work. These include:

Accutane (isotretinoin) : used to treat nodular acne
Antacids containing magnesium, aluminum, or calcium
Anticoagulants ("blood thinners") like Coumadin (warfarin)
Bismuth subsalicylate such as Pepto-Bismol or Kaopectate
Calcium supplements
Dilantin (phenytoin) : used to treat epilepsy
Iron supplements
Lamictal (phenobarbital): used to treat epilepsy
Laxatives containing magnesium
Proton pump inhibitors (PPIs) like Nexium (esomeprazole), Prilosec (omeprazole), or Protonix (pantoprazole)
Soriatane (acitretin) : used to treat psoriasis
Tegretol (carbamazepine) : used to treat seizures and chronic pain

Some interactions can be overcome by separating doses by two to three hours, particularly those containing calcium, magnesium, iron, or aluminum. Other drugs may need to be substituted or require a dose adjustment.

Let your healthcare provider know about any prescription or over-the-counter medications or supplements you take. This can help reduce the risk of a drug interaction.

Alternative Antibiotics for Acne

If you cannot take doxycycline for any reason, your dermatologist might prescribe an alternative antibiotic. According to the American Academy of Dermatology, effective alternatives include:

Azithromycin
Erythromycin
Minocycline
Tetracycline

Your dermatologist will work with you to determine the best option for you based on your symptoms and medication history.

How Much Does Doxycycline Cost?

The price of doxycycline can vary depending on the pharmacy and your health insurance. A 100-mg doxycycline generic typically costs between $8 and $13 for 20 capsules.

Doxycycline is an oral antibiotic that can be used to treat inflammatory acne when other treatments fail. It is taken by mouth for a short period of time to clear the underlying bacterial infection and help reduce inflammation. It is typically used in combination with other topical acne treatments.

Common side effects include nausea, diarrhea, sore throat, and changes in skin or nail color.

Woo YR, Lee SH, Cho SH, Lee JD, Kim HS. Characterization and analysis of the skin microbiota in rosacea: impact of systemic antibiotics . JCM . 2020;9(1):185. doi: 10.3390/jcm9010185

American Academy of Dermatology. Acne clinical guideline.

Kurokawa I, Nakase K. Recent advances in understanding and managing acne . F1000Res . 2020;9:F1000 Faculty Rev-792. doi:10.12688/f1000research.25588.1

Dréno B, Pécastaings S, Corvec S, Veraldi S, Khammari A, Roques C. Cutibacterium acnes ( propionibacterium acnes ) and acne vulgaris: a brief look at the latest updates . J Eur Acad Dermatol Venereol . 2018;32:5-14. doi: 10.1111/jdv.15043

American Academy of Dermatology. How long can I take an antibiotic to treat my acne?

Zaenglein AL, Pathy AL, Schlosser BJ, et al. Guidelines of care for the management of acne vulgaris . J Am Acad Dermatol . 2016;74(5):945-73.e33. doi:10.1016/j.jaad.2015.12.037

U.S. Food and Drug Administration. Doxycycline use by pregnant and lactating women.

Cross R, Ling C, Day NP, Mcgready R, Paris DH. Revisiting doxycycline in pregnancy and early childhood--time to rebuild its reputation ? Expert Opin Drug Saf. 2016;15(3):367-82. doi:10.1517/14740338.2016.1133584

Martins AM, Marto JM, Johnson JL, Graber EM. A review of systemic minocycline side effects and topical minocycline as a safer alternative for treating acne and rosacea . Antibiotics . 2021;10(7):757 doi: 10.3390/antibiotics10070757

MedlinePlus. Doxycycline .

National Health Service (UK). How and when to take doxycycline .

American Academy of Dermatology. Can the right diet get rid of acne ?

Velušček M, Bajrović FF, Strle F, Stupica D. Doxycycline-induced photosensitivity in patients treated for erythema migrans . BMC Infect Dis. 2018;18(1):365. doi:10.1186/s12879-018-3270-y

Angelakis E, Million M, Kankoe S, et al. Abnormal weight gain and gut microbiota modifications are side effects of long-term doxycycline and hydroxychloroquine treatment. Antimicrobial Agents Chemother 2014;58(6):3342-3347. doi:10.1128/aac.02437-14

Costco Wholesale. Doxycycline hyclate (generic).

Oge L, Broussard A, Marshall M. Acne vulgaris: Diagnosis and treatment . American Family Physician. 2019 Oct 15;100(8):475-484

Zaenglein AL, Pathy AL, Schlosser BJ, et al. Guidelines of care for the management of acne vulgaris . Journal of the American Academy of Dermatology. 2016 May;74(5):945-73.e33.

By Angela Palmer Angela Palmer is a licensed esthetician specializing in acne treatment.

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Doxycycline Is the Acne-Fighting Antibiotic Derms Want You to Know

Melanie Rud is a Chicago-based writer with 10 years of experience covering beauty. She covers all things skincare for Byrdie, from ingredients to acne advice.

In This Article

There's no shortage of acne treatments and products formulated for those with acne-prone skin . Patches, washes, scrubs, peels—take your pick. Still, as anyone who has ever dealt with severe acne (we're not talking about the occasional breakout here and there) will tell you, sometimes over-the-counter skincare products don't cut it. In that case, dermatologists will try combating the condition from the inside out, where oral medications like doxycycline come into play.

There are several different options skin docs commonly rely on, ranging from hormonal therapies ( birth control pills , spironolactone ) to antibiotics. Among the latter, doxycycline—or doxy, as it's often referred to—is one of the most popular, often-prescribed pills out there, as it works to reduce inflammation and lower levels of acne-causing bacteria. But before you head to the pharmacy, we tapped expert dermatologists Joshua Zeichner, MD, and Jordan Carqueville, MD, to answer all your questions about taking doxycycline for acne.

Ahead, discover how doxycycline works as well as its benefits and potential side effects.

Meet the Expert

Joshua Zeichner , MD, is a board-certified dermatologist and assistant clinical professor of dermatology at Mount Sinai Hospital in New York City.
Jordan Carqueville , MD, is a board-certified dermatologist and dermatopathologist in Chicago, specializing in general, surgical, and cosmetic dermatology.

Doxycycline

Type of ingredient: Anti-inflammatory

Main benefits: Commonly used for bacterial infections and treatment of moderate to severe acne

Who should use it: Those dealing with inflammatory acne on larger areas of the body

How often can you use it: Varies from patient to patient

Works well with: Oral doxy works well in tandem with products containing benzoyl peroxide , but consult a doctor first before use.

Don’t use with: N/A

What Is Doxycycline?

Doxycycline is an antibiotic in the tetracycline family commonly used to treat various bacterial infections and moderate to severe acne. The 'moderate to severe' part is key here, according to Zeichner, as this is not (nor is any oral antibiotic) a go-to treatment for a few clogged pores or acne types like blackheads . It should only be considered for those suffering from inflammatory acne; in other words, widespread, red, angry pimples, notes Zeichner. It's also beneficial for those dealing with acne on larger areas of the body—think chest and back acne —and for patients who aren't responding to topical medications alone, he adds.

Its mechanism of action against acne is similar to that of other tetracycline antibiotics, the most common being minocycline . That being said, "doxycycline is the most commonly used oral antibiotic for acne due to its low side effect profile and efficacy in treating inflammatory acne," says Carqueville. Zeichner agrees: "It's an effective drug that has been used in dermatology for decades and has a proven safety record." Doxycycline is the generic name of the drug, by the way, and name brands include Vibramycin, Mondox, Atridox, and Doryx, to name a few.

How It Treats Acne

So, how exactly does it help combat blemishes? "Doxycycline treats acne in both direct and indirect ways," says Zeichner:

Lowers levels of acne-causing bacteria: The medication directly lowers the levels of acne-causing bacteria ( p.acnes) on the skin. Like the other tetracyclines, it does this by inhibiting the protein synthesis of this bacteria, explains Carqueville. The additional benefit of this? Zeichner points out that reduced bacterial levels also reduce subsequent inflammation in the skin.

Impacts the immune system: Doxy also reduces inflammation more directly via its effects on the immune system . "It blocks the recruitment of inflammatory blood cells and enzymes and messengers that drive skin inflammation," Zeichner explains. This double-whammy of anti-inflammatory benefits is why this drug reduces the redness and tenderness of active pimples, adds Carqueville.

You'll first have to get a prescription from your dermatologist. It's crucial only to take this medication under the direct guidance of a dermatologist, as it can have some serious side effects (more on that below).

"The dosage and duration of treatment may vary from patient to patient, but typically, you can expect to be on the medication for at least six to eight weeks. The dosage is usually 50 to 100 milligrams, taken once or twice daily," says Carqueville. Doxycycline can have some gastrointestinal side effects, so both dermatologists we spoke with also advise taking the medication with a full glass of water. Also important: Take it at least 30 minutes, if not an hour, before lying down to minimize the risk of developing heartburn. It's a no-no if you're pregnant or breastfeeding, as well as for anyone who is allergic to tetracyclines.

Zeichner also suggests talking to your dermatologist about combining oral doxy with a product that contains benzoyl peroxide, a topical ingredient that also has antibacterial activity against p.acnes— this can help limit the development of bacterial resistance, he adds. And to that point, keep in mind that this isn't going to be a long-term treatment. While you need to be on it for several weeks to see effects, "it should be limited to three or four months of use and discontinued as soon as possible," cautions Zeichner. This is the general rule of thumb for any oral antibiotic being used as an acne treatment, again, to minimize the likelihood of bacterial resistance. Once you're off of it, topical treatments should be enough to maintain the results achieved. If not, your dermatologist will likely suggest an alternative oral drug, such as hormonal therapy or a heavy-duty medication called isotretinoin, Zeichner says.

Potential Side Effects

Acid reflux (aka heartburn) is one of the most significant potential side effects. "Doxycycline can cause inflammation of the esophagus and, in severe cases, even lead to ulcers," says Zeichner. Nausea and vomiting are also possible side effects, as is increased sun sensitivity, so be extra diligent about your sun protection practices, advises Carqueville. Still, it's worth noting that even though studies found both doxycycline and minocycline to be effective acne treatments, the side effect profile is theoretically safer and more tolerable with doxy, according to Carqueville. (She adds that while there tend to be fewer GI symptoms that come with minocycline, it may be associated with rare hypersensitivity reactions and ringing in the ears, which aren't side effects of doxycycline.) In other words, while this may sound like a long list of potentially unpleasant side effects, at the end of the day, doxycycline is still considered to be a top-notch, safe, and effective oral antibiotic for acne.

Doxycycline can also be used to treat rosacea , cellulitis, and skin infections.

When taking doxycycline for acne, you should drink a lot of water to help with digestion, make sure you're taking it with a meal, wear SPF daily, and avoid lying down right after taking the medication.

Typically, you should be taken off the medication once your skin improves but it's best to consult your healthcare professional.

Del Rosso JQ. Oral doxycycline in the management of acne vulgaris: current perspectives on clinical use and recent findings with a new double-scored small tablet formulation. J Clin Aesthet Dermatol . 2015;8(5):19-26.

Xu H, Li H. Acne, The Skin Microbiome, And Antibiotic Treatment . Am J Clin Dermatol . 2019;20(3):335-344.

Krakauer T, Buckley M. Doxycycline Is Anti-Inflammatory And Inhibits Staphylococcal Exotoxin-Induced Cytokines and Chemokine s. Antimicrob Agents Chemother . 2003;47(11):3630-3633.

Doxycycline (Oral Route) Side Effects - mayo clinic.

Doxycycline (Oral route) Proper Use - mayo clinic.

Kircik LH. Anti-inflammatory dose doxycycline plus adapalene 0. 3% and benzoyl peroxide 2. 5% gel for severe acne. J Drugs Dermatol . 2019;18(9):924-927.

Zaenglein AL, Pathy AL, Schlosser BJ, et al. Guidelines of care for the management of acne vulgaris . Journal of the American Academy of Dermatology . 2016;74(5):945-973.e33.

What is doxycycline?

Doxycycline is the most commonly prescribed oral antibiotic acne treatment. It’s also used to treat rosacea and skin infections.

As an oral antibiotic, doxycycline is taken in pill form. It’s not available over-the-counter, only through a prescription for your dermatologist or doctor.

Doxycycline belongs to a larger group of bacteria-fighting drugs called tetracycline antibiotics, which also includes minocycline and oxytetracycline. These are often prescribed for the management of acne.

Common brand names of doxycycline include Doryx, and Vibramycin, though there are others on the market. Due to the strength and effectiveness of this treatment option, it is usually reserved for moderate to severe acne.

How Doxycycline Treats Acne

Cutibacterium acnes (previously known as Propionibacterium acnes ) is the bacteria that causes acne breakouts on the skin. Acne is not the result of a skin infection; however, the more C. acnes that sits on your skin, the more likely you are to get pimples.

Doxycycline (also called doxycycline hyclate ) kills C. acnes , which lives in the oil-producing glands of your skin. Doxycycline may also reduce existing inflammation, another feature of acne.

Dermatology is still learning more about the anti-inflammatory properties of how doxycycline treats acne.

Treatment of acne with doxycycline is best indicated for pustules and red bumps seen in inflammatory acne. Blackheads and whiteheads respond better to other treatments.

How long should you take doxycycline for acne? You should take doxycycline for acne until your symptoms visibly improve. This antibiotic is not a permanent prescription but rather a temporary fix as you work with your dermatologist on ways to manage your skincare.

Dosage of Doxycycline for Acne

The dosage of doxycycline for acne varies by patient, but I typically recommend starting at a low dosage. Some doctors recommend 100mg a day or even twice a day, but I find that the side effects and impact on your microbiome are much more severe with this larger dose.

A doxycycline dosage of between 20-50 mg daily is a good place to start. Since this acne medication can wipe out your natural bacteria levels, continue to take a probiotic for acne to retain some of your body’s helpful microorganisms.

What to Expect When Taking Doxycycline

Picture this: you walk into your dermatologist’s office, having just read this inspiring article about how doxycycline might work for you. After explaining any other conditions or medications, and assessing the severity of your acne, they decide that doxycycline for acne is a good fit for you.

You’ll start taking your low dose right away, being sure to pair it with a meal and a large glass of water to avoid adverse effects. You’ll need to buy some chic hats and stay in the shade to keep your skin safe, so choose a shady spot for your weekly brunch catchup with the girls.

Some say that their acne got worse before it got better on doxycycline, but for most, this stage is short if it happens at all. In 4-6 weeks, you’ll head back to your dermatologist to check your skin’s progress at the halfway point in your medication.

Your dermatologist will check how your skin is reacting to the prescription and re-evaluate your dosage. It’s worth asking if you can lower your dose at this stage. From there, you can work with your doctor on long-term solutions to keep acne breakouts away.

How long does it usually take for doxycycline to work?

How long does it take for antibiotics to clear up acne? It takes antibiotics like doxycycline in between 2 weeks and 3 months to clear up acne.

How long does it usually take for doxycycline to work? Doxycycline takes 4-6 weeks to show a visible difference on severe or moderate acne. Around this time, your dermatologist will check in on your progress using the prescription.

Doxycycline Side Effects

Doxycycline can have many side effects, some common or mild and some quite severe.

A study published in the Journal of the American Academy of Dermatology found that doxycycline had less harsh adverse effects than its counterpart, minocycline. However, there are still some issues to look out for.

Some of the most common side effects of doxycycline include:

Photosensitivity (sensitivity to light). This can cause sunburns and sun damage to the skin. You’ll need to be careful to wear adequate sunscreen and avoid long periods of sun exposure while taking doxycycline.
Heartburn . Doxycycline sometimes causes esophagitis, or inflammation of the esophagus. This can lead to heartburn. Take your pill directly after a meal with a full glass of water to avoid unnecessary irritation. You’ll also want to avoid lying down for 30 minutes after your dose.
Gastrointestinal issues . Nausea, vomiting, and diarrhea are all possible side effects of doxycycline (and most antibiotics). Let your dermatologist know if these are ongoing or serious. As mentioned above, be sure to take your pill with a meal to avoid these symptoms.

However, oracea is one form of doxycycline that should only be taken on an empty stomach, so chat with your prescriber if you’re concerned about how to take your medicine.

Serious, more rare side effects of doxycycline include:

Tooth staining . When small children or pregnant women take doxycycline , it can cause serious, irreversible discoloration of teeth . Therefore, doxycycline is not prescribed for pregnant women or children who have not gotten all of their permanent teeth. After all of your permanent teeth are in (usually by age 8-10), you don’t not need to worry about potential tooth staining from tetracycline antibiotics.
Antibiotic resistance . This is a serious condition that prevents antibiotics from working in your body in the future. Using a topical medication like benzoyl peroxide or topical retinoids may reduce the chances of developing this condition. This is also why dermatologists limit how long you can use oral antibiotics as a treatment option.
Ulcers in the esophagus . If esophagitis persists, ulcers (painful sores) can develop in the esophagus, causing more pain and making swallowing difficult. Taking your doxycycline with food helps prevent this issue.

Drug Interactions

While doxycycline can do miracles for acne, it doesn’t always play well with others.

Doxycycline hyclate should not be taken at the same time as:

Antacids with calcium , like Tums, can prevent your body from absorbing doxycycline appropriately.
Iron supplements can also block optimal absorption.
Penicillin has a known interference with doxycycline.
Warfarin can increase the side effects of doxycycline.

If you take any of these drugs or supplements, notify your doctor before starting doxycycline for acne.

Is doxycycline right for you?

Doxycycline for acne is an effective treatment with years of documented success stories. However, there are possible risks and side effects involved and it’s not the right fit for everyone.

Pregnant women, small children, and people on medications listed above should probably not take doxycycline. It also won’t work for those with antibiotic resistance. This prescription is not a one size fits all, but it’s a great solution for a large number of acne patients.

In the end, your integrative dermatologist should be passionate about looking at the whole picture and getting you to your healthiest self. They should be able to give you the scoop on exactly what combination of medication is right for you in winning your war against acne.

Del Rosso, J. Q. (2015). Oral doxycycline in the management of acne vulgaris: current perspectives on clinical use and recent findings with a new double-scored small tablet formulation. The Journal of clinical and aesthetic dermatology, 8 (5), 19. Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445892/
McLaughlin, J., Watterson, S., Layton, A. M., Bjourson, A. J., Barnard, E., & McDowell, A. (2019). Propionibacterium acnes and acne vulgaris: new insights from the integration of population genetic, multi-omic, biochemical and host-microbe studies. Microorganisms, 7 (5), 128. Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560440/
Patel, R. S., & Parmar, M. (2020). Doxycycline Hyclate. In StatPearls [Internet]. StatPearls Publishing. Full text: https://www.ncbi.nlm.nih.gov/books/NBK555888/
Henehan, M., Montuno, M., & De Benedetto, A. (2017). Doxycycline as an anti‐inflammatory agent: updates in dermatology. Journal of the European Academy of Dermatology and Venereology , 31(11), 1800-1808. Abstract: https://pubmed.ncbi.nlm.nih.gov/28516469/
Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., … & Keri, J. E. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74 (5), 945-973. Abstract: https://pubmed.ncbi.nlm.nih.gov/26897386/
Cross, R., Ling, C., Day, N. P., McGready, R., & Paris, D. H. (2016). Revisiting doxycycline in pregnancy and early childhood–time to rebuild its reputation?. Expert opinion on drug safety, 15 (3), 367-382. Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898140/

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v.13(9); 2020 Sep

Oral Antibiotic Treatment Options for Acne Vulgaris

Acne vulgaris is the most common dermatological disease in the United States, affecting up to 85 percent of teenagers. While the American Academy of Dermatology has established guidelines regarding acne treatment in general, the variability among acne treatments, even within a given class, prevents establishment of a straightforward regimen. For example, moderate to severe acne is generally treated with an oral antibiotic, although several options are available—both across and within antibiotic classes. The aim of this review is to report the efficacy and safety data available for commonly prescribed oral antibiotics. While there are currently no data to support superiority of one drug over another, there are substantial differences in safety profiles and brand-specific features that may make one antibiotic preferable over another.

Acne vulgaris is the most common skin disorder encountered in dermatology practice in the United States, affecting approximately 85 percent of teenagers and sometimes persisting into and throughout adulthood. 1 – 3 Although not life-threatening, acne can have a significant adverse psychological and physical impact. 4 Many patients with acne report feelings of depression, anxiety, emotional stress, or poor self-image, and severe acne can lead to permanent scarring in up to 20 percent of cases. 4 , 5

Acne is a disease of the pilosebaceous unit with a complex pathology. Currently, there are thought to be at least four synergistic, biological mechanisms that contribute to acne pathogenesis, which is primarily inflammatory in nature. 6 , 7 These include increased sebum production, follicular hyperkeratinization, local inflammatory cascades, and microbial proliferation of Cutibacterium acnes (or C. acnes , formerly Propionibacterium acnes ). 8 , 9 The complex interplay of these biological pathways makes effective treatment of acne difficult. Nonetheless, there are a variety of therapeutics available, each targeting one or more of these pathogenic processes. 2 – 4

Pharmacological treatments for acne include a variety of topical and systemic agents. Topical treatment (e.g., benzoyl peroxide, antibiotics, and retinoids) is generally used as first-line treatment in cases of mild-to-moderate acne with comedonal lesions and inflammatory lesions. 4 Systemic treatment (e.g., oral antibiotics and hormonal therapy) can be used as first-line treatment in cases of moderate-to-severe acne, in combination with a topical agent. 2 , 4 While it is outside the scope of this review to discuss each treatment type in detail, Table 1 provides a summary of recommended treatment options. This review will focus on the efficacy and safety of oral antibiotics that are commonly used or available to treat acne.

Treatment algorithm for the management of acne vulgaris in adolescents and young adults 4

** indicates that the drug may be prescribed as a fixed combination product or as separate component

ORAL ANTIBIOTICS

The American Academy of Dermatology supports the use of oral antibiotics for treating moderate and severe acne, and oral antibiotics have been a mainstay of acne treatment for over 50 years. 4 It is well-accepted that antibiotics are efficacious in reducing acne severity and have an overall acceptable safety profile.

In recent years/decades, however, there has been growing concern regarding the development of antibiotic resistance. 10 As such, some previously employed antibiotics (e.g., erythromycin and clindamycin) are no longer used clinically because of their high rates of resistance. 11 The concern is serious enough that the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) now actively promote campaigns aimed to confront antibiotic resistance. 10 , 12 The CDC encourages antibiotic stewardship, which asserts that physicians must act responsibly when prescribing antibiotics, with the hope that this will limit the development and/or expansion of antibiotic resistance. 10 The WHO’s “global action plan” has five strategic objectives, aimed both at the community (e.g., improving awareness and understanding) and providers (e.g., optimizing use). 12

Apart from the tetracycline class of antibiotics (doxycycline, minocycline and sarecycline), the potential benefit of oral antibiotics often outweighs the potential risks, and they remain a mainstay of moderate-to-severe acne treatment. With currently available clinical studies and data, there is a consensus that no one antibiotic is superior to another regarding efficacy. 13 , 14 The safety profiles, however, differ considerably. 15 , 16 In this article, we will review previous research for several antibiotics currently used, including doxycycline, minocycline, azithromycin, and trimethoprim-sulfamethoxazole, and one recently introduced to the market, sarecycline. Studies included were those that evaluated treatment response in patients with acne.

Among acne studies, there are several metrics of efficacy that are commonly reported. 17 Perhaps most frequently used is the change in inflammatory lesions from baseline to endpoint, expressed as either absolute change or percent change. Similarly, the absolute or percent change in non-inflammatory lesions (i.e., open or closed comedones) might be recorded, although this is less common in studies of oral antibiotics, as they are generally more effective for inflammatory lesions. A common subjective measure is the investigator’s global assessment (IGA), which considers the quality and quantity of acne lesions. While the IGA is a five-point scale based on acne severity (ranging from 0=clear to 4=severe), results are generally dichotomized in trials such that a participant has IGA “success” (score of 0 or 1; clear or almost clear, respectively) or IGA “failure” (score >1). Change in inflammatory lesions will be the emphasis of efficacy results for this review.

This review will begin by summarizing studies of tetracycline-class antibiotics, followed by azithromycin and trimethoprim-sulfamethoxazole.

The tetracyclines. Among oral antibiotics used to treat acne, tetracycline has the longest history, having been discovered in the 1940s and FDA-approved in 1953. While effective, its side effect profile, need for frequent dosing, and susceptibility to antibiotic resistance have made it unpopular, and it is no longer considered a standard treatment regimen. 14 There are, however, several tetracycline derivatives that were chemically adapted to provide additional benefits. 11 Thus, this review will focus not on tetracycline as a drug, but rather on the individual drugs that fall within the tetracycline class (i.e., doxycycline, minocycline, and sarecycline).

Each of these “second-generation” tetracyclines share the same mechanisms of action (MOA); the chemical is transported into bacterial cells, binds the 30S unit of the ribosome, and inhibits protein synthesis. In addition to their antibacterial action, the tetracyclines demonstrate multiple anti-inflammatory properties. 18 The therapeutic effect of tetracyclines in acne might be due, at least in part, to reduction in neutrophil chemotaxis and inhibition of proinflammatory cytokines and matrix metalloproteinases. 19 The anti-inflammatory actions may be particularly important considering research by Jeremy et al 20 that showed inflammation is present far in advance of clinically recognizable lesions—known as the prelesional folliculocentric inflammatory phase. While all tetracyclines share these anti-microbial and anti-inflammatory MOAs, there is significant variability regarding side effect profiles, discussed below, that account for the preferential prescription of one over the other. 16 , 18 , 21

Doxycycline. The first tetracycline derivative to come to market was doxycycline, approved by the FDA in 1967 and still one of the most commonly used antibiotics in clinical practice. 14 , 22 Relative to its parent tetracycline, doxycycline is more lipophilic, making it optimal for penetrating and accumulating in the sebaceous gland—where C. acnes resides and proliferates. 11 Two formulations of doxycycline are available—doxycycline hyclate and doxycycline monohydrate, which are different salt forms of the same active drug. Doxycycline hyclate is more water-soluble than doxycycline monohydrate and might be more ulcerogenic and susceptible to causing gastrointestinal (GI)-associated side effects. 23 , 24 Their differences are more relevant for manufacturing purposes than for assessing efficacy, however. 25

The side effect profile of doxycycline is superior to that of tetracycline, although there are potential adverse events that should be taken into consideration ( Table 2 ). Most of doxycycline’s side effects are mild and/or can be prevented with proper measures. 14 Doxycycline is frequently associated with phototoxicity; it interacts with ultraviolet (UV) rays, making an individual more susceptible to severe sunburn. Gastrointestinal disturbance is a common side effect of doxycycline treatment and might present as nausea, vomiting, and/or diarrhea. Doxycycline is amenable to being taken with food—which might lessen GI discomfort— although its absorption is reduced by approximately 20 percent with food. 11 When it is taken to treat acne, however, this reduction in absorption is believed to have minimal clinical relevance. Pill esophagitis—inflammation or esophageal ulcers—can occur when taking doxycycline. Like other side effects, however, it is largely avoidable if patients take medication with a large glass of water and do not lie down shortly after ingesting medication. 14 Lastly, there is the potential for permanent tooth discoloration in individuals with developing teeth. This is a side effect shared by all tetracycline derivatives which are not recommended for children younger than eight years of age and women during pregnancy. 26 Similarly, all tetracyclines have been shown to impair bone growth by forming a stable calcium complex and thus should be avoided in children and during pregnancy. 27

Common side effects of oral antibiotics

*Insufficient data for verification at time of publication

**Vestibular adverse events are highest in immediate-release formulations of minocycline. Extended-release minocycline formulations display an adverse event profile similar to placebo. 36

Doxycycline has a long history of safe and effective treatment in acne patients. An early study by Plewig et al 28 (1970) evaluated the efficacy of doxycycline in 62 patients in a double-blind crossover study. A “good” or “excellent” response in the reduction of inflammatory lesions was reported in 33 percent of patients receiving doxycycline. Statistically, improvement from baseline was significant with doxycycline treatment, but not placebo. In a clinical study by Moore et al, 29 662 patients were randomized to one of three treatments—a 40mg dose of modified-release doxycycline, a 100mg dose of doxycycline, or placebo. After 16 weeks of treatment, reduction in lesion count and success rate were evaluated. For both outcome measures, doxycycline treatment was superior to placebo. Interestingly, the lower dose of modified-release doxycycline was more effective in reducing the number of overall lesions, suggesting that a large part of the efficacy of doxycycline stems from its role as an anti-inflammatory agent. 29

A review article that gathered results from tetracycline treatment studies for acne between 1962 and 2006 showed that doxycycline was consistently effective, although results were variable between studies. 17 The largest reduction in inflammatory lesions was 75 percent, and the lowest reduction in inflammatory lesions was 23 percent. 17 Efficacy results, reported as reduction in inflammatory lesions, are summarized in Table 3 .

Reduction in inflammatory lesions with various treatment times *

NA: not available

+TMP-SMX study did not evaluate absolute number of inflammatory lesions but rather a grade based on number and severity of lesions 56

*Doses may differ across studies

Due to the popularity of doxycycline, several brands are available, each boasting additional benefits aside from their efficacy in treating acne. Acticlate is available as a functionally scored tablet, and dosage can be easily modified without requiring a new prescription. 30 Doryx is enteric-coated, which makes it more resistant to breakdown by stomach acids. 31 There is also Doryx MPC (modified polymer coating), extends absorption even longer, potentially reducing GI-related side effects. 32 Targadox is the smallest branded doxycycline and does not require pill splitting. 33 Its excipients are gluten-free, lactose-free, vegan, and non-GMO, making it amenable to most patient dietary restrictions/ preferences. 33 All brands may be taken once daily with or without food.

Minocycline. Another tetracycline derivative, minocycline, was FDA-approved after doxycycline, in 1971, and continues to be a popular treatment option for moderate to severe acne. 14 , 22 Of the tetracyclines, minocycline is the most lipophilic, making it easily accessible for penetrating and accumulating in the sebaceous gland, where C. acnes colonizes. 11 The high absorption rate of minocycline is beneficial in multiple facets—it may be taken with food, which may increase patient adherence; lower doses are required; and less active drug remains in the GI tract, which might limit the disturbances commonly seen with doxycycline. Consumption with dairy products does not decrease the bioavailability of minocycline. Photosensitivity is rare with minocycline. Because the permeability of minocycline is so high, however, it is more susceptible to crossing the blood-brain barrier, which can promote acute vestibular adverse events, such as dizziness and vertigo. 11 , 14 In addition, although rare, there is the potential for severe adverse effects, like hyperpigmentation (sometimes irreversible), drug hypersensitivity, Stevens-Johnson syndrome, and autoimmune, lupus-like reactions ( Table 2 ). 26

In the last couple of decades, extended-release (ER) minocycline formulations have come to the market. Rather than the rapid absorption and high peak concentration seen with immediate-release (IR) minocycline, ER formulations regulate the rate at which minocycline is released and systemically available. 34 , 35 Although the efficacy for ER and IR minocycline is similar, reported severe adverse events are reduced with the ER formulation. 14 , 35

Unlike doxycycline and immediate-release minocycline, extended-release minocycline underwent traditional Phase III studies and has been evaluated in two randomized, double-blind, placebo-controlled trials. 36 Combined, 924 subjects received weight-based minocycline or placebo for 12 weeks, at which time two primary endpoints were assessed: mean percent change in inflammatory lesions and percentage of subjects with an Evaluator’s Global Severity Assessment (EGSA) of clear or almost clear. Across the two studies, mean percent improvement in inflammatory lesions ranged from 43.1 to 45.8 percent for minocycline, compared to 30.8 to 31.7 percent for placebo. 36 In patients treated with minocycline, 15.9 to 17.3 percent achieved success, compared to only 7.9 to 9.5 percent treated with placebo. 36 No effect was seen on non-inflammatory lesions. A review article that compiled results from minocycline (both immediate-release and extended-release) treatment studies for acne between 1962 to 2006 showed that, similar to doxycycline, the efficacy was quite variable between studies. 13 The most significant reduction in inflammatory lesions was 91 percent and the lowest reported reduction in inflammatory lesions was 22 percent.

The adverse events associated with immediate-release minocycline (primarily vestibular) have caused a surge in marketed extended-release minocyclines that are dosed based on patient weight. 35 Solodyn and Ximino are commonly prescribed, and MinoLira was most recently launched to the market. Solodyn was first to market with an extended-release formulation and was FDA-approved in 2006. 37 Ximino, approved in 2012, is the first and only extended-release minocycline available in a capsule form, which some people prefer to tablets. 38 MinoLira is the first dual-release minocycline tablet used for treating acne and was FDA-approved in 2017. 39 Each of the three brands promotes once-daily, weight-based dosing and can be taken with or without food.

Sarecycline. Sarecycline is the newest tetracycline derivative introduced into the market and was FDA-approved in 2018. As a tetracycline derivative, it shares the same protein synthesis inhibitory MOA as those previously described. However, sarecycline claims to be a narrow-spectrum antibiotic, which might lower the chance of developing antibiotic resistance. 3 , 40 Recently, it was shown that C. acnes strains displayed a low propensity for the development of resistance to sarecycline, with a spontaneous mutation frequency being 10- 10 at 4-8 X MIC. Clinical relevance has yet to be explored. 40 Sarecycline is also indicated to treat acne in patients as young as nine years of age, whereas other tetracyclines lack this indication. 41 Thus, sarecycline treatment might be preferred in young children, although it is important to note that children aged 9 to 12 comprised only one percent of the clinical study population, and additional research is warranted. 42 Sarecycline comes with the same warnings of tooth discoloration and impaired bone growth as other tetracycline derivatives. Like minocycline, its dosing is weight-based, once-daily, and can be taken with or without food. 41

In its Phase II clinical trial evaluating 285 patients, after 12 weeks of 1.5mg/kg treatment, inflammatory lesions were reduced by 52.7 percent, compared to 38.3 percent in placebo-treated patients. 43 Two larger, identically designed Phase III clinical trials of 1,702 completed patients also showed an approximate 50-percent reduction in inflammatory lesions, compared to approximate 35-percent in placebo-treated patients. 44 Additionally, 22 percent of participants achieved IGA success at 12 weeks. 44 The drug was generally well-tolerated with minimal side effects in comparison to placebo.

Seysara is the first and only sarecycline available.

Azithromycin. Unlike any previously discussed antibiotics, azithromycin is a macrolide antibiotic. Macrolides also inhibit protein synthesis, although in a different way from tetracyclines—by binding the 50S subunit of the ribosome. 45 Azithromycin is a derivative of erythromycin. As mentioned previously, erythromycin was once used as an effective acne therapy, but widespread antibiotic resistance has rendered it less useful. 3 , 11 Azithromycin is used to treat serious systemic infections, and its use for acne is generally reserved for select cases, such as in patients for whom tetracyclines are contraindicated. 46

An important differentiator of azithromycin from other antibiotics is its safety profile during pregnancy and lactation ( Table 2 ). Animal studies show that the drug crosses the placenta but is not associated with fetal harm. 47 Thus, this may be the preferred treatment if pregnancy must be taken into consideration. 48 Additionally, azithromycin has rapid uptake from circulation, followed by a slow release. 49 The extended half-life is conducive to less frequent dosing, which might improve adherence. 50 The bioavailability of azithromycin is decreased when taken with food.

Papers evaluating the efficacy of azithromycin date back to 1997. The case series included only three patients, and in each patient, azithromycin reduced total number of inflammatory lesions. 51 A larger trial (N=64) examining different azithromycin doses supported the early findings. The Global Acne Grading System was the outcome measure, and for all doses, mean acne score significantly decreased at the end of the first (30%–33%), second (46%–50%), and third month of treatment (70%–76%) when compared to baseline. 52 Numerous dosing regimens have been recommended since then, some of which call for infrequent dosing, which might be more convenient for patients. 3

There are no specific brands marketed for the treatment of acne.

Trimethoprim/sulfamethoxazole (TMP-SMX). TMP-SMX was approved by the FDA in 1973. The two antibiotics work synergistically to inhibit folate synthesis in bacteria. 53 While not indicated for acne, it is frequently used off-label. 54 Because it is the agent most commonly used to treat adults with community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections, it should be used sparingly due to the concern of antibiotic resistance.

TMP-SMX is also reserved for third-line therapy due to the possibility of rare, though severe and potentially life-threatening, adverse events, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). 53 TMP-SMX is one of the few medications considered “high” risk for inducing SJS or TEN, and risk is highest when the drug has been recently initiated and in patients infected with HIV. 3 , 55 In both diseases, severe epidermal necrosis causes extensive skin detachment and is life-threatening. 55

Data regarding the use of TMP-SMX in treating acne are limited. However, a double-blind study of 43 patients by Hersle 56 (1972) showed that the acne score (a calculation by the authors based on lesion number and severity) decreased by 62 percent after just five weeks of treatment with TMP-SMX, compared to 9 percent in placebo-treated patients. TMP-SMX might be particularly effective in treating in patients with acne who were refractory to tetracycline treatment. 53 , 57

While TMP-SMX treatment of acne is off-label, two brands are commonly used: Bactrim and Septra. Both are also available as a double-strength formulation. There are no features that would suggest superiority of one brand over the other.

HEAD-TO-HEAD TRIALS

A systematic review by Simonart 17 evaluated randomized trials and was designed to specifically compare the efficacy of different tetracyclines. The review, however, reported no significant difference in number of either inflammatory (n=32 trials) or non-inflammatory (n=23 trials) lesions. A randomized, double-blind study by Olafsson 58 compared doxycycline and minocycline treatment effect in 64 patients with acne over 12 weeks. A significant reduction in all types of acne lesions (pustules, papules, open comedones, and closed comedones) was observed at 12 weeks, and doxycycline and minocycline were found to be equally effective. Similarly, a meta-analysis by Kim 48 evaluated results from six trials that compared oral azithromycin pulse therapy and doxycycline daily therapy. Four outcome measures were compared at 12 weeks: remaining inflammatory lesions, remaining non-inflammatory lesions, patients’ self-assessment, and investigators’ assessment. In each case, there was no significant difference between groups. Even after a sensitivity analysis was conducted to account for potential bias, neither outcome measure—inflammatory lesions nor investigators’ assessment—significantly differed between groups. 48

An extensive minocycline-focused Cochrane review published in 2012 concluded that minocycline is an effective treatment for moderate to moderately severe acne, but there was no evidence that it is better than other commonly used acne treatments, including oral doxycycline or macrolide antibiotics. 13 Reviews by Del Rosso 14 and Kircik 21 similarly concluded that doxycycline and minocycline display a similar efficacy to one another. Studies have compared azithromycin to either doxycycline or minocycline. 14 , 21 , 59 In each case, both drugs were deemed effective and there were no significant group differences. 45 , 60

Comparative trials with TMP-SMX are limited because it is used off-label and as a third-line agent. Sarecycline has not yet been studied as a direct comparator to any other oral antibiotic.

At present, doxycycline, minocycline, and sarecycline are are the most commonly prescribed antibiotics for acne treatment, and both have a long history of efficacy and safety. 22 While the identification of “the best” oral antibiotic for acne would certainly simplify a treatment regimen, data do not exist that permit such a conclusion to be drawn.

Inconsistencies across trials make it impossible to justly compare products. 3 Methodological variation is commonly seen in randomization, blinding, number of participants, study duration, dosing, and primary/secondary outcome measures. Additionally, it is important to keep in mind that most studies included in this review, by necessity, assessed treatment outcome following monotherapy. However, in clinical practice, oral antibiotics are rarely prescribed as monotherapy. The multifactorial pathophysiology of acne calls for the use of several agents to attack the disease from numerous directions. The combination of oral antibiotics with benzoyl peroxide, combination antibiotics, and topical retinoids is standard of care. 3 Additionally, oral antibiotic monotherapy is discouraged due to the potential development of antibiotic resistance. 2 , 4

When choosing an oral antibiotic for treating acne, there are no data identifying a clearly superior product. Rather, prescriber choice might come down to personal or patient preference, such as delivery vehicle (e.g., capsule vs. tablet), dietary restrictions, gastrointestinal sensitivity, sun exposure, and past experiences with antibiotics. The tetracycline class is probably superior to other antibiotics due to its dual action of antibacterial and anti-inflammatory activities. Additionally, tetracyclines are generally inexpensive and well-tolerated. Between doxycycline, minocycline, and sarecycline, side effect profile might be a determining factor. 61 Doxycycline is generally associated with more upfront, bothersome side effects, like GI upset and photosensitivity. 27 Immediate-release minocycline is associated with a high incidence of vestibular adverse events, but the extended-release formulations and sarecycline have reduced these dramatically and instead show a side effect profile similar to placebo. 35 , 36 The risk of longer-term, more serious side effects (hyperpigmentation, lupus-like drug eruption, and hypersensitivity syndromes), although rare, are more common with minocycline. 26 Azithromycin might be a preferred treatment in patients who are pregnant, although in practice it is rarely utilized. TMP-SMX is an effective treatment for non-responders or in individuals who cannot tolerate tetracycline-class drugs. 54

Regardless of treatment choice, it is critical to keep in mind the CDC’s initiative toward antibiotic stewardship. Antibiotics should always be prescribed responsibly and only when they are necessary to treat disease. 10 Antibiotic monotherapy is discouraged, and antibiotic therapy for long-term management is not recommended for most patients. 2 , 4 Rather, the addition of a topical agent to systemic antibiotic treatment might show a favorable efficacy and safety profile. 62 , 63 Once systemic antibiotic treatment is discontinued, the continued use of topical retinoids or benzoyl peroxide and topical retinoid might be helpful for long-term maintenance therapy. 64 , 65

While azithromycin and TMP-SMX are efficacious, tetracyclines (notably doxycycline, minocycline, and now sarecycline) remain the preferred first-line treatment option for acne due to their established safety and efficacy. No one antibiotic has been shown to be superior to another. Rather, each is associated with different side effects, and treatment choice is based on provider and patient preferences.

ACKNOWLEDGEMENTS

7West Communications provided editorial assistance for the preparation of this manuscript.

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Home » Doxycycline for Acne: How It Works, Benefits, Side Effects & More

Doxycycline for Acne: How It Works, Benefits, Side Effects & More

July 26, 2022

Acne is one of the most widely common skin conditions that affect almost everyone at some point in their lives. It commonly manifests during puberty and appears on the face as the body undergoes hormonal changes.

Many other things can trigger acne, ranging from stress to certain medications and food. Initiating lifestyle changes can help reduce or even resolve acne. However, severe and persistent acne cases often require medical help. Fortunately, various safe and effective treatments, like doxycycline for acne , are available.

Doxycycline is a commonly prescribed antibiotic to treat acne and different skin conditions.

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What does doxycycline treat?

As an antibiotic, doxycycline treats various bacterial infections and diseases. These include:

Skin inflammatory conditions, such as acne and rosacea
Skin infections
Anthrax and tularemia- serious infections that spread as part of a bioterror attack
Malaria prevention
Urinary tract infections
Escherichia coli or E.coli
Pneumonia and other respiratory tract infections

Although doxycycline treats respiratory tract infections, it is not an effective medication for colds, flu, and similar viral diseases. Using doxycycline for such cases may increase the risk of infection and build up antibiotic resistance, lowering the effectiveness of infection treatments.

Doxycycline for Acne – What to Know

Doxycycline is commonly prescribed as an oral medication for moderate to severe bacterial acne. This acne occurs due to excessive bacterial growth in clogged skin pores.

Since it is an oral medication, doxycycline is an ideal treatment option for individuals with acne breakouts on their back or other parts of the body that are difficult to reach and apply with topical acne products.

Doxycycline is also prescribed for mild forms of inflammatory acne that have not responded to other medications. Doxycycline treatments can help calm inflammation, minimize redness, and improve the appearance of pustules and cysts.

How Doxycycline Works for Acne

Doxycycline eliminates bacteria and prevents their continued growth and spread. This holds true regardless of whether the medication is used in treating acne or other bacterial infections and conditions.

Doxycycline kills the Cutibacterium acnes or C. acnes (formerly Propionibacterium acnes) bacteria that proliferate in the skin. This bacteria causes the oil glands to produce more oil, which is one of the primary causes of acne and pimples.

Due to how the medication works, doxycycline exhibits lower effectiveness in treating non-inflammatory acne, such as blackheads and milia.

How Long Does Doxycycline Take to Work for Acne?

Doxycycline is absorbed almost wholly after ingestion. However, it takes some time before users experience its full benefits and effects.

People may start to see signs of improvement beginning at the two-week mark. It is more common, though, for the medication to take up to 12 weeks or three months of regular use before any positive changes are evident.

Doctors generally prescribe doxycycline treatment for three months. The patient may risk developing antibiotic resistance to the drug any longer than that. The doctor may re-evaluate and extend the treatment depending on the severity of the acne and the overall response to the treatment.

Doxycycline Dosage for Acne

The typical doxycycline dosage for acne can start at 40 mg once daily, particularly for delayed-release tablets or capsules. After that, the dosage can be increased up to 100 mg twice daily, depending on how severe the condition is.

Doxycycline is only available with a doctor’s prescription. The prescribed dosage may depend on the brand, the patient’s age, and the acne’s severity. The type of the medication, such as whether the tablet is a delayed-release type, may also affect the prescribed dosage.

Doxycycline treatments are usually short-term to prevent the development of antibiotic resistance. As a result, physicians and dermatologists often prescribe the medication for only three to four months at a time.

How to Use Doxycycline for Acne

Doxycycline is an excellent oral antibiotic treatment for acne and other skin inflammatory conditions. However, it is best used with other treatment options for acne to ensure all factors that may cause or trigger acne breakouts are addressed.

Doctors usually prescribe doxycycline together with other topical acne medications. For example, benzoyl peroxide and topical retinoids are safe with doxycycline and help produce faster, better results.

Warnings and Precautions

As a general precaution, patients should always inform the doctor about allergies and any prescriptions, medications, or supplements they may take. These can help minimize adverse effects and drug interactions.

Doxycycline may decrease the overall effectiveness of hormonal contraceptives. Therefore, women are advised to consult their doctors regarding switching to other forms of birth control.

Taking the medication also increases photosensitivity or sensitivity to the sun. This may cause skin rashes, itching, redness, and severe sunburn. As such, it is often best to limit staying in direct sunlight. In addition, ensure to take necessary precautions, such as sunscreen and protective clothing outdoors.

4 common side effects of taking doxycycline for acne

Common Side Effects of Doxycycline

Like other medicines, doxycycline may cause unwanted side effects . These include:

Upset stomach. It is recommended to take doxycycline after meals. However, eating or drinking dairy products before taking medicine may make it less effective.

Indigestion and esophagus pain. Doxycycline may irritate the esophagus and make it difficult or painful to swallow. It’s best to take tablets and capsules with water and to avoid lying down for an hour or so after ingesting the medication.

Sensitivity to the sun. The medication increases the overall sun sensitivity of the skin. This can be countered by wearing sunscreen daily and reapplying it every two hours outdoors.

Some people also report losing appetite, rashes or hives, and teeth discoloration due to the medication. Teeth color discoloration can be permanent when doxycycline is taken during the tooth development, from the last half of pregnancy up to eight years old.

Doxycycline’s more common side effects do not warrant immediate medical attention. However, check with a healthcare professional in case of multiple adverse or extreme side effects simultaneously is recommended.

Watch out for serious side effects, such as:

High blood pressure, heralded by symptoms like blurry vision and headache
Pancreatitis
Severe skin reactions, like blisters or purple spots
Difficulty breathing or swallowing
Severe or persistent diarrhea

Alternative Treatments for Acne

Many effective natural and alternative treatments reduce inflammation and acne breakouts. These include:

Topical products with at least 5% tea tree oil, such as creams, serums, or cleansers

Creams containing 5% bovine cartilage

Apple cider vinegar and water mixture as a facial toner

Homemade facial mask using honey and cinnamon powder

Drinking green tea regularly or applying cooled brewed tea to the skin

Make sure to do a patch test when trying new acne drugs or alternative homemade treatments. It is also best to consult a medical professional or dermatologist to ensure the treatments will not have any adverse reactions with any medications you may be taking.

Frequently Asked Questions

Yes. Specifically, doxycycline helps in clearing bacterial acne.

Cutibacterium acnes or Propionibacterium acnes is a type of bacteria that lives in the oil glands of our skin. When hormone changes trigger the oil glands to produce more oil, it causes this bacteria to multiply, which causes inflammation and acne.

Doxycycline helps clear acne by killing C. acnes. This reduces and prevents inflammation, one of the primary triggers of acne breakouts.

Taking only doxycycline will not cure acne sufficiently or permanently. Taking doxycycline is meant to help kill off and limit the proliferation of bacteria that causes C. acnes.

Although it can significantly help reduce C. acnes and inflammation, it does not address other causes of acne. Therefore, people suffering from acne need additional treatments to prevent acne breakouts due to other causes or triggers.

Doxycycline is not meant for prolonged intake. It is primarily intended to control bacterial growth and help prevents acne from worsening. People who are only taking doxycycline for acne and no other medications will usually see a return of acne and pimples after stopping the treatment.

This is why doctors often prescribe doxycycline and other acne treatments, such as benzoyl peroxide or retinoid creams. This allows them to address other factors that may trigger acne. As such, people dealing with acne continue to see improvements in their acne condition even after they stop taking doxycycline.

Doxycycline is absorbed almost wholly after ingestion. However, it takes some time before its full benefits are seen and felt.

Some people start to see signs of improvement starting at the two-week mark of taking the antibiotic. But, generally, it can take up to 12 weeks or three months of doxycycline treatment before they experience any positive changes.

In general, doctors typically limit patients taking doxycycline to only three months of treatment. This is primarily done to prevent Propionibacterium acnes or the bacterial acne they cause from becoming resistant to the antibiotic.

Take note that this is only a general guideline. Some doctors may extend the doxycycline treatment duration depending on how the patient reacts.

Some people use doxycycline and tretinoin together. However, doctors generally do not recommend taking doxycycline simultaneously with tretinoin. This is because using these two medications simultaneously may increase the potential risk of pseudotumor cerebri, also known as “false brain tumor” or idiopathic intracranial hypertension.

Although it can significantly help reduce C. acnes and inflammation, it does not address other causes of acne. People suffering from acne will also need other treatments to prevent acne breakouts due to other causes or triggers.

Doxycycline is not meant for prolonged intake. It is primarily meant to control bacterial growth and help prevents acne from worsening. People who are only taking doxycycline for acne and no other medications will usually see a return of acne and pimples after stopping the treatment.

Doctors often prescribe doxycycline and other acne treatments, such as benzoyl peroxide or retinoid creams. This allows them to address other factors that may trigger acne. As such, people dealing with acne still continue to see improvements in their acne condition even after they stop taking doxycycline.

Doxycycline is absorbed almost completely after ingestion. However, it takes some time before its full benefits are seen and felt.

Some people start to see signs of improvement starting at the two-week mark of taking the antibiotic. Generally, it can take up to 12 weeks or three months of doxycycline treatment before they experience any positive changes.

Doctors typically limit patients taking doxycycline to only three months of treatment. This is primarily done to prevent Propionibacterium acnes or the bacterial acne they cause from becoming resistant to the antibiotic.

Some people use doxycycline and tretinoin together. However, doctors generally do not recommend taking doxycycline simultaneously with tretinoin. Using these two medications simultaneously may increase the potential risk of pseudotumor cerebri, also known as “false brain tumor” or idiopathic intracranial hypertension.

The content on Doctor Alexa’s blog is reviewed by Advanced practice registered nurses or pharmacist and is intended for educational purposes only. This information should not be relied upon as professional medical counsel. Be sure to always consult with your physician about the dangers and benefits of any medication, treatment or procedure.

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Doxycycline for Acne Treatment: A Comprehensive Guide

Struggling with acne can be a relentless and disheartening journey. After trying countless creams, gels, and cleansers without success, I finally gained control over my acne by using doxycycline. In this guide, I'll provide you all the essential information on successful use of doxycycline as an effective treatment for your skin condition - benefiting from its powerful antibacterial properties while minimizing any possible side effects.

Introduction to Doxycycline for Acne Treatment

Doxycycline is a powerful antibiotic that works in an innovative way to improve your complexion. This versatile treatment method both works from the inside out and directly targets acne-causing bacteria, reducing inflammation and decreasing breakouts - all without irritating or drying out skin like other topical solutions can do!

How Doxycycline Works for Acne Treatment

Doxycycline targets the underlying cause of acne, P. acnes bacteria, providing a long-term solution to breakouts and inflammation caused by this common skin condition. By reducing their presence on the skin surface, doxycycline works effectively to prevent new blemishes from forming, while helping clear up existing outbreaks.

Doxycycline has the potential to treat beyond just bacteria of acne, as its anti-inflammatory abilities can relieve redness and swelling associated with more severe forms. Through this, it is often used for the treatment of cystic acne.

Doxycycline Hyclate vs. Doxycycline Monohydrate: Which is Better for Acne Treatment?

For those looking to treat their acne, two popular formulations of doxycycline exist: hyclate and monohydrate. While both are effective for treating blemishes, each has its own unique properties worth considering when making a decision on which is the best choice.

Doxycycline hyclate is the commonly-known formulation with a low risk of side effects. However, those seeking greater efficacy may find doxycycline monohydrate worth the additional cost due to its availability in tablet form only.

Your doctor can guide you towards the best doxycycline formulation for your needs, ensuring that all relevant factors are taken into account. They can help find a suitable option, so you feel comfortable and confident in any choice made.

Other Antibiotics Commonly Used for Acne Treatment

While doxycycline is a popular choice for treating acne, it is not the only antibiotic that can be effective. There are several other antibiotics commonly used for acne treatment, including:

Azithromycin
Erythromycin
Minocycline
Tetracycline

Each of these antibiotics works slightly differently, and may be more or less effective for different types of acne. Your doctor can help you determine which antibiotic is best for your individual needs.

How Long Does Doxycycline Take to Work for Acne?

Everyone's body and acne severity are unique, so the time to see improvement on doxycycline for acne treatment can vary. However, by understanding how your system responds to medications and properly managing inflammation in the skin, you may start seeing beneficial results from this medication sooner rather than later.

Consistency is key when it comes to tackling your acne. Although you may not see results overnight, taking doxycycline as prescribed can help yield long-term success in the war against blemishes over several months.

Common Side Effects of Doxycycline for Acne Treatment

Like all medications, doxycycline can cause side effects. Some of the most common side effects of doxycycline for acne treatment include:

Sun sensitivity

While these side effects can be uncomfortable, they are usually mild and go away on their own as your body adjusts to the medication. If you experience severe or persistent side effects, speak with your doctor.

How Long Do Doxycycline Side Effects Last?

Some side effects may be short-lived, while others could take longer to subside. However, in most cases relief should come within a week of taking the medicine.

Severe or long-lasting side effects should never be disregarded; speak to your health practitioner if this is the case. Adjusting dosages and finding alternatives could help relieve these discomforts, so it's critical for your wellbeing that you seek medical attention in such scenarios.

Best Practices for Taking Doxycycline for Acne Treatment

To get the most benefit from doxycycline for acne treatment, it is important to follow some best practices:

Take doxycycline as prescribed by your doctor.
Take doxycycline with a full glass of water to help prevent irritation of the esophagus.
Do not lie down for at least 30 minutes after taking doxycycline to help prevent irritation of the esophagus.
Avoid taking doxycycline with dairy products, antacids, or iron supplements, as these can reduce its effectiveness.
Wear sunscreen and protective clothing while taking doxycycline, as it can increase your sensitivity to the sun.

When to Consider Doxycycline for Acne Treatment

Acne that doesn't respond to traditional treatments, and those plagued by severe, inflammatory cystic acne, can benefit from doxycycline. This medication can significantly improve your skin condition if used correctly.

Acne is a serious skin condition, and it's important to consult with your doctor to decide if doxycycline treatment would be the most effective option for you. Your physician will help determine what course of action best fits your individual needs.

Conclusion: Is Doxycycline a Good Option for Your Acne?

Doxycycline is an effective treatment for acne, targeting the bacteria that cause it and reducing inflammation. With minimal side effects, this medication helps curtail breakouts while minimizing any unpleasantness associated with them.

If you've been fighting acne with no victory in sight, doxycycline could be the key to unlocking clear skin. But before starting on this medication, talk to your doctor first - they'll know if it's right for you and how to take it. Used correctly, this drug has proven effective at removing those stubborn blemishes and restoring healthier-looking facial features!

For those struggling with acne, an effective treatment plan requires consistency and patience. Don't be discouraged if results don't show right away; a little dedication can go a long way towards achieving the clear skin you desire!

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4 Doxycycline Acne Purging Stages (Everything You Need to Know)

by Martin Hansen
August 17, 2023

Acne, an issue that affects many, often requires precise and effective management. One prominent solution in the acne treatment arsenal is doxycycline. This oral antibiotic, part of the tetracycline family, has long been used to treat acne, especially moderate to severe inflammatory acne.

This post will explore the 4 doxycycline acne purging stages, detailing everything you need to know about how doxycycline works, what acne purging is, and how to handle each stage.

Also read: How to choose the best acne treatment

Biggest Take-Aways:

Doxycycline is a widely-used oral antibiotic for managing acne vulgaris, but it has potential side effects and interactions that individuals need to be aware of.
Hormonal imbalances, particularly in teenagers and adults, can lead to severe acne, and doxycycline can effectively treat these conditions, though with consideration.
Alternative methods, like Exposed Skin Care, are available for those concerned about the side effects or interactions likely to be caused by antibiotics like doxycycline.
Exposed Skin Care provides a comprehensive solution for various acne types, offering an effective treatment without antibiotics, and aligns with specific skincare needs without potential side effects.

Teen girl looks at face with mirror after bathing

Stage 1: The Initiation Phase

The initiation phase is where the doxycycline acne purging stage begins. This stage is marked by the introduction of the antibiotic into the system and the initial reaction of the skin.

Understanding Doxycycline

Doxycycline is an antibiotic used to treat bacterial infections, and it's also utilized to manage acne vulgaris. Here's what you need to know:

Acne Medication: As an oral antibiotic, doxycycline treats acne by attacking bacteria on the skin, reducing inflammation.
Dosage of Doxycycline: Usually prescribed in doses like doxycycline 100 mg or 40 mg, depending on the type of acne.
Doxycycline Hyclate: A common form of doxycycline used to treat acne.

Skin Purging

Skin purging refers to the skin's response to an active substance that accelerates skin cell turnover. When you take doxycycline for acne, it can cause skin purging, which means:

Increase in Breakouts: Your acne may worsen initially as dead skin cells are shed.
Reduction in Inflammatory Acne: Over time, inflammatory acne is likely to reduce.

Stage 2: The Purging Process

The purging stage is perhaps the most challenging part of the doxycycline acne purging process. This phase can be characterized by various changes in the skin, leading to improvements.

How Doxycycline Works in Purging

Doxycycline helps in treating acne by targeting specific bacteria associated with acne. Here are the key aspects:

Topical and Oral Treatment: Doxycycline may be combined with topical acne treatments like benzoyl peroxide.
Reduction in Pores: The use of doxycycline reduces pore visibility and inflammation.
Treatment for Different Types of Acne: It can be used to treat acne lesions, cystic acne, and moderate acne.

Stage 3: Stabilization

The stabilization phase is where the effect of doxycycline really begins to show, and improvements in acne become more noticeable.

Improvement in Acne

During this stage, you will notice:

Decrease in Breakouts: Acne isn't as prominent.
Improved Skin Texture: Dead skin cells are replaced, and future acne is prevented.
Less Need for Topical Treatments: Doxycycline alone becomes effective.

Woman with smooth face looking at mirror

Stage 4: Maintenance

The final doxycycline acne purging stage is the maintenance phase, where the skin has adapted to the antibiotic, and acne is under control.

Continuing Treatment

In this phase:

Maintaining Results: Treatment of acne continues with a full glass of water along with doxycycline.
Avoiding Side Effects: Awareness of common side effects of doxycycline helps in management.

How Doxycycline Works for Hormonal Acne

Doxycycline is an oral antibiotic that has been shown to be effective in treating severe acne. Its properties and ways it works for acne include:

Targeting Bacteria: Doxycycline can cause a reduction in acne-causing bacteria on the skin.
Anti-inflammatory Effect: It helps in reducing inflammation often associated with hormonal acne.
Combination Therapy: Doxycycline also works well with other acne medicines like benzoyl peroxide for a comprehensive treatment for acne.

However, it's important to note that doxycycline might interact with other medications, making doxycycline less effective. Therefore, individuals prescribed doxycycline must follow guidelines closely to achieve optimal results.

Person taking Doxycycline from medicine bottle

Considerations When Using Doxycycline for Acne

When you use doxycycline for acne, there are several considerations to keep in mind:

Understanding Side Effects: Common doxycycline side effects include phototoxicity of doxycycline. Side effects you might experience should be discussed with healthcare providers.
Minocycline Comparison: Both doxycycline and minocycline are used to treat acne. Doxycycline is a tetracycline antibiotic and is often preferred due to fewer side effects.
Effect on Acne Scars: Doxycycline also improves acne scars and overall skin texture.
Discontinuation: If purging occurs or serious side effects are experienced, don’t abruptly stop taking doxycycline without professional guidance. Sudden cessation can cause the skin to react negatively.

Doxycycline is used not only for treating bacterial infections but also as an effective solution for hormonal acne. The likely beneficial outcomes make it a go-to option, but users should know how doxycycline works for acne and be mindful of potential side effects.

Managing Acne with Exposed Skin Care: An Alternative to Antibiotics

While antibiotics like doxycycline are commonly prescribed for managing acne vulgaris, they may not suit everyone. Some individuals may be concerned about its side effects. Exposed Skin Care 's unique blend of scientific ingredients and natural extracts offers a robust approach to treating acne.

Here's what you need to know about the benefits:

Effective Treatment without Antibiotics: If you're not keen on taking an antibiotic for acne like doxycycline, Exposed Skin Care provides a viable alternative.
Complete Care for Various Acne Types: Whether hormonal imbalances cause acne or other factors, Exposed's range of products addresses various acne issues.
Avoid Potential Interactions: Unlike some medications that might interact with doxycycline, Exposed Skin Care is designed to work smoothly with your skincare routine.
Less Need for Prescription Medications: With Exposed Skin Care, there is less need to take doxycycline or other prescription antibiotics, reducing concerns about potential side effects.

Choosing Exposed Skin Care for acne management offers a comprehensive and non-invasive approach that can be tailored to your specific needs. Its effective formulas provide a promising alternative to traditional antibiotic treatments and align with your skincare goals.

In the journey to understand the complexities of acne management, understanding the various ways to treat acne is vital. For many, this journey involves learning what they need to know about doxycycline, a common antibiotic used to treat severe acne.

Doxycycline's role, its interaction with hormonal acne, its effectiveness, and the potential side effects it's likely to cause have been explored thoroughly. The management of acne vulgaris isn't limited to antibiotics alone.

Alternative methods are available, including innovative products such as Exposed Skin Care, offering a complete care system that targets various acne types without prescription medications. It represents a harmonious blend of science and nature to tackle acne without causing additional complications.

As the understanding of acne continues to evolve, so does the range of treatments. Individuals concerned about the side effects likely to cause discomfort with antibiotics can find comfort in alternative products that align with their specific needs and skincare goals.

Recognizing the unique needs of one's skin, understanding the treatment's intricacies, and choosing a path that resonates with personal preferences ensures a more satisfying journey towards healthier skin.

Q: Can Doxycycline Cause Side Effects?

Yes, common side effects of doxycycline can include phototoxicity. Make sure to follow the prescribed dosage of doxycycline to minimize these risks.

Q: How Long Should You Take Doxycycline for Acne?

Doxycycline is usually taken for a prescribed period. Stopping abruptly or taking doxycycline for longer without supervision may cause problems.

Q: Can Doxycycline Treat Other Bacterial Infections?

Yes, doxycycline is an antibiotic used to treat bacterial infections and is also used to treat various types of acne.

Q: What Should You Know about Generic Doxycycline?

Generic doxycycline works similarly to brand-name versions, and it's prescribed to treat acne as well.

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Doxycycline for Acne: A Comprehensive Guide

Doctor's Guide on Using Doxycycline for Acne

Doxycycline is an antibiotic that is commonly used to treat acne. It works by preventing bacterial growth and multiplication and is a member of the tetracycline antibiotic family. In cases of moderate to severe acne, doxycycline may be an effective treatment. It has anti-inflammatory properties and stops Propionibacterium acnes (P. acnes) from growing. However, it is crucial to follow the medication's instructions precisely and to be aware of any possible side effects and precautions.

Introduction

Acne treatments can be time- and labour-intensive. If you've seen a dermatologist (skin specialist), you may have heard of doxycycline or even had it prescribed as part of a skincare routine. Let's discuss what you need to know about doxycycline, which is a well-known acne medication. Doxycycline is an antibiotic, which means that it kills bacteria. It belongs to a group of antibiotics called tetracyclines. The other two medications in this group are tetracycline and minocycline. Although we don't know which antibiotics are more potent than others, your doctor will work with you to find the most effective course of action. Minocycline and doxycycline are more frequently prescribed than tetracycline due to their fewer side effects (such as upset stomach) and less frequent dosing requirements.

Understanding Acne

Acne is a skin condition that affects millions of people around the world. It happens when hair follicles become clogged with oil and dead skin cells, causing pimples, blackheads, and whiteheads to form. Acne is most frequently linked to adolescence, but it can happen at any age and has a big impact on a person's self-esteem and quality of life. Numerous factors, such as genetics, hormonal changes, and specific medications, can contribute to acne. Hormonal changes during puberty, pregnancy, and menstruation can cause an increase in sebum production, an oily substance that helps lubricate the skin. When sebum combines with dead skin cells and bacteria, it can clog pores and cause acne. The following additional elements can also affect the occurrence of acne, in addition to hormonal changes:

Poor skincare : Skipping a face wash can cause an accumulation of oil and dead skin cells, which raises the possibility of developing acne.

Diet : Consuming a diet that is high in sugar and refined carbohydrates may help acne develop.

Stress : Excessive amounts of stress can cause hormonal imbalances and inflammation, both of which can exacerbate acne.

Medication : Corticosteroids are one type of medication that can make acne more likely.

What is Doxycycline?

Doxycycline is a broad-spectrum antibiotic in the tetracycline class of antibiotics. It's used to treat bacterial infections like respiratory infections, urinary tract infections, and sexually transmitted infections. Doxycycline stops bacteria from assembling necessary proteins, which restricts their capacity to expand and multiply. Doxycycline, which has antimicrobial and anti-inflammatory properties, is also used to treat acne. It works by inhibiting the growth of Propionibacterium acnes (P. acnes), one of the main causes of acne. Furthermore, it has anti-inflammatory properties that can aid in the reduction of acne-related inflammation. Doxycycline is usually taken orally as tablets or capsules. On a daily basis, it is typically taken once or twice, with or without food, as prescribed by a doctor. The dosage and length of treatment may vary depending on the kind and severity of the infection being treated. Doxycycline, like all antibiotics, can have side effects. Common doxycycline side effects include nausea, diarrhea, stomach upset, and photosensitivity. Severe skin reactions, liver damage, and allergic reactions are all possible side effects. If any severe side effects occur, contact a healthcare provider immediately.

How Doxycycline Works for Acne?

Doxycycline treats acne by focusing on its two key components: bacterial development and inflammation. Propionibacterium acnes (P. acnes) is a type of bacteria that lives on the skin's surface and inside hair follicles. Inflammation and the growth of pimples, whiteheads, and blackheads happen as a result of P. acnes' preference for the oily conditions of hair follicles. As a broad-spectrum antibiotic, doxycycline works by halting bacterial growth and reproduction, including P. acnes. By lowering the number of bacteria on the skin, doxycycline reduces inflammation and stops the development of new pimples. In addition to having antimicrobial properties, doxycycline also has anti-inflammatory properties that make it useful for treating acne. Acne is an inflammatory condition, and P. acnes can cause an immune reaction that leads to inflammation and the development of pimples. By reducing inflammation, doxycycline can aid in reducing the redness, swelling, and discomfort brought on by acne.

Using Doxycycline for Acne Treatment

You must carefully follow any instructions given by your doctor if they have prescribed doxycycline for the treatment of your acne. When taking doxycycline for acne treatment, it is critical to carefully follow your healthcare provider's instructions. Even if your acne has improved, do not stop taking the medication without first consulting your doctor . Stopping the medication too soon can result in a relapse of acne.

Types of Acne Treated with Doxycycline

When other therapies, such as topical medications, have failed to control the condition, doxycycline is frequently used to treat moderate to severe acne. Doxycycline can be used to treat the following types of acne:

Inflammatory acne : This type of acne is characterized by pimples that are red, swollen, painful, and sometimes tender to the touch. P. acnes bacteria frequently contribute to this type of acne by inducing an inflammatory immune response. Doxycycline can aid in reducing P. acnes growth and the resulting inflammation, which will decrease inflammatory acne.

Papules and pustules : These small, raised bumps on the skin are frequently filled with pus. These particular acne lesions are brought on by an accumulation of dead skin cells, bacteria, and oil in the hair follicles. Doxycycline can help reduce the bacterial growth and inflammation associated with papules and pustules, leading to a reduction in their size and number.

Nodular and cystic acne : Nodular and cystic acne are severe forms of acne that are characterized by large, painful, and deep-rooted pimples. These types of acne lesions are often resistant to other treatments, such as topical medications. The severity of nodular and cystic acne can be lessened by using doxycycline to help reduce the inflammation and bacterial growth associated with these conditions.

Acne rosacea : Acne rosacea is a long-term inflammatory skin condition that causes facial flushing, redness, and small bumps. As it can aid in reducing inflammation and bacterial growth connected to this condition, doxycycline is frequently prescribed in low doses for the treatment of acne rosacea.

Dosage and Prescription

The amount of doxycycline prescribed and the severity of the acne will depend on these factors as well as the patient's medical history. Here are some general recommendations for doxycycline dosage and prescription for acne:

Dosage : Doxycycline is usually taken once or twice a day, depending on the severity of the acne and the dosage prescribed by the doctor. The typical daily dose ranges from 50mg to 100mg.

Timing : Doxycycline can be taken with or without food, but it is critical to take it at the same time each day to ensure consistent blood levels.

Duration of treatment : The length of treatment will be determined by the severity of the acne and the effectiveness of the medication. Doxycycline treatment usually lasts several weeks or months.

Precautions : Doxycycline can make you more sensitive to sunlight, so wear sunscreen and avoid prolonged sun exposure. It is also critical to avoid taking doxycycline with milk or other dairy products, as these can interfere with the medication's absorption.

Follow-up : While taking doxycycline for acne treatment, it is critical to see your doctor on a regular basis. This is done to monitor the medication's effectiveness and to keep an eye out for any potential side effects.

Potential Side Effects

Like all medications, doxycycline can cause potential side effects. The following are a few of the most typical negative effects of doxycycline:

Gastrointestinal upset : Doxycycline can cause stomach upset, such as nausea, vomiting, and diarrhea.

Photosensitivity : Doxycycline may increase a person's skin's sensitivity to sunlight, which increases their risk of getting sunburned and causing skin damage. When taking doxycycline, it's critical to use sunscreen and stay out of the sun for as long as possible.

Yeast infections of the vagina : Doxycycline can upset the normal bacterial balance in the vagina, which can result in a yeast infection.

Enamel hypoplasia and tooth discoloration : If Doxycycline is taken by children under the age of 8, it can result in underdeveloped teeth and enamel hypoplasia (permanent tooth discoloration).

Rare but severe side effects : Doxycycline can occasionally result in severe side effects like liver damage, severe allergic reactions, and elevated intracranial pressure.

Alternatives to Doxycycline for Acne

While doxycycline is an effective treatment for acne, there are also several alternatives that may be considered. Here are some common alternatives to doxycycline for acne:

Minocycline : Minocycline is a different tetracycline antibiotic that is frequently used to . It functions similarly to doxycycline by reducing inflammation and eradicating acne-causing bacteria.

Tetracycline : Tetracycline is an antibacterial that was first used to treat acne. The availability of more recent antibiotics like doxycycline and minocycline, however, has made them less popularly used today.

Azithromycin : Azithromycin is a macrolide antibiotic that can also be used to treat acne. It works by reducing inflammation and killing bacteria that cause acne.

Topical treatments : There are a number of topical treatments for acne in addition to oral antibiotics. These include topical antibiotics like clindamycin, retinoids, and benzoyl peroxide.

Hormonal therapies : For women, hormonal therapies like spironolactone and birth control pills may be successful in treating acne.

Over-the-Counter Products for Acne

There are several over-the-counter (OTC) products available that can be used to treat mild to moderate acne. Here are some common OTC products for acne:

Benzoyl peroxide : This topical acne treatment works by eradicating acne-causing bacteria and reducing inflammation. It is offered in gels, creams, and lotions with strengths ranging from 2.5% to 10%.

Salicylic acid : Salicylic acid , a beta-hydroxy acid, exfoliates the skin and clears clogged pores. It can be found in cleansers, toners, and spot treatments in strengths ranging from 0.5% to 2%.

Retinoids : Retinoids, which are vitamin A derivatives, increase cell turnover and prevent the accumulation of oil and dead skin cells in the pores by accelerating cell turnover. They are offered in creams, gels, and lotions with strengths ranging from 0.025% to 0.1%.

Sulfur : Sulfur is a mineral that occurs naturally and has the ability to unclog pores and reduce inflammation. It can be found in cleansers, masks, and spot treatments in strengths ranging from 3% to 10%.

Tea tree oil : Tea tree oil functions as a natural antiseptic by eradicating acne-causing bacteria. It comes in creams, gels, and spot treatments with concentrations ranging from 5% to 10%.

Prescription Medications for Acne

Prescription medications may be necessary for moderate to severe acne or acne that has not responded to OTC treatments. Here are some common prescription medications for acne:

Topical antibiotics : Topical antibiotics like erythromycin and clindamycin work by eradicating the acne-causing bacteria from the skin. They come in creams, gels, and lotions, and are typically combined with other topically applied or orally taken medications.

Topical retinoids : Topical retinoids like tretinoin, adapalene, and tazarotene work by accelerating cell turnover and preventing the buildup of dead skin cells and oil in the pores. They come in creams, gels, and lotions and can irritate and dry out the skin.

Oral antibiotics : Antibiotics taken orally, such as doxycycline, minocycline, and tetracycline, work by thinning the inflammation and eradicating the acne-causing bacteria. They are frequently prescribed in conjunction with topical medications and are typically used for moderate to severe acne.

Hormonal treatments: Hormonal treatments like birth control pills and spironolactone may be effective in treating acne in women. They work by regulating hormones that can contribute to acne.

Isotretinoin: Isotretinoin, also known by the brand name Accutane, is a potent oral medication used to treat severe acne that has not responded to other therapies. It works by reducing the size of the sebaceous glands and reducing the production of sebum. Isotretinoin has potentially serious side effects and requires close monitoring by a healthcare provider.

Acne Prevention and Management Tips

In addition to using medications to treat acne , there are several steps you can take to prevent and manage acne:

Use a gentle cleanser to wash your face twice daily to get rid of makeup, oil, and dirt.

Squeezing or picking at acne increases the risk of scarring and the spread of bacteria to other areas of the face.

Scrubs, astringents, and harsh soaps can irritate the skin and exacerbate acne. Avoid harsh, comedogenic products.

To keep your skin moisturized and to avoid dryness, use a non-comedogenic moisturizer.

To protect your skin from the damaging rays of the sun, use a broad-spectrum sunscreen with an SPF of 30 or higher.

Stress can contribute to acne by increasing inflammation and hormone production. Try stress-reduction exercises like yoga, meditation, or deep breathing.

A healthy diet can help to promote overall skin health even though there is no direct connection between diet and acne. Consume a diet that is well-balanced and full of fresh produce, whole grains, and lean protein.

Regular exercise can lower stress and enhance skin health in general.

Talking to Your Doctor About Doxycycline for Acne

If you are considering using doxycycline to treat your acne, it is important to discuss this with your doctor. Your doctor can provide you with guidance and advice on whether doxycycline is a suitable option for you and how to use it safely and effectively. You can discuss the following with your doctor or online dermatologist : your medical history; the severity of your acne; the dosage and duration of the medication; any side effects; and future appointments. It is important to follow your doctor's instructions carefully when using doxycycline to treat acne.

Medical Consultation and Evaluation

Your overall health and well-being are ensured through medical consultation and evaluation, which are crucial steps. You can anticipate the following during medical consultation and evaluation:

Medical history : Your doctor will inquire about your past medical history, including any illnesses or injuries, any prescription drugs or dietary supplements you may be taking, and any family medical history.

Physical examination : To look for any symptoms of a disease or illness, your healthcare provider may conduct a physical examination. This might entail taking your temperature, heart rate, blood pressure, and other vital signs.

Laboratory tests : In order to rule out particular medical conditions, your doctor might order certain laboratory tests. These could involve imaging tests like X-rays or CT scans, as well as blood and urine tests.

Diagnosis and treatment plan : Based on your medical history, physical examination, and test results, your healthcare provider will make a diagnosis and develop a treatment plan. This may include medications, lifestyle changes, or further testing and evaluation.

Follow-up appointments : In order to track your development and make any necessary modifications to your treatment plan, your healthcare provider may schedule follow-up appointments.

Safety Considerations and Precautions

To protect yourself from potential harm or injury, it is crucial to take safety precautions and considerations. Following are some general safety suggestions and measures to remember:

Follow instructions : Always follow instructions carefully for any medication or treatment you are using. This includes adhering to any additional instructions provided by your healthcare provider, using medical equipment correctly, and taking medications as directed.

Keep track of your medications : Keep track of all medications you are taking, including over-the-counter medications and supplements. Because some medications may interact with one another, be sure to tell your healthcare provider about all the medications you are taking.

Practice safe sex : If you engage in sexual activity, engage in safe sex to lower your risk of STIs and unintended pregnancies. When necessary, use condoms and other types of protection.

Wear protective gear : If you are participating in sports or other activities that could result in injury, wear appropriate protective gear. This may include helmets, knee pads, or other protective equipment.

Maintain proper hygiene : Maintain proper hygiene to stop the spread of infections and germs. This entails frequently washing your hands, covering your mouth and nose when you cough or sneeze, and keeping a distance from people who are ill.

Get vaccinated : Maintain current vaccination records to safeguard yourself against diseases that can be prevented by vaccination.

When necessary, seek medical attention : If you experience any strange symptoms or side effects from medication or treatment, do not wait to see a doctor.

Follow-Up Care and Monitoring

Making sure you receive the right medical attention and support for your condition requires monitoring and follow-up care. Here are some general guidelines for follow-up care and monitoring:

Follow-up appointments : In order to track your development and make any necessary modifications to your treatment plan, your healthcare provider may schedule follow-up appointments. It is crucial that you keep these appointments and let your healthcare provider know if your symptoms or health situation change.

Regular check-ups : Your healthcare provider may advise regular check-ups to monitor your general health and well-being, depending on your health condition. This could involve standard blood tests, imaging analyses, or other diagnostic exams.

Medication management : If you need to take medication for your health condition, your doctor may keep track of your usage and change your prescription or dosage as necessary.

Changes in lifestyle : Your healthcare provider may suggest changes in lifestyle to help manage your symptoms and enhance your general health, depending on your health condition. This might entail modifying your eating habits, exercise routine, or other practices.

Support resources : To help you manage your health condition and enhance your quality of life, your healthcare provider may suggest support resources like support groups, counselling, or other services.

Conclusion

You can significantly enhance your general health and well-being by seeking medical advice and evaluation. During the consultation and evaluation process, your healthcare provider will take into account your medical history, carry out a physical examination, request any necessary laboratory tests, make a diagnosis, and create a treatment plan specific to your needs. To ensure your safety, adhere to instructions, monitor your medications, practice safe sex and good hygiene, wear appropriate protective gear, get recommended vaccinations on time, and seek medical attention when necessary. You can manage your health and enhance your quality of life by keeping in touch with your healthcare provider for routine checkups, medication management, and lifestyle changes. Remember to be open and honest with your healthcare provider about any worries or questions you may have in order to receive the best medical care and support.

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Doxycycline for Acne User Reviews (Page 3)

Brand names: Vibramycin, Monodox, Oracea, Adoxa, Doryx, Doxy 100, Acticlate, Doryx MPC, Avidoxy, Uracil, Mondoxyne NL, Okebo, Doxy-D, Oraxyl, Doxy-Caps, Alodox, Morgidox, Adoxa Pak, Adoxa TT, Adoxa CK, Targadox LymePak Doxy 200 …show all brand names

Doxycycline has an average rating of 6.8 out of 10 from a total of 714 reviews for the treatment of Acne. 53% of reviewers reported a positive experience, while 21% reported a negative experience.

Reviews for Doxycycline

Top reviews
Most recent
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High rating
Time on medication
June 1, 2014

"I had mild acne for almost 2 years and kept it at bay using over the counter treatments such as face washes and proactive (which didn't work at all). As I approached the 9th grade my doctor put me on doxycycline to prevent scarring. Even after the first week I saw immediate results! It was truly amazing after 6 weeks. I sometimes have bad stomach pain and peeling skin but it's really a small price to pay for good skin. Even though I still have mild breakouts and small larger pimples I have another month to go on my prescription. HIGHLY RECOMMEND, IT KEPT ME OFF ACCUTANE."

November 20, 2014

Monodox (doxycycline) "Low self esteem, not wanting to leave the house, not being able to stay in a relationship because I was so self conscious and miserable, always walking with my head down, couldn't look people in the face, couldn't walk out the house without makeup (although it didn't cover the bumps). I cried almost everyday and hated my life. It all changed in 5 months. I've never seen my face so clear. I'm finally getting my confidence back. Yes it did take some time for the results to fully kick in, but it did work for me and I'm so happy I finally went to the dermatologist after trying a million and one products that never worked; changed my entire diet and drank water and it never work. But Monodox along with Ziana gel definitely changed my life."

May 28, 2014

"I am a 22 year old female and I have suffered from acne on my face, back and chest since I was 15. My face is constantly broken out in huge, painful, red pimples and little bumps. I finally went to a dermatologist and she put me on 100 mg of doxycycline twice a day. I've been taking it for 18 days and my face is already clearing up quite a bit. And I usually can feel new pimples forming under the skin, I haven't felt one since. The directions say to take before eating or 2 hours after eating, but that makes me nauseous. I usually eat and then wait 30 minutes or so. Even with some of the medicine absorbing into the food, I'm still getting results. I highly reccommend this!"

Frequently asked questions

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November 19, 2014

"Generally my acne went away with use of clindamycin cream for a 7 month period. But I got two giant pustules and I was prescribed doxycycline 100mg once a day to treat these issues. The third week my acne got awful but by week 4 it cleared up. I still get zits but no major acne. Overall its been good but I have only been on it a month so I think by month 2 or 3 it will be gone. Stick with it and don't give up."

Taken for 1 to 6 months
October 20, 2013

"So I've just turned 33, I have been battling with acne since puberty, I have tried ever medication topical and oral over the years and I can safely say this stuff actually works, and I'm wondering why the doctor has only prescribed this to me six weeks ago. It is for me a life saver, Or should I say a self esteem saver. When we have clear skin we are confident. I hate wearing caked on makeup at my age and thanks to doxylin a little foundation is all I need now till my scars completely disappear , My skin has changed so much in six weeks, no more breakouts , Well one pimple at period time is not bad at all. I'm so grateful to have found this medication and just in time for Australian summer. I highly recommend it to anyone :)"

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February 25, 2014

Monodox (doxycycline) "I am 25 years old and I have always have had acne. I am one of the people that have tried everything under the sun; proactive, herbal, expensive top of the line products and acupuncture until I decided to speak to my wonderful dermatologist. He has prescribed me 100 Monodox twice a day along with Epiduo and it has worked wonders, no side effects. I've been on this routine for about two and a half months. My skin has NEVER been clear until now. It has been since lately that the Monodox has caused my to be nauseous when I take it in the morning. Since I am not a big breakfast person I found that I must take it with a GOOD meal and the nausea has not come back. "

September 10, 2017

"I was on doxyclyine for about 5 months. Before I started it I had mild acne and just little breakouts on my forehead every once in a while. The first month I was on it, I saw little to no change, but once I got to month 2 my face was almost completely clear. I was also using a topical cream alongside the pill. By month 5, my skin was still clear, but one night when I took the pill I didn't take it with enough water and it didn't go all the way down my throat without me realizing it. I woke up the next morning with crazy chest pain and went to the doctor to find out I got an ulcer in my esophagus from the pill! The pain in my chest lasted about three weeks and it was terrible. Moral of the story, drink lots of water when taking this drug and eat afterwards so the food pushes it all the way down and definitely don't lay down after taking it!!"

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July 6, 2013

Doryx (doxycycline) "I've been struggling with mild acne on my face and severe acne on my shoulders (mostly sports related) for the past 2 years or so, and absolutely NOTHING worked. However, I've been taking Doryx for a week now and my face is almost completely clear, and my shoulders are clearing up FAST. however, I did experience a lot of drying out on my face, as well as (oddly enough) a decreased sex drive. I HIGHLY recommend refraining from alcohol while on this medicine, as it will only worsen the drying of your face. Stick with it. Remember, your face will get worse before it gets better."

May 22, 2014

Monodox (doxycycline) "I have had bad acne since the 4th grade. During my senior year in high school, I was put on Accutane which worked for the duration of time that I was on it (moderately, mild breakouts but the redness went away, a huge step up from my ridiculous acne!) but returned in moderation when I went to college in the fall. I waited until the spring to visit my dermatologist and she put me on two facial creams and Monodox. I tried the facial creams alone, didn't work. Then tried Monodox and within a week, I saw a huge difference. Not only did my acne almost disappear, but my breakouts were 1-2 mild, small pimples that went away leaving no scars in 2 days. I have been on it about 3 months and I couldn't be happier. My face is clear! Highly recommend."

January 30, 2014

Doxy 100 (doxycycline) "I was a 48 y/o female with nodular acne. My pimples were painful, humiliatuing, embarrassing and just plain ugly. I had used every over the counter treatment there was. Once I was diagnosed with nodular acne (severe acne) my dermatologist prescribed Doxy 150mg. By using coupons, It is affordable. I am 52 now and I continue to use Doxy 50 a day at this time. My thought is A CLEAR FACE IS PRICELESS. No more pockets of puss or inflammation on my face."

September 28, 2014

"I'm 27 and I just started taking doxycycline 2x a day 100mg. I saw my skin clearing up or at least no new pimples since day 1! I also use tretinoin cream at night and benzaclin/clindamycin in the morning. I had an upset stomach so far only for one day but the past two days I've been dealing with a bad headache. I'm hoping it'll go away soon. Other than that, this medicine works great on me!"

May 15, 2019

"I LOVE doxycycline! My dermatologist first put me on this when I came to her complaining of my acne. It was horrible during my early teen years so she put me on this. For acne, doxycycline is usually done as only a brief treatment (3-6 months) so it isn't exactly a long-term solution to acne, but it most likely will clear it up for you. I've been on doxycycline multiple times (sometimes my derm suggests I start it up again if my skin flares up after a 2 year break) and it's a tried-and-true drug that always works for me. It makes my skin clear, perfect, smooth, and glowing! No complaints! It has no hormones so it most likely will work for anyone. Just a note though: it takes a while to kick in. it might seem frustrating if it doesn't work after the first few weeks, but just wait it out--mine has taken a month or two to really start working before. But once it does, the results are fantastic."

March 10, 2012

Doryx (doxycycline) "I have had problems with acne all my life. I tried everything from creams, gels, pills and even Accutane. Accutane was extremely harsh and my acne was back within 3 months. I finally was prescribed Doryx along with Acanya in the morning and Epiduo at night. Please be patient as this will make you break out really bad at first but I promise you after 2 months you will see the results. What's great too is you can adjust the dosage once your face clears up so you don't have to take 150mg all the time. My face is all cleared up now and I only take it the week of my period to prevent breakouts."

August 11, 2013

"Doxycycline cleared my skin up after 6 weeks. It's been such a relief to be completely clear for almost 3 months. This is the second time I've used doxycycline and I think it actually worked even better this time around. It finally gave some of my scars a chance to heal and lighten because I wasn't continuously breaking out on top of them. Now, let's see how long my skin will stay like this (fingers crossed). If other people out there are like me and have lived for years just putting up with the breakouts, something like this is worth trying."

December 10, 2014

"Everytime winter comes around I start to break out really bad. Everybody used to tell me where does this acne come from since I don't get it all year but the winter. My teacher recommended it for me since her daughter used it. I immediately went to the dermatologist and told him I need to take doxycycline. I started taking it and haven't broke out since! This is great!"

December 9, 2008

Doxy 100 (doxycycline) "This medicine is great. I have been using it for 2 months and my face is pretty much cleared. I don't have to worry about having extremely oily skin anymore either. I have experienced the nausea and vomited once, but that can be avoided if you take it immediately after a meal."

July 29, 2009

Doryx (doxycycline) "This doesn't allow me to write very much so I can't share my whole story. I hate taking prescription drugs, but I gave Doryx a chance and it's been a God send. I developed acne in my late 20's, after being acne free since puberty. The cyst like acne would hurt badly and leave terrible marks. With Doryx, every zit on my problem areas were completely gone within 4 days and the red marks from past zits have already faded. I was concerned of side effects and I have had none whatsoever. I am supposed to take it everyday, but I only take it Monday-Friday. I once went 5 days without taking it and got a zit, but getting back on the pills cleared it right up. I pay $25 for a months supply, worth every penny."

September 14, 2010

Doryx (doxycycline) "When I first started taking this medication my acne did get worse. However I stuck with it for four months and then my acne COMPLETELY cleared up. I had it bad for the first month. I stopped taking it because my skin was clear. That was a huge mistake. My acne came back in like less then a month and worse than before. I think I went off it too quickly. I am about to go back on it and stay on it until my dermatologist tells me so otherwise this time."

October 15, 2018

"it’s been two months since I started using doxycycline. Guys, oh boy, it TRULY gets worse before it gets better. It took so long for me to see any improvement. Now a few parts of my face are pretty clear, but I've still got a ways to go. I think doxycycline is worth a try, but know what you’re getting into. It won’t get better in a week like I thought it would, it’s a long process."

November 10, 2013

"Got my confidence back. Doxycycline really worked for me. After a long time suffering from all kind of acne from normal pimple to cyst, and huge black and white heads. I am 35 and had tried all type of creams and also pill like Accutane. Nothing worked until I tried Doxycycline. Since the first week taking the pill, I saw my skin improving and my family and friends noticed the skin was looking better. Its been 5 weeks of taking the pills, no more pimples and even the scars are disappearing. I thanks Doxycycline. Only one side effect which is dry throat and feeling more thirsty than usual. I recommend."

Taken for 2 to 5 years
August 25, 2014

"In 6th grade, I had horrible acne. I went to the dermatologist and he prescribed some kind of face wash. I don't Remember what it was, but it stunk and it was very strong. It helped combined with Epiduo, but it peeled my skin off. My acne cleared up very well AFTER stopping it, but in my freshman year in high school, I broke out HORRIBLY.. worse than ever. I went to my family doctor and he sent me back to the dermatologist and the dermatologist said I had a very bad case of cystic acne. My doctor prescribed Doxycycline and within about 2 weeks, my skin showed tremendous improvement. By a month, my skin was so smooth. I tried everything and nothing worked. I'm a junior in high school now and I'm still on it and very happy. "

April 13, 2014

Doxy 100 (doxycycline) "My doctor prescribed Doxy for and put me on 100mg twice a day for 4 months. So far its 2 months and already there is very big improvement in that am confident with my face and every one is commenting on how flawless my skin is. "

June 25, 2016

"Ive been fighting with "acne" since my mod 20s im now 35. I was also a picker. I have anxiety so it became a way to relieve my anxiety its called dermatelomania (not sure of the spelling) anyway I regret not seeing a dermatologist yrs ago because If I dont have pimples I dont pick which means no scarring. I was afraid to try it at first because of some of the reviews saying it got worse before it got better.Not for me ive been on it for almost 3 weeks and I seen a differwnce in the first 2 days. Bow 3 weeks later my skin is bump free. I dont even know how to explain the relief I have and stress that has been lifted off my shoulders. Everyday was a battle for years and I think I tried every product out there through the yrs. Anyway goodluck"

August 16, 2014

"Well I've been on doxycycline for a month and I'm pretty sure it's 100 mg. I've seen no improvement to my face and it has actually made my face worse. I'm starting to wash my face more to see if that will help but my overall experience has so far been terrible."

September 22, 2020

"My dermatologist prescribed me 3 months of doxy to treat acne on my back, in conjunction with a benzoyl peroxide wash every other day... I have been on it for 3 weeks at this point. I have been fine until recently, I have vaginal dryness, which is absolutely zero amounts of fun. And yesterday, even with eating and drinking water it made me nauseous for probably 4 hours. My back seems to be clearing up but I do have scars/discoloration that she said would take longer to fade. 3 months seems like a long time to deal with the lady side effects of this. I will try to remember to come back for an update."

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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Leakproof Travel Bottles, Plug-in Wall Sconces, and Other Recent Strategist Finds

An all-over-the-place assortment of stood-behind products culled from this very website that appears in the most recent April issue of New York Magazine.

Best in Class

Travel bottles that won’t leak.

Teapile’s Travel-Bottle Set looks exactly like the dozens of other options that pop up when you type toiletry bottles into Amazon. But the frequent fliers whom writer Katherine Gillespie interviewed say this 17-piece collection is in a class of its own. It comes with a mix of secure containers, tiny funnels for easy transfers, and a clear carrying case. Writer Rachael Griffiths uses the three-ounce silicone bottles for shampoo and conditioner and the two-ouncers for facial cleanser and moisturizer. The plastic tubs are handy for eye cream , and the 20-ml. pump-top bottles hold her setting spray. And most important, no matter the container, the caps screw on tight: Griffiths has taken the set on 11 flights and has never had a spill.

Celebrity Shopping

Waxahatchee’s lip oil.

“It comes in just a few shades, and it’s really good for everyday wear. I have the red and the pink; they’re subtle and moisturize your lips. I’m not a strong-lip-color- in-the-light-of-day kind of girl.”

Simu Liu’s Sneakers

“I love finding off-the-beaten-path sneakers. I first got introduced to Axel Arigato through my stylist; these are an easy pair that’s versatile and fun. I was really taken by the design and the lines and just the vibe of the shoes. They can go into a street look or something that’s a little more refined.”

Jena Malone’s Emergency Kit

“I can’t not stop if someone needs help, so I’m studying to be an EMT. I learned that every person should have a trauma kit to stop bleeding if you’re in a car accident or if someone needs help before first responders get there. This one has a triangle bandage, which is the best and easiest thing to wrap around wounds.”

This Thing’s Incredible

I wore this cardigan so much i bought two more.

I recently became aware that, for the most part, I am my own boss . And my employee (me) was showing up to work wearing a depressing combination of whatever was around. I needed something I could wear as a Pavlovian signal it was time to work. Then it arrived in my mailbox: the Cardigan from Cou Cou Intimates. I’ve worn it every day since I got it and have bought two more. It’s lightweight and roomy enough to put a shirt under but tight enough to wear by itself. It’s serious without being boring. On its own, there’s the sheerest hint of nipple (very important). I’ll wear it with a tank and a small black skirt or alone, no shirt, with jeans. It’s flung over the edge of my bed when I sleep and on my body when I wake. I’m wearing the Cardigan as I write this, and I’m sure I’ll be wearing it when you read it. — Nicolaia Rips

Best of Brand

The strategist guide to shopping at quince.

Quince carries everything from activewear to jewelry to luggage, and at the Strategist, we’ve tested quite a lot of it. Here, just a few of the products our writers and editors recommend.

Quince Classic Organic Percale Sheet Set

Quince earned our “Best in Class” crown for its cooling percale sheets . Writer Lauren Ro says the sheets are “the crispest and most lightweight of all the bedding I have tried over the years.”

Quince Mongolian Cashmere Crewneck Sweater

This crewneck is our favorite accessible cashmere sweater for both men and women . Writer Arielle Avila describes it as “supersoft with a slight slickness to it.”

Quince’s silk pillowcase recently won “best overall” in its category. “It’s less than half the price of the Slip,” says writer Tembe Denton-Hurst , “but just as luxurious and gave me near-identical results.”

Quince Washable Silk Pajama Button-Up Top

Writer Liza Corsillo says these separates are temperature regulating; they kept her warm on chilly nights and cool on hot ones. She likens their texture to “blueberries or grapes early in the morning that have a little frostiness to their skin.”

Writer Ambar Pardilla likes this sleep jumpsuit because it is “supersoft, worn-in, and doesn’t pill in the wash.” It’s also great for summer: “Without sleeves and with a low V-neck and keyhole in the back, the style is pretty airy.”

Please Advise

Which eyewear brands are making the best glasses these days.

in his most recent column, former glasses wearer (now LASIK evangelist) Chris Black pointed one reader toward four frames.

“I love these understated frames made of high-grade titanium. They are light and have some engraved details on the bridge and temples. A true everyday pair of glasses.”

Cutler and Gross 1409 Round Optical Glasses

“This style harkens back to movie stars of the 1950s. The glasses are handmade in Italy from a dark tortoise, which works well. Black would feel heavy.”

“Oliver Peoples is one of the most classic eyewear brands on earth, so it’s hard to choose just one style, but the Finley will look good on anyone.”

“I have had several pairs from Moscot in my time and can attest to their quality. This style is a slightly funky shape if you’re feeling playful.”

Testing, Testing

Here’s the only egg poacher that works.

When I started the process of finding the best egg poacher, I landed on eight models worth testing. I sent most of them out to colleagues and kept two options to test myself. When the results came in, the feedback was disappointing. The eggs either stuck to the contraptions or ended up soft-boiled, not poached. It wasn’t until I tested the final poacher that I found a beacon of hope. This bright-yellow OXO model is affordable and compact and, crucially, it works. It creates actual poached eggs with a fully liquid yolk that streams out beautifully upon contact with your fork. My set now has a permanent spot in my kitchen cabinet. — Emma Wartzman

Our Shopping Cart

A skin-clearing post-workout spray.

If I don’t immediately shower after hitting the gym, I wind up with a lot of pimples on my forehead. But then I heard that spritzing an antibacterial hypochlorous-acid mist post-workout — like Tower 28’s SOS spray ($28) — can help prevent clogged pores and breakouts. Intrigued, I found a $12 version from E11ement that has the same ingredients as the SOS spray and smells, pleasantly, like a chlorinated pool. The nozzle is powerful enough to put product on your face without it feeling like you just shot yourself in the eye with a water gun. After a few weeks of use, I’ve noticed that fewer whiteheads have cropped up. I’m excited to put it to the test this summer when I’m out and about and feeling sweaty. — Sam Daly

Compulsive Shopping

I can’t stop buying plug-in wall sconces.

I have a serious aversion to overhead lighting; it feels wrong and makes me twitch. Wall sconces are the ideal antidote, but installation can be expensive. This is why I love plug-in sconces. They’re perfect for renters and for homeowners who want atmospheric lighting without hiring a professional. These are the wall sconces I’ve used in my own home — and a couple I’m eyeing, too. — Fiona Byrne

Westinghouse Lighting 7-Inch Slimline Picture Light

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My acne journey
MY FULL DOXYCYCLINE EXPERIENCE FOR ACNE| Antibiotics for acne /Clearing
Acne Journey
Epiduo Forte / Doxycycline Acne Journey (4th Video)
3 Months on Doxycycline and Tretinoin Cleared My Acne
HOW I CLEARED UP MY ACNE

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Can Doxycycline Make Acne Worse?
Top 5 skin care hacks: acnes, pealing, medications, skin care routine [Vlog 205] SeraDanceVlogs

COMMENTS

Doxycycline for Acne: Everything to Know
Doxycycline is an oral antibiotic taken by mouth that is used to treat moderate to severe inflammatory acne. It can also be used to treat mild inflammatory acne that isn't getting better with other treatments. Inflammatory acne is the type in which bacteria inside a pore cause a red, swollen, pus-filled bump ( pustule ) on the skin.
Doxycycline For Acne: Benefits, Side Effects, and More
That being said, "doxycycline is the most commonly used oral antibiotic for acne due to its low side effect profile and efficacy in treating inflammatory acne," says Carqueville. Zeichner agrees: "It's an effective drug that has been used in dermatology for decades and has a proven safety record." Doxycycline is the generic name of the drug, by ...
Doxycycline for Acne: How Long Do Side Effects Last?
Doxycycline comes in a tablet or capsule that you take by mouth with a full glass of water. For acne, the typical dosage for doxycycline is 50 mg or 100 mg twice daily, or 100 mg once daily. But some forms of doxycycline are taken as 20 mg twice daily or 40 mg once daily. Doxycycline can cause nausea. If you experience this side effect, taking ...
Doxycycline for Acne: How It Works, Dosage, Side Effects
The dosage of doxycycline for acne varies by patient, but I typically recommend starting at a low dosage. Some doctors recommend 100mg a day or even twice a day, but I find that the side effects and impact on your microbiome are much more severe with this larger dose. A doxycycline dosage of between 20-50 mg daily is a good place to start.
Oral Doxycycline in the Management of Acne Vulgaris: Current
For approximately six decades, oral antibiotics have been used for the treatment of acne vulgaris (AV), primarily in patients with a predominance of inflammatory lesion involvement that is at least moderate in severity and/or in those who are poorly responsive to an adequate trial of topical therapy alone.1,2 From the mid-1950s through the early 1970s, the predominant oral antibiotics that ...
Doxycycline for Acne: Everything You Need to Know
December 9, 2021. Doxycycline is a common antibiotic that may be prescribed to treat acne. If your dermatologist or doctor has prescribed it to help address your severe acne, this article will explain how doxycycline works, how you should take it, and what side effects you might experience. You'll also know what you should not do while you ...
Oral Antibiotic Treatment Options for Acne Vulgaris
ORAL ANTIBIOTICS. The American Academy of Dermatology supports the use of oral antibiotics for treating moderate and severe acne, and oral antibiotics have been a mainstay of acne treatment for over 50 years.4 It is well-accepted that antibiotics are efficacious in reducing acne severity and have an overall acceptable safety profile. In recent years/decades, however, there has been growing ...
How doxycycline can help treat acne and rosacea
Studies show that doxycycline is effective in treating moderate inflammatory acne due to its anti-inflammatory effects.³. Helps treat rosacea. The anti-inflammatory properties of doxycycline also help calm inflammation caused by rosacea⁴ and reduce acne-like lesions.⁵. Improves red bumps, pimples, and redness.
Doxycycline for Acne: How It Works, Benefits, Side Effects & More
Doxycycline kills the Cutibacterium acnes or C. acnes (formerly Propionibacterium acnes) bacteria that proliferate in the skin. This bacteria causes the oil glands to produce more oil, which is one of the primary causes of acne and pimples. Due to how the medication works, doxycycline exhibits lower effectiveness in treating non-inflammatory ...
Doxycycline
Acne.org's Real World Take. Antibiotics should be used for a maximum of 3 months, provide only moderate benefit and only to some people, and may lead to side effects and strains of resistant bacteria. Studies do show doxycycline can reduce severe acne in the short term, and as far as oral antibiotics are concerned, it's usually the go-to, but ...
Doxycycline for Acne Treatment: A Comprehensive Guide
Struggling with acne can be a relentless and disheartening journey. After trying countless creams, gels, and cleansers without success, I finally gained control over my acne by using doxycycline. In this guide, I'll provide you all the essential information on successful use of doxycycline as an effective treatment for your skin condition - benefiting from its powerful antibacterial properties ...
Acne journey: month by month pictures using Doxycycline and Epiduo
Hello everyone! Here's a short video of my acne journey on doxycycline and Epiduo. I will be creating another video going more into detail regarding the pros...
4 Doxycycline Acne Purging Stages (Everything You Need to Know)
For many, this journey involves learning what they need to know about doxycycline, a common antibiotic used to treat severe acne. Doxycycline's role, its interaction with hormonal acne, its effectiveness, and the potential side effects it's likely to cause have been explored thoroughly.
Doxycycline for Acne: A Comprehensive Guide
Doxycycline, which has antimicrobial and anti-inflammatory properties, is also used to treat acne. It works by inhibiting the growth of Propionibacterium acnes (P. acnes), one of the main causes of acne. Furthermore, it has anti-inflammatory properties that can aid in the reduction of acne-related inflammation.
Can taking doxycycline for acne worsen my skin?
Doxycycline is usually well tolerated and is considered safe for dogs. It is widely prescribed for a range of different conditions such as bacterial infections and oral gum disease. Continue reading. Official answer: Often for people who take doxycycline for acne, the acne can become worse before it starts getting better, this is...
MY FULL DOXYCYCLINE EXPERIENCE FOR ACNE| Antibiotics for acne ...
This is my detailed experience with doxycycline for acne/antibiotics for acne. I was prescribed Doxycycline (doxy) 100mg for 3 months. I wanted to go through...
my hormonal acne skin journey
Hey guys, bit of a different video from me today but I thought it could help a lot of people! I had really bad hormonal acne from going onto the mini (proges...
Read This Before Taking Doxycycline For Acne
Before you decide to take doxycycline for acne, know the possible side effects that could happen first and consider other alternatives. Anyone who has ever had full on acne can tell you that sometimes all the standard topical treatments in the world aren't making much progress for their acne. When topical products aren't really helping acne ...
Doxycycline for Acne Reviews (Page 3)
Doxycycline for Acne User Reviews (Page 3) Brand names: Vibramycin, Monodox, Oracea, Adoxa, Doryx, …show all brand names. Doxycycline has an average rating of 6.8 out of 10 from a total of 714 reviews for the treatment of Acne. 53% of reviewers reported a positive experience, while 21% reported a negative experience.
[review] Doxycycline: short lived success : r/SkincareAddiction
Hello! I just wanted to share my experience with doxycycline to add to the collective skincare intelligence. Hopefully my personal account will be useful to someone else considering taking doxycycline. TL;DR: I took 100mg/day of doxycycline for 5 months and it completely cleared my acne. After 2 weeks off, my acne is coming back.
r/acne on Reddit: Doxycycline cycle for 6 months. First 2 pics are from
Doxycycline cycle for 6 months. First 2 pics are from October 2020, last 2 pics are present day. Started with 100 mgs first 3 months then 50 mgs last 3 months. Currently been off for 3 weeks and no new pimples so far. ... Good luck on your acne journey, I know how hard it can be but I promise it will get better! Reply reply
DOXYCYCLINE
Hi everybody out there! Just me coming at you with another ACNE update! Me and doxy have been together for 6 months now and we're coming to that stage where ...
What'd I Miss?: April 22, 2024
If you prefer to read in print, you can also find this article in the April 22, 2024, issue of New York Magazine. The Strategist is designed to surface the most useful, expert recommendations for ...
My Experience With Doxycycline For Acne. #acneprone #hormonalacne
Other Doxy/Differin Videos Antibiotics for Acne //Adapalene Gel ONE MONTH UPDATE https://youtu.be/iY2BLGAGM7Q STARTING DOXYCYCLINE VIDEO https://youtu.be/h...

Doxycycline for Acne: Everything to Know

Doxycycline Uses

Doxycycline Dosage and How to Use

Duration of Use

Click Play to Learn More About Doxycycline Acne Treatments

Who Should Not Take Doxycycline

Doxycycline Side Effects

Upset Stomach and Diarrhea

Esophagus Pain

Sensitivity to Sunlight

Can Doxycycline Make You Fat?

Doxycycline Interactions

Alternative Antibiotics for Acne

How Much Does Doxycycline Cost?

Doxycycline Is the Acne-Fighting Antibiotic Derms Want You to Know

What Is Doxycycline?

How It Treats Acne

Potential Side Effects

Related Stories

What is doxycycline?

How Doxycycline Treats Acne

Dosage of Doxycycline for Acne

What to Expect When Taking Doxycycline

How long does it usually take for doxycycline to work?

Doxycycline Side Effects

Drug Interactions

Is doxycycline right for you?

Oral Antibiotic Treatment Options for Acne Vulgaris

ORAL ANTIBIOTICS

HEAD-TO-HEAD TRIALS

ACKNOWLEDGEMENTS

Doxycycline for Acne: How It Works, Benefits, Side Effects & More

Table of Contents

What does doxycycline treat?

Doxycycline for Acne – What to Know

How Doxycycline Works for Acne

How Long Does Doxycycline Take to Work for Acne?

Doxycycline Dosage for Acne

How to Use Doxycycline for Acne

Warnings and Precautions

Common Side Effects of Doxycycline

Alternative Treatments for Acne

Frequently Asked Questions

How Long Does a UTI Last and How to Get Rid of It for Good

How Can Chlamydia Cause Infertility- What You Should Know

Bactrim For Sinus Infection: A Complete Usage Guide

Working Hours

Doxycycline for Acne Treatment: A Comprehensive Guide

Introduction to Doxycycline for Acne Treatment

How Doxycycline Works for Acne Treatment

Doxycycline Hyclate vs. Doxycycline Monohydrate: Which is Better for Acne Treatment?

Other Antibiotics Commonly Used for Acne Treatment

How Long Does Doxycycline Take to Work for Acne?

Common Side Effects of Doxycycline for Acne Treatment

How Long Do Doxycycline Side Effects Last?

Best Practices for Taking Doxycycline for Acne Treatment

When to Consider Doxycycline for Acne Treatment

Conclusion: Is Doxycycline a Good Option for Your Acne?

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4 Doxycycline Acne Purging Stages (Everything You Need to Know)

Biggest Take-Aways:

Stage 1: The Initiation Phase

Understanding Doxycycline

Skin Purging

Stage 2: The Purging Process

How Doxycycline Works in Purging

Stage 3: Stabilization

Improvement in Acne

Stage 4: Maintenance

Continuing Treatment