phenergan 10mg for travel sickness

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Phenergan (Promethazine) against motion sickness and nausea

The unpleasant symptoms of travel sickness (aeroplane, ship, car or bus) can be prevented by a drug called Phenergan. Its active ingredient is called Promethazine. It is an antihistamine that helps to prevent the effects of histamine in the body, helping you to avoid many unpleasant symptoms associated with travelling. It must be taken as a preventative measure to get the best possible effect to make the trip to the destination as easy going as possible.

What’s on this page?

How does phenergan work.

The active ingredient in this medicine is Promethazine. The focus of the treatment is the class of sedative antihistamines (calming antihistamine), after taking the pill it therefore prevents histamine from affecting. It can reduce the irritating symptoms associated with movement disorders such as nausea and dizziness. In order to fully understand how this drug works, we must first look at what the antihistamines are and how they work in the body.

How do antihistamines work in motion?

Histamines are natural substances in the body, usually found from the immune system. When the body experiences imbalance it releases histamine that binds to different receptors. This can then cause disturbing symptoms. For someone who is allergic to histamines, they can cause itching around the eyes and a runny nose, while others may have symptoms of motion sickness such as, nausea, vomiting and dizziness. Imbalance occurs when the eye sees a different movement than what the inner ear feels.

Antihistamines inhibit histamines from binding to certain receptors, so there is no “space” for histamines. When histamines cannot bind to these receptors, the symptoms of motion sickness are prevented.

The effect is best when the antihistamines are taken before the symptoms develop. In this way, histamines cannot bind in certain areas. However, it may also be helpful if the drug is taken after the onset of symptoms because the antihistamines are so powerful that they can push the histamine away from the receptors.

Sedative or soothing effect

Phenergan belongs to the category of sedative antihistamines, so it is not suitable to be used if you plan to drive a car. It can only be used if you are a passenger in a car or a ship, plane, train or bus. However, it should be noted that everyone feels the effects of Phenergan differently, so some might still be close to their normal state while others might feel very sleepy.

Phenergan 25 mg: How should I use it?

This medicine is available in various forms, both in tablets and as an oral solution. The oral solution is typically used by children – however, only according to the doctor’s instructions. The tablets for adults contain 25 mg of the active substance and are taken with a glass water.

For the best effect, it is best to take the tablet before the start of the movement, i.e. about 30 to 60 minutes before the expected start. The effects of the medicine last around 5 to 14 hours in the blood stream and therefore it lasts during the whole trip for most people.

Remember that you may become very drowsy and your muscles may become tired after taking the medicine. However, the effect may differ between people and after you have used it a couple of times. After use, you can quickly understand how much the medicine affects you.

Alcohol can weaken the effects of the drug and therefore it is not recommended to drink alcohol and use the medicine simultaneously.

Are there any side effects?

All medicines can cause side effects to some extent. This is, among other things, the reason why most medicines can only be purchased with a prescription from a doctor. This also applies to Phenergan, although most do not experience any side effects. The most common side effects are a dry mouth and feeling fatigue, as mentioned earlier. Some have side effects such as dizziness, lack of urination, blurred vision and confusion. Rare side effects include anemia and allergic reactions. If you notice any serious side effects, contact your doctor immediately.

Is Phenergan suitable for me?

Most people who suffer from motion sickness while travelling either on the sea or in the air can take advantage of this medicine. However, care should be taken with regard to the simultaneous use of other medicines or other conditions you might be experiencing. This applies to situations in which you have sleep apnea, impaired hepatic or renal function or glaucoma. In addition, it may also affect with many antidepressants and sedatives.

Is there other natural options for Phenergan?

In addition to preventative medicines, there are other measures you can take to reduce discomfort during the movement:

make sure you get enough rest before your trip
drink a lot of water
if possible, get fresh air – stop the car and have breaks while driving, spend time up on the deck while on a ship or try to go out from the airport
be sure to look out from the window and avoid reading

Can I buy Phenergan online?

Phenergan is a prescription medication. You can visit your doctor and get a prescription that you can then use in a pharmacy when buying the medicine. Another possibility is to purchase the drug through an approved online clinic where your doctor will digitally assess whether the medicine is suitable for you or not. If the drug is right for you, you get a digital prescription and the medication can be sent to your home. This process saves you a lot of time, as you do not have to book a time from the doctor or go to the clinic physically.

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Promethazine (Oral Route)

Drug information provided by: Merative, Micromedex ®

This medicine can be taken with food or a glass of water or milk to lessen stomach irritation if necessary.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Adults and teenagers—12.5 milligrams (mg) before meals and at bedtime; or 25 mg at bedtime as needed.
Children 2 years of age and older—Your doctor will determine dose based on the weight and/or size of the child. The dose is usually 6.25 to 12.5 mg three times a day; or 25 mg at bedtime as needed.
Children younger than 2 years of age—Use and dose must be determined by your doctor .
Adults and teenagers—25 mg twice daily; this initial dose should be taken one-half to one hour before traveling. The dose may be repeated eight to twelve hours later if needed. On other days of travel, 25 mg may be taken on arising and again before the evening meal.
Children 2 years of age and older—Your doctor will determine dose based on the weight and/or size of the child. The dose is usually 12.5 to 25 mg one-half to one hour before traveling. The dose may be repeated eight to twelve hours later if needed.
Adults and teenagers—25 mg for the first dose, then 12.5 to 25 mg every four to six hours if needed.
Children 2 years of age and older—Your doctor will determine dose based on the weight and/or size of the child. The dose is usually 0.5 mg per pound of body weight (1.1 mg per kg) or 12.5 to 25 mg every four to six hours as needed.
Adults and teenagers—25 to 50 mg.
Children 2 years of age and older—Your doctor will determine dose based on the weight and/or size of the child. The dose is usually 12.5 to 25 mg.
Adults and teenagers—50 mg the night before surgery; 25 to 50 mg after surgery.
Children 2 years of age and older—Your doctor will determine dose based on the weight and/or size of the child. The dose is usually 0.5 mg per pound of body weight (1.1 mg per kg) or 12.5 to 25 mg the night before surgery or after the surgery.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Do not keep outdated medicine or medicine no longer needed.

Keep out of the reach of children.

Before Using
Precautions

Portions of this document last updated: April 01, 2024

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Promethazine

Avomine, phenergan, sominex.

Peer reviewed by Sid Dajani Last updated by Michael Stewart, MRPharmS Last updated 18 Mar 2023

Meets Patient’s editorial guidelines

Promethazine is an antihistamine.

You may need to take one or more doses during a day, depending upon the reason you are taking it. Make sure you carefully follow the directions on the label.

Promethazine may affect your ability to drive and to use tools or machines.

The most common side-effects are feeling sleepy, headache, dry mouth and blurred vision.

Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. There are a number of different brands and strengths of promethazine tablet. The manufacturer's leaflet will give you more information about the brand you have been given. It will also contain a full list of the side-effects which you may experience from taking promethazine.

Take promethazine exactly as your doctor or pharmacist has told you to. You may be asked to take one or more doses during a day, depending upon the reason why you are taking it.

If you are taking promethazine to prevent travel sickness, it is usually recommended that you take the first dose at bedtime on the evening before you are due to travel. You can then take a further dose on the morning of your travel if needed.

You can take promethazine before or after meals. Some people find it helps to swallow the tablets with a drink of water.

If you are giving promethazine liquid medicine to a child, make sure you follow the dosing instructions on the bottle carefully so that you measure out the correct dose for the age of your child.

Most people only need to take an antihistamine for a short while when they have symptoms. You should stop taking promethazine once your symptoms have eased. Do not take promethazine for more than a few days for sleeping problems.

Promethazine may cause drowsiness and blurred vision. If this happens to you, do not drive and do not use tools or machines. Alcohol will make the drowsiness worse, so it is best not to drink alcohol while you are on promethazine.

If you are pregnant, only take promethazine on the advice of your doctor. Do not take promethazine in the last two weeks before your baby is born as it could cause side-effects for your baby.

If you are having an operation or any treatment (particularly if it is to test for an allergy), tell the person carrying out the treatment that you are taking promethazine.

Promethazine may cause your skin to become more sensitive to sunlight than normal. Use a sunscreen that protects against UVA light and has a sun protection factor (SPF) of at least 15, especially in strong sunlight or until you know how your skin reacts. Do not use sunbeds.

If you buy any medicines, check with a pharmacist that they are safe to take with an antihistamine. This is because a number of other medicines can interfere with the way promethazine works and can increase the risk of side-effects.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with promethazine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any continue or become troublesome.

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

Keep all medicines out of the reach and sight of children.

Store in a cool, dry place, away from direct heat and light.

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Report side effects to a medicine or vaccine

If you experience side effects, you can report them online through the Yellow Card website .

Article History

The information on this page is written and peer reviewed by qualified clinicians.

Next review due: 17 Mar 2026

18 mar 2023 | latest version.

Last updated by

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Promethazine (Phenergan) - Other brand names: Avomine, Sominex

On this page.

About promethazine
Who can and cannot take promethazine
How and when to take promethazine
Side effects
How to cope with side effects of promethazine
Pregnancy and breastfeeding
Cautions with other medicines
Common questions about promethazine

1. About promethazine

Promethazine is an antihistamine medicine that relieves the symptoms of allergies.

It's known as a drowsy (sedating) antihistamine, so it's more likely to make you feel sleepy than other antihistamines.

Promethazine is used for:

short-term sleep problems ( insomnia ) – including when a cough, cold or itching is keeping you awake at night
allergies, including hay fever and hives (urticaria)
feeling and being sick (vomiting) – due to motion sickness or vertigo
cold symptoms, such as coughing and a runny nose

You can buy promethazine from pharmacies, where it's often sold as Avomine, Phenergan or Sominex. Promethazine is also available on prescription.

It comes as tablets, capsules and a liquid that you swallow.

You can also buy promethazine mixed with other medicines, such as paracetamol , dextromethorphan or pseudoephedrine, to treat coughs and colds or pain.

2. Key facts

Do not drink alcohol while taking promethazine. Alcohol increases the risks of side effects.
To help you sleep, take promethazine 20 minutes before you go to bed. It normally takes about 30 minutes to work.
To prevent motion sickness, take promethazine the night before a long journey or 1 to 2 hours before a short journey.
Common side effects of promethazine include drowsiness, headaches, nightmares and feeling dizzy, restless or confused.
When promethazine is mixed with other medicines, it's also known by the brand names Fedril and Night Nurse.

3. Who can and cannot take promethazine

Promethazine can be taken by most adults.

Children under 6 should not be given cough and cold medicines containing promethazine if they have been bought at a pharmacy. These medicines should only be given if prescribed by a doctor.

Some types of promethazine medicines are not suitable for children over 6. Some are labelled 12+ and some are labelled 16+. Your doctor or pharmacist will advise which are the safest for children.

Promethazine is not suitable for some adults. To make sure it's safe for you, tell your doctor or pharmacist if you:

have ever had an allergic reaction to promethazine or any other medicine
have an eye problem called primary angle closure glaucoma
have problems peeing or emptying your bladder
have epilepsy or any other health problem that causes seizures or fits
are due to have an allergy test. Promethazine can affect your results, so you may need to stop taking it a few days before your test. Ask the clinic where you are due to have your allergy test
are unable to have any alcohol – some liquid promethazine products contain a very small amount of alcohol, so check the ingredients and the packaging carefully
are trying to get pregnant. Promethazine can affect home pregnancy tests. If you think you're pregnant, speak to your doctor so they can arrange a blood test instead

4. How and when to take promethazine

If you or your child have been prescribed promethazine, follow your doctor's instructions about how and when to take it.

Only take promethazine when you need it – for example, if you're unable to sleep because you're worrying about something or your cold symptoms are keeping you awake.

If you have bought promethazine or any medicine containing promethazine from a pharmacy, follow the instructions that come with it, or ask a pharmacist for advice.

Dosage and strength

Promethazine comes in 10mg, 20mg and 25mg tablets. Your dose depends on why you're taking it:

short-term insomnia – you'll usually take 20mg to 50mg at night
hay fever – you'll usually take from 10mg twice a day to 20mg, 3 times a day
hives – you'll usually take from 10mg twice a day to 20mg 3 times a day
preventing motion sickness – you'll usually take 25mg 1 to 2 hours before a short journey or 25mg the night before a long journey
treating motion sickness – take 25mg as soon as possible and 25mg the same evening, followed by 25mg the following evening (if you need it)
vertigo – the dose can vary from 25mg a day to 25mg 4 times a day

If you're taking liquid which contains 5mg of promethazine in 5ml, follow the instructions that come with the medicine for how much to take.

Doses are lower for children. Your doctor will use your child's age to work out the right dose.

Promethazine mixed with other medicines

Promethazine can come mixed with other medicines, such as paracetamol. This is usually used to treat cough and cold symptoms. Your dose will depend on the type of medicine you're taking.

Check the instructions on the packaging carefully, or ask your pharmacist or doctor if you're unsure.

How to take it

You can take promethazine tablets, capsules and liquid with or without food.

How to take tablets and capsules

Always take your promethazine tablets or capsules with a drink of water. Swallow them whole. Do not chew them.

How to take liquid

Liquid medicines containing promethazine come with a plastic syringe or spoon to help you measure out the right dose.

If you do not have a syringe or spoon, ask your pharmacist for one. Do not use a kitchen teaspoon as you will not get the right amount.

What if I forget to take it?

For motion sickness, take it as soon as you remember.

For anything else, skip the missed dose and take your next dose at the usual time.

Never take 2 doses at the same time. Never take an extra dose to make up for a forgotten one.

If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

What if I take too much?

Too much promethazine can be dangerous.

If you take more than your usual dose, you may:

feel very sleepy
have a very fast, irregular or pounding heartbeat (palpitations)
have breathing problems

In serious cases, you can become unconscious or have seizures or fits and may need emergency treatment in hospital.

If your child takes too much promethazine, they may also:

move unsteadily or stumble
have uncontrolled movements, especially in their hands or feet
see or hear things that are not there (hallucinations)
have an irregular heartbeat

Urgent advice: Contact 111 for advice if:

you take more than your usual dose of promethazine

Go to 111.nhs.uk or call 111

If you need to go to A&E do not drive yourself. Get someone else to drive you or call for an ambulance.

Take the promethazine packet or leaflet inside it, plus any remaining medicine, with you.

5. Side effects

Common side effects.

Like all medicines, promethazine can cause side effects, although not everyone gets them.

Talk to your pharmacist or doctor if these side effects bother you or do not go away:

feeling tired during the daytime
feeling dizzy or unsteady on your feet, or having difficulty concentrating

Promethazine can sometimes make your skin more sensitive to sunlight. Keep out of direct or strong sunlight and follow sun safety advice .

If you're over 65, you're more likely to get side effects such as:

feeling confused
blurred vision
difficulty peeing

Talk to a doctor or call 111 straight away if you have these side effects.

Children are more likely to get side effects such as feeling restless or excited.

Serious side effects

Call your doctor straight away if:

the whites of your eyes or your skin turn yellow, although this may be less obvious on black or brown skin – these can be signs of liver problems
you notice more bruising or bleeding than normal
you have muscle stiffness or shaking, or unusual face or tongue movements

Serious allergic reaction

In rare cases, it's possible to have a serious allergic reaction ( anaphylaxis ) to promethazine.

Immediate action required: Call 999 now if:

your lips, mouth, throat or tongue suddenly become swollen
you're breathing very fast or struggling to breathe (you may become very wheezy or feel like you're choking or gasping for air)
your throat feels tight or you're struggling to swallow
your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
you suddenly become very confused, drowsy or dizzy
someone faints and cannot be woken up
a child is limp, floppy or not responding like they normally do (their head may fall to the side, backwards or forwards, or they may find it difficult to lift their head or focus on your face)

You or the person who's unwell may also have a rash that's swollen, raised, itchy, blistered or peeling.

These can be signs of a serious allergic reaction and may need immediate treatment in hospital.

These are not all the side effects of promethazine. For a full list, see the leaflet inside your medicine packet.

You can report any suspected side effect using the Yellow Card safety scheme.

Visit Yellow Card for further information .

6. How to cope with side effects of promethazine

What to do about:

feeling sleepy during the daytime – this usually wears off 12 hours after a dose. Do not drive, cycle or use tools or machinery if you're feeling this way.
nightmares – speak to your pharmacist or doctor if these do not go away or are troubling you.
feeling dizzy or unsteady on your feet, or having difficulty concentrating – stop what you're doing and sit or lie down until you feel better. If the feeling does not go away or is troubling you, do not take any more medicine and speak to a pharmacist or doctor.
headaches – make sure you rest and drink plenty of fluids. Talk to your doctor if the headaches last longer than a week or are severe.

7. Pregnancy and breastfeeding

Promethazine and pregnancy.

Promethazine can be used in pregnancy. There is no good evidence that it is harmful to your baby, but it can have side effects such as drowsiness.

For the treatment of hay fever your doctor or pharmacist may recommend a non-drowsy antihistamine ( loratadine ).

Promethazine and breastfeeding

If your doctor or health visitor says your baby is healthy, promethazine can be used during breastfeeding. If you are prescribed promethazine, it's better to take occasional doses or only for a short time.

It's not known how much promethazine passes into breast milk but it is likely to be a small amount. It has been used for many years without causing babies to have side effects. However, promethazine is a drowsy antihistamine, so may also make your baby sleepy too. It may also reduce the amount of milk you produce.

If you're breastfeeding or planning to breastfeed, talk to your doctor or pharmacist, as other medicines might be better while you're breastfeeding.

If your baby is not feeding as well as usual, seems unusually sleepy, or seems irritable, or if you have any other concerns about your baby, talk to your doctor, pharmacist, health visitor or midwife.

Non-urgent advice: Tell your doctor if you're:

trying to get pregnant
breastfeeding

Find out more about how promethazine can affect you and your baby during pregnancy on the Best Use of Medicines in Pregnancy (BUMPs) website.

8. Cautions with other medicines

Some medicines and promethazine can affect each other and increase the chance of having side effects.

Tell your pharmacist or doctor if you're taking:

a type of antidepressant called a monoamine oxidase inhibitor, such as phenelzine
a type of painkiller called an opioid, such as codeine , morphine or oxycodone
any medicine that makes you drowsy, gives you a dry mouth, or makes it difficult for you to pee – taking promethazine might make these side effects worse

If you're taking a cough or cold remedy or a painkiller containing promethazine, check carefully what the other ingredients are.

For example, promethazine often comes mixed with paracetamol . If you take 2 medicines that both contain paracetamol, there's a risk of overdose.

Ask your pharmacist for advice before you take this medicine together with any other painkillers or medicines.

Mixing promethazine with herbal remedies and supplements

There might be a problem taking some herbal remedies and supplements alongside promethazine, especially ones that cause side effects such as sleepiness, a dry mouth or making it difficult to pee.

Ask your pharmacist for advice.

Important: Medicine safety

Tell your doctor or pharmacist if you're taking any other medicines, including herbal medicines, vitamins or supplements.

9. Common questions about promethazine

Promethazine is a medicine called an antihistamine . It's classed as a drowsy (sedating) antihistamine.

When you come into contact with something you're allergic to, such as pollen or animal hair, your body produces a chemical called histamine. This can cause symptoms such as a runny nose or skin rashes.

Promethazine blocks the effects of histamine in your brain and this reduces symptoms.

It enters the brain in large quantities and this can make you feel drowsy.

Promethazine also blocks the effects of a chemical called dopamine, and this stops you feeling sick.

Promethazine blocks the effects of a natural chemical called acetylcholine.

This can help dry up a cough or runny nose, but can also cause side effects such as a dry mouth and dry nose.

Some cough and cold remedies claim to suppress your cough or stop you bringing up phlegm.

Although some people find them helpful, they're not usually recommended.

This is because there's little evidence that they're any more effective than simple home remedies and they're not suitable for everyone.

Promethazine will start to make you feel sleepy around 20 minutes after you take it and may work for up to 12 hours.

If you're taking it for a cough or cold, allergies or feeling sick (nausea), your symptoms should start to improve within 20 minutes. The medicine should work for around 4 to 6 hours.

Only take promethazine for a short time, unless your doctor says it's OK for you to take it for longer.

Speak to your pharmacist or doctor before taking promethazine for longer than the medicine leaflet recommends.

Ask them for advice if you're unsure how long you should take it for.

It's unlikely that you'll get addicted to promethazine. But it's best that you only take it for a very short time, unless your doctor tells you to take it for longer.

If you have bought a medicine containing promethazine, do not take it for longer than recommended on the packet without speaking to your pharmacist or doctor first.

If you have taken promethazine for a long time and suddenly stop taking it, it's possible you might feel dizzy, sweaty or sick, have a racing heart and have trouble sleeping.

Coming off promethazine slowly can help prevent this.

Speak to your doctor if you have taken promethazine for a long time and want to stop taking it.

Promethazine is known as a drowsy (sedating) antihistamine as it makes you sleepy.

Non-drowsy antihistamines are less likely to have this effect. These include cetirizine , fexofenadine and loratadine .

Most people prefer to take a non-drowsy antihistamine as it's less likely to interfere with their everyday routine.

You might choose to take a drowsy antihistamine, however, if you're having problems falling asleep, or if symptoms like itching or coughing are keeping you awake.

There is not enough information available to say whether one antihistamine is better than another for treating allergies.

You may need to try a few different medicines to find what works best for you. Ask your pharmacist or doctor for advice if you're unsure.

You can take 2 different antihistamines at a time, if your doctor says it's OK. If you have a severe itchy skin rash, your doctor may recommend 2 different antihistamines together for a few days.

You could take a non-drowsy antihistamine (such as cetirizine , fexofenadine or loratadine ) during the day, and a drowsy antihistamine at night if itching is making it difficult to sleep.

Do not take another drowsy antihistamine together with promethazine. It'll make you very tired and sleepy.

Other drowsy antihistamines include chlorphenamine (Piriton) and diphenhydramine (Nytol Original).

Do not take 2 antihistamines together unless you have been advised to by your doctor.

Yes. If you take it for insomnia or take it at bedtime, promethazine will help you sleep.

If you take it during the day for other conditions, such as allergies, it might make you feel sleepy during the day as well.

Yes, you can take promethazine together with some painkillers, such as paracetamol or ibuprofen .

If you take promethazine with painkillers that contain codeine (such as co-codamol or other prescription painkillers), you may feel very tired and sleepy.

It's important to check the packaging or label of your medicine carefully. This is because some promethazine products already contain a painkiller.

Do not take extra painkillers if this is the case, as there's a risk of overdose.

Speak to your pharmacist if you're not sure whether a medicine already contains a painkiller.

Do not drive a car or ride a bike if promethazine makes you sleepy during the daytime, gives you blurred vision or makes you feel dizzy, clumsy or unable to concentrate or make decisions.

This may be more likely when you first start taking promethazine, but could happen at any time (for example, when starting another medicine).

It's an offence to drive a car if your ability to drive safely is affected. It's your responsibility to decide if it's safe to drive. If you're in any doubt, do not drive.

Talk to your doctor or pharmacist if you're unsure whether it's safe for you to drive while taking promethazine. GOV.UK has more information on the law on drugs and driving .

There's no evidence to suggest that taking promethazine reduces fertility in either men or women.

But speak to a pharmacist or doctor before taking it if you're trying to get pregnant.

Promethazine does not affect any type of contraception, including the combined pill and emergency contraception .

Do not drink alcohol while you're taking promethazine.

Alcohol and promethazine together can make you sleep very deeply.

You will not be able to breathe properly and may have difficulty waking up.

You can eat normally while taking promethazine.

However, do not drink alcohol. And if you take promethazine to help you sleep, try not to have drinks that contain caffeine, like coffee, tea, cola or energy drinks. Caffeine has the opposite effect to promethazine and can stop the medicine working.

Yes, it's dangerous to take promethazine with recreational drugs. This is because it can slow or stop your heart and lungs.

Mixing promethazine and codeine in large amounts slows down the central nervous system (brain and spinal cord), which can slow breathing and heart rate.

It's even more dangerous when taken with alcohol or other drugs and has caused people to die.

Find out more about the side effects of some recreational drugs on the Frank website .

Promethazine will only help you sleep while you're taking it, so there are a number of things you can do instead to help yourself have a good night's sleep :

set regular times for going to bed and waking up
relax before bedtime – try taking a warm bath or listening to calming music
use thick curtains or blinds, an eye mask and earplugs to stop you being woken up by light and noise
avoid caffeine, cigarettes or vapes, alcohol, heavy meals and exercise for a few hours before bedtime
do not watch TV or use phones, tablets or computers before going to bed
do not nap during the day
make a list of your worries and any ideas for how to solve them before you go to bed – this can help you forget about them until the morning

If you have hay fever , it helps if you do not spend too much time outside if the pollen count is high.

Tips for when you're outside

Do not cut grass or walk on grass.
Wear wraparound sunglasses to stop pollen getting into your eyes.
Put Vaseline around your nostrils to help trap pollen.
Shower and change your clothes after you have been outside to wash off pollen.

Tips for when you're inside

Keep windows and doors shut as much as possible.
Vacuum regularly and dust with a damp cloth.
Do not keep fresh flowers in the house.
Do not smoke or be around smoke as it makes hay fever symptoms worse.

The best way to prevent any sort of allergic reaction is to avoid the substance that you're allergic to, if you can.

There are some practical steps you can follow to help prevent allergies .

Related conditions

Contact dermatitis
Motion sickness

Useful resources

Allergy UK: charity
Healthtalk: videos of real stories about sleep problems
Itchy Sneezy Wheezy: website for parents

Page last reviewed: 27 October 2021 Next review due: 27 October 2024

ANDREW BRAINARD, MD, MPH, AND CHIP GRESHAM, MD

Am Fam Physician. 2014;90(1):41-46

Patient information : See related handout on motion sickness , written by the authors of this article.

Author disclosure: No relevant financial affiliations.

Motion sickness is a common syndrome that occurs upon exposure to certain types of motion. It is thought to be caused by conflict between the vestibular, visual, and other proprioceptive systems. Although nausea is the hallmark symptom, it is often preceded by stomach awareness, malaise, drowsiness, and irritability. Early self-diagnosis should be emphasized, and patients should be counseled about behavioral and pharmacologic strategies to prevent motion sickness before traveling. Patients should learn to identify situations that will lead to motion sickness and minimize the amount of unpleasant motion they are exposed to by avoiding difficult conditions while traveling or by positioning themselves in the most stable part of the vehicle. Slow, intermittent exposure to the motion can reduce symptoms. Other behavioral strategies include watching the true visual horizon, steering the vehicle, tilting their head into turns, or lying down with their eyes closed. Patients should also attempt to reduce other sources of physical, mental, and emotional discomfort. Scopolamine is a first-line medication for prevention of motion sickness and should be administered transdermally several hours before the anticipated motion exposure. First-generation antihistamines, although sedating, are also effective. Nonsedating antihistamines, ondansetron, and ginger root are not effective in the prevention and treatment of motion sickness.

Motion sickness is a syndrome that occurs when a patient is exposed to certain types of motion and usually resolves soon after its cessation. It is a common response to motion stimuli during travel. Although nausea is a hallmark symptom, the syndrome includes symptoms ranging from vague malaise to completely incapacitating illness. These symptoms, which can affect the patient's recreation, employment, and personal safety, can occur within minutes of experiencing motion and can last for several hours after its cessation.

Nearly all persons will have symptoms in response to severe motion stimuli, and a history of motion sickness best predicts future symptoms. 1 Females, children two to 15 years of age, and persons with conditions associated with nausea (e.g., early pregnancy, migraines, vestibular syndromes) report increased susceptibility.

The pathogenesis of motion sickness is not clearly understood, but it is thought to be related to conflict between the vestibular, visual, and other proprioceptive systems. 2 Rotary, vertical, and low-frequency motions produce more symptoms than linear, horizontal, and high-frequency motions. 1

Clinical Presentation

Although nausea may be the first recognized symptom of motion sickness, it is almost always preceded by other subtle symptoms such as stomach awareness (i.e., a sensation of fullness in the epigastrium), malaise, drowsiness, and irritability. Failure to attribute early symptoms to motion sickness may lead to delays in diagnosis and treatment. Although mild symptoms are common, severely debilitating symptoms are rare 2 ( Table 1 1 , 2 ) .

Behavioral Interventions

Prevention of motion sickness is more effective than treating symptoms after they have occurred. Therefore, patients should learn to identify situations that may lead to motion sickness and be able to initiate behavioral strategies to prevent or minimize symptoms 1 , 2 ( Table 2 1 – 13 ) .

MINIMIZE VESTIBULAR MOTION

Patients should be advised to avoid traveling in difficult weather conditions. If they must travel, they should sit in the part of the vehicle with the least amount of rotational and vertical motion. 2 This is usually the lowest level in trains and buses, close to water level and in the center of boats, and over the wing on airplanes.

HABITUATE TO MOTION

With continuous exposure to motion, symptoms of motion sickness will usually subside in one to two days. Alternatively, slow, intermittent habituation to motion is an effective strategy to reduce symptoms. 1 For example, spending the first night aboard a boat in the marina, followed by a day acclimating in the harbor, is preferable to going straight into the open ocean.

SYNCHRONIZE THE VISUAL SYSTEM WITH THE MOTION

A small study found that focusing on the true horizon (skyline) minimized symptoms of motion sickness. 5 A survey of 3,256 bus passengers suggested that forward vision was helpful in reducing symptoms. 3 Another study indicated that forward vision in a car can reduce symptoms. 4

ACTIVELY SYNCHRONIZE THE BODY WITH THE MOTION

Actively steering the vehicle is an accepted strategy for reducing symptoms of motion sickness, although evidence is limited. 7 Additionally, a small study of automobile passengers found that actively tilting the head into turns was effective in preventing symptoms. 6 A survey of 260 cruise ship passengers supported the common advice to recline and passively stabilize themselves if they are unable to initiate active movements. 8

REDUCE OTHER SOURCES OF PHYSICAL, MENTAL, AND EMOTIONAL DISCOMFORT

Frequent consumption of light, soft, bland, low-fat, and low-acid food can minimize symptoms of motion sickness. 2 Treating gastritis is useful, 2 as is avoiding nausea-inducing stimuli (e.g., alcohol, noxious odors). Discussing symptoms with others can exacerbate the condition. Passengers should be well rested, well hydrated, well fed, and comfortable before beginning travel. Small studies have shown that cognitive behavior therapy, mindful breathing, and listening to music may also reduce symptoms of motion sickness. 9 , 10 , 13

Medications

Medications are most effective when taken prophylactically before traveling, or as soon as possible after the onset of symptoms 2 ( Table 3 1 , 2 , 14 – 23 ) . Medications are most effective when combined with behavioral strategies. To familiarize themselves with common side effects, patients should first take medications in a comfortable environment before using them for motion sickness during travel.

SCOPOLAMINE

Scopolamine, an anticholinergic, is a first-line option for preventing motion sickness in persons who wish to maintain wakefulness during travel. 2 , 20 , 24 A Cochrane review of 14 randomized controlled trials (RCTs) showed that scopolamine is effective for the prevention of motion sickness. 14 A more recent RCT of 76 naval crew members showed that transdermal scopolamine is more effective and has fewer side effects than the antihistamine cinnarizine (not available in the United States). 15 If the recommended dose of scopolamine does not adequately relieve symptoms, the dose may be doubled. Adding a second patch of transdermal scopolamine was well tolerated in a small RCT of 20 sailors. 25

ANTIHISTAMINES

First-generation antihistamines have been used to treat motion sickness since the 1940s. 1 They are generally recommended for patients who can tolerate their sedative effects. 2 , 20 Cyclizine (Marezine), dimenhydrinate, promethazine, and meclizine (Antivert) demonstrated effectiveness in small RCTs of varying quality. 16 – 19 Nonsedating antihistamines are not effective in preventing or treating motion sickness. 26

OTHER MEDICATIONS

Benzodiazepines are occasionally administered for severe symptoms of motion sickness and have been proven effective in a single small study. 27 The serotonin agonist rizatriptan (Maxalt) reduced motion sickness symptoms in a single RCT of 25 patients with recurrent migraines. 28 The serotonin antagonist ondansetron (Zofran) is ineffective for the prevention and treatment of motion sickness. 29 , 30

COMPLEMENTARY AND ALTERNATIVE THERAPIES

Although ginger root is often reported to prevent motion sickness, it had no statistically significant effects in an RCT of 80 naval cadets. 31 A single RCT of pregnant women showed that stimulation of the P6 acupressure point on the anterior wrist increased their tolerance of motion stimuli. 32 Controlled trials of behavioral, pharmacologic, or alternative therapies for motion sickness have demonstrated strong placebo effects. Therefore, treatments are likely to be most effective if the patient believes that they will work. 11 , 12

Data Sources : PubMed was searched using the MeSH headings motion sickness, ships, movement, space motion sickness, and travel. Additional searches were performed in Essential Evidence Plus, UpToDate, Medscape, and BMJ Clinical Evidence. Search dates: March 2012 through March 2014.

Golding JF. Motion sickness susceptibility. Auton Neurosci. 2006;129(1–2):67-76.

Shupak A, Gordon CR. Motion sickness: advances in pathogenesis, prediction, prevention, and treatment. Aviat Space Environ Med. 2006;77(12):1213-1223.

Turner M, Griffin MJ. Motion sickness in public road transport: the relative importance of motion, vision and individual differences. Br J Psychol. 1999;90(pt 4):519-530.

Griffin MJ, Newman MM. Visual field effects on motion sickness in cars. Aviat Space Environ Med. 2004;75(9):739-748.

Bos JE, MacKinnon SN, Patterson A. Motion sickness symptoms in a ship motion simulator: effects of inside, outside, and no view. Aviat Space Environ Med. 2005;76(12):1111-1118.

Wada T, Konno H, Fujisawa S, Doi S. Can passengers' active head tilt decrease the severity of carsickness? Effect of head tilt on severity of motion sickness in a lateral acceleration environment. Hum Factors. 2012;54(2):226-234.

Rolnick A, Lubow RE. Why is the driver rarely motion sick? The role of controllability in motion sickness. Ergonomics. 1991;34(7):867-879.

Gahlinger PM. Cabin location and the likelihood of motion sickness in cruise ship passengers. J Travel Med. 2000;7(3):120-124.

Dobie TG, May JG. The effectiveness of a motion sickness counselling programme. Br J Clin Psychol. 1995;34(pt 2):301-311.

Yen Pik Sang FD, Billar JP, Golding JF, Gresty MA. Behavioral methods of alleviating motion sickness: effectiveness of controlled breathing and a music audiotape. J Travel Med. 2003;10(2):108-111.

Horing B, Weimer K, Schrade D, et al. Reduction of motion sickness with an enhanced placebo instruction: an experimental study with healthy participants. Psychosom Med. 2013;75(5):497-504.

Eden D, Zuk Y. Seasickness as a self-fulfilling prophecy: raising self-efficacy to boost performance at sea. J Appl Psychol. 1995;80(5):628-635.

Denise P, Vouriot A, Normand H, Golding JF, Gresty MA. Effect of temporal relationship between respiration and body motion on motion sickness. Auton Neurosci. 2009;151(2):142-146.

Spinks A, Wasiak J. Scopolamine (hyoscine) for preventing and treating motion sickness. Cochrane Database Syst Rev. 2011;6:CD002851.

Gil A, Nachum Z, Tal D, Shupak A. A comparison of cinnarizine and transdermal scopolamine for the prevention of seasickness in naval crew: a double-blind, randomized, crossover study. Clin Neuropharmacol. 2012;35(1):37-39.

Estrada A, LeDuc PA, Curry IP, Phelps SE, Fuller DR. Airsickness prevention in helicopter passengers. Aviat Space Environ Med. 2007;78(4):408-413.

Brand JJ, Colquhoun WP, Gould AH, Perry WL. (—)-Hyoscine and cyclizine as motion sickness remedies. Br J Pharmacol Chemother. 1967;30(3):463-469.

Weinstein SE, Stern RM. Comparison of marezine and dramamine in preventing symptoms of motion sickness. Aviat Space Environ Med. 1997;68(10):890-894.

Paul MA, MacLellan M, Gray G. Motion-sickness medications for aircrew: impact on psychomotor performance. Aviat Space Environ Med. 2005;76(6):560-565.

Sherman CR. Motion sickness: review of causes and preventive strategies. J Travel Med. 2002;9(5):251-256.

Zajonc TP, Roland PS. Vertigo and motion sickness. Part II: pharmacologic treatment. Ear Nose Throat J. 2006;85(1):25-35.

Gordon CR, Shupak A. Prevention and treatment of motion sickness in children. CNS Drugs. 1999;12(5):369-381.

McDonald K, Trick L, Boyle J. Sedation and antihistamines: an update. Review of inter-drug differences using proportional impairment ratios. Hum Psychopharmacol. 2008;23(7):555-570.

Nachum Z, Shupak A, Gordon CR. Transdermal scopolamine for prevention of motion sickness: clinical pharmacokinetics and therapeutic applications. Clin Pharmacokinet. 2006;45(6):543-566.

Bar R, Gil A, Tal D. Safety of double-dose transdermal scopolamine. Pharmacotherapy. 2009;29(9):1082-1088.

Cheung BS, Heskin R, Hofer KD. Failure of cetirizine and fexofenadine to prevent motion sickness. Ann Pharmacother. 2003;37(2):173-177.

McClure JA, Lycett P, Baskerville JC. Diazepam as an anti-motion sickness drug. J Otolaryngol. 1982;11(4):253-259.

Furman JM, Marcus DA, Balaban CD. Rizatriptan reduces vestibular-induced motion sickness in migraineurs. J Headache Pain. 2011;12(1):81-88.

Muth ER, Elkins AN. High dose ondansetron for reducing motion sickness in highly susceptible subjects. Aviat Space Environ Med. 2007;78(7):686-692.

Hershkovitz D, Asna N, Shupak A, Kaminski G, Bar R, Tal D. Ondansetron for the prevention of seasickness in susceptible sailors: an evaluation at sea. Aviat Space Environ Med. 2009;80(7):643-646.

Grøntved A, Brask T, Kambskard J, Hentzer E. Ginger root against seasickness. A controlled trial on the open sea. Acta Otolaryngol. 1988;105(1–2):45-49.

Alkaissi A, Ledin T, Odkvist LM, Kalman S. P6 acupressure increases tolerance to nauseogenic motion stimulation in women at high risk for PONV. Can J Anaesth. 2005;52(7):703-709.

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PHENERGAN 10 MG TABLETS - patient leaflet, side effects, dosage

R06AD02 promethazine

Dostupné balení:

Sources: Original (products.mhra.gov.uk)

Patient leaflet - PHENERGAN 10 MG TABLETS

Phenergan 10 mg

promethazine hydrochloride

Is this leaflet hard to see or read? Phone 0800 035 2525 for help

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

Always take this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you.

Keep this leaflet. You may need to read it again
Ask your pharmacist if you need more information or advice
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4 .
You must talk to a doctor if you do not feel better or if you feel worse after 7 days.

1. What Phenergan Tablets are and what they are used for

2. What you need to know before you take Phenergan Tablets

3. How to take Phenergan Tablets

4. Possible side effects

5. How to store Phenergan Tablets

6. Contents of the pack and other information

What Phenergan Tablets are used for

Phenergan Tablets are used to treat the following conditions:

For short term use: to treat adults with difficulty sleeping (insomnia)
To treat allergic conditions such as hay fever or rashes (like nettle rash or hives)
To treat or stop you feeling sick (nausea) or being sick (vomiting) such as travel sickness
For short term use: as a sedative for

children aged 5 years and above

2. what you need to know before you take phenergan tablets

Qis do not take this medicine if:.

X The person taking the medicine is under

5 years of age

X You are allergic (hypersensitive) to promethazine hydrochloride or any of the other ingredients of Phenergan Tablets (listed in Section 6 below)

X The signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue.

X You are taking a medicine for depression called a monoamine oxidase inhibitor (MAOI). Also do not take Phenergan Tablets if you have stopped taking one of these MAOI medicines within the last 14 days. If you are not sure ask your doctor or pharmacist (see “Taking other medicines” section below)

X The person is unconscious (in a coma) or suffers from severe dizziness, drowsiness or headache

Do not take this medicine if any of the above applies to you. If you are not sure, talk to your doctor or pharmacist before taking Phenergan Tablets.

1. What Phenergan Tablets are and what they are used for

Warnings and precautions

Phenergan Tablets contain a medicine called promethazine hydrochloride. This belongs to a group of medicines called phenothiazines. It works by blocking a natural substance (histamine) that your body makes during an allergic reaction. It also works directly on the brain to help you feel more relaxed.

Check with your doctor or pharmacist

Before taking your medicine if.

You have difficulty breathing, wheezing,

tightness in the chest (asthma) or an

infection in your lungs (bronchitis)

You have epilepsy You have any serious heart problems

11503107–08

A You have liver or kidney problems

A You have a stomach blockage or difficulty passing water (urine)

A You have hearing problems

A You have increased pressure in the eye (narrow angle glaucoma)

A You have had something called Reye’s Syndrome or possible Reye’s Syndrome signs include being sick and confused following a viral illness

If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Phenergan Tablets.

SS.hermed^andPhenerganTab.

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines you can buy without prescription, including herbal medicines. This is because Phenergan Tablets can affect the way some medicines work. Also some medicines can affect the way Phenergan Tablets work.

Do not take this medicine, and tell your doctor, if you are taking or have taken the following in the last 2 weeks:

Some medicines for depression called monoamine oxidase inhibitors (MAOIs). If you are not sure ask your doctor or pharmacist

Tell your doctor or pharmacist if you are taking any of the following:

Anticholinergic medicines – includes some medicines used for irritable bowel syndrome, asthma or weak bladder. These can increase the risk of dizziness, dry mouth and blurred eyesight
Medicines for depression (such as amitriptyline)
Medicines to help you to sleep or feel more relaxed (such as diazepam or zolpidem)
Medicines such as aspirin (for arthritis and pain in your joints). Phenergan Tablets may hide the side effects of these medicines

Phenergan Tablets with food and drink Do not drink alcohol while you are taking Phenergan Tablets. This is because it can affect the way the medicine works.

Pregnancy and breast-feeding

Talk to your doctor or pharmacist before taking this medicine if you are pregnant, might become pregnant, or think you may be pregnant. Phenergan Tablets should not be taken 2 weeks before birth.

You should not take Phenergan Tablets if you are breast-feeding. This is because small amounts may pass into mothers’ milk. This can be harmful to your baby.

If you are breast-feeding or planning to breast-feed, talk to your doctor or pharmacist before taking any medicine.

I Driving and using machines

You may feel drowsy or sleepy after taking this medicine or in the morning after taking this medicine. If this happens, do not drive or use any tools or machines.

Phenergan Tablets contains lactose:

If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

3.How to take Phenergan Tablets

Always use this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

The amount you need to take depends on the reason you are taking Phenergan Tablets. The following information will help you to decide how much you need to take.

Taking this medicine

Take this medicine by mouth
Do not take for longer than 7 days. If your symptoms worsen or do not improve after 7 days talk to your doctor or pharmacist
If you feel the effect of your medicine is too weak or too strong, do not change the dose yourself, but ask your doctor

How much to take

The recommended dose is:

For allergies (such as hay fever, rashes and hives)

Children 2–5 years:

Phenergan Elixir should be given in this age group

Children 5–10 years:

A single dose of either one or two tablets (10mg or 20mg) given at night or one tablet (10mg) given twice a day
DO NOT give more than two tablets (20mg) each day

Children over 10 years and adults (including the elderly):

Start with one tablet (10mg) twice a day
This may be increased to a maximum of two tablets (20mg) three times a day

For treatment and prevention of feeling sick or being sick (such as travel sickness)

A single tablet to be taken the night before the journey
This may be repeated after 6–8 hours if necessary
Two tablets (20mg) to be taken the night before the journey

As a short term paediatric sedative and for short term treatment of insomnia in adults

Two tablets (20mg) given as a single dose at night time

Children over 10 years and adults

(including the elderly):

Two to five tablets (20mg to 50mg) as a single dose at night time

Use this medicine only as recommended. Do not exceed the recommended dose.

Exposure to sunlight

Phenergan Tablets can make your skin more sensitive to sunlight. Keep out of direct sunlight while taking this medicine.

If you take more Phenergan Tablets than you should

If you or your child takes more Phenergan Tablets than you should, tell a doctor or go to a hospital casualty department straight away. Take the medicine pack with you.

This is so the doctor knows what you or your child has taken.

The following effects may happen:

In children: Excitation, moving unsteadily or stumbling, uncontrolled writhing movements especially of the hands or feet, hallucinations, fits (seizures), loss of consciousness, uneven heart beat and breathing difficulties.

In adults: Feeling sleepy or drowsy, fits, loss of consciousness, uneven heart beat and breathing difficulties.

If you forget to take Phenergan Tablets Do not take a double dose to make up for a forgotten dose

If you are taking Phenergan Tablets for an allergic condition – take your medicine as soon as you remember, then carry on as before
If you are taking Phenergan Tablets for sedation or sleeping problems – miss that dose and take the next evening’s dose as usual

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Taking Phenergan Tablets may affect the results of certain tests. These include some pregnancy tests and skin tests. Phenergan Tablets should not be taken at least 3 days before the start of a skin test.

4. possible side effects

Like all medicines, Phenergan Tablets can cause side effects, although not everybody gets them.

Stop taking Phenergan Tablets and see a doctor or go to a hospital straight away if you notice any of the following side effects: An allergic reaction. The signs may include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue
Liver problems that may cause the eyes or skin to go yellow (jaundice)
Muscle stiffness or shaking
Being unable to control some muscles in your head or face
You notice unusual movements of the tongue, facial muscle spasms, rolling eyes and trembling
Very fast, uneven or forceful heartbeat (palpitations)
Irregular heartbeat
Tiredness which lasts for a long time. This may be due to a blood problem called anaemia
Over-active behaviour in children

Tell your doctor or pharmacist if any of the following side effects get serious or lasts longer than a few days. Also tell them if you notice any side effects not listed in this leaflet.

Dry mouth, blurred vision or you cannot pass water (urine)
Feeling drowsy or sleepy, tiredness, disorientation, having nightmares, headaches, feeling restless
Loss of appetite (anorexia), indigestion
Feeling dizzy, lightheaded, faint (hypotension) Feeling confused, especially in elderly people Being more sensitive to the sun than usual.

If this happens keep out of direct sunlight and do not use sun lamps

Unpleasant sensation or an overwhelming urge to move the legs (also called Restless Legs Syndrome).

Reporting of Side Effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at:. gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

By reporting side effects you can help provide more information on the safety of this medicine.

5. how to store phenergan tablets

Keep this medicine out of the sight and reach of children
Do not take Phenergan Tablets after the expiry date which is stated on the carton and blister pack after EXP. The expiry date refers to the last day of that month
Store below 30°C
Store in the original carton in order to protect from light

Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

6. contents of the pack and other information

What phenergan tablets contains..

Each tablet contains 10mg of the active substance, promethazine hydrochloride
The other ingredients are lactose, maize starch, povidone, magnesium stearate, polyethylene glycol, Opaspray (contains titanium dioxide-E171, hypromellose-E464 and indigo carmine aluminium lake blue-E132) and hypromellose

What Phenergan Tablets look like and contents of the pack

A pale blue film coated tablet marked PN 10 on one side. The tablets are available in blister packs of 56.

Marketing Authorisation Holder and Manufacturer

Marketing Authorisation Holder

410 Thames Valley Park Drive Reading

Tel: 0800 035 2525

Manufacturer

FAMAR HEALTH CARE SERVICES MADRID, S.A.U.

Avda. Leganes, 62

Alcorcon 28923

This leaflet does not contain all the information about your medicine. If you have any questions or are not sure about anything, ask your doctor or pharmacist.

This leaflet was last revised in 09/2020

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Consumer medicine information

Promethazine hydrochloride

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BRAND INFORMATION

Active ingredient

Phenergan F/C 10 mg

Phenergan F/C 25 mg

Consumer medicine information (cmi) leaflet.

Please read this leaflet carefully before you start using Phenergan.

Download CMI (PDF)
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Phenergan ® (fen-er-gan)

Active ingredient: Promethazine hydrochloride (PRO-meth-ar-zine HIGH-dro (h)-CLOR-ride)

Consumer Medicine Information (CMI)

This leaflet provides important information about using Phenergan. You should also speak to your doctor or pharmacist if you would like further information or if you have any concerns or questions about using Phenergan.

Where to find information in this leaflet:

1. Why am I using Phenergan? 2. What should I know before I use Phenergan? 3. What if I am taking other medicines? 4. How do I use Phenergan? 5. What should I know while using Phenergan? 6. Are there any side effects? 7. Product details

1. Why am I using Phenergan?

Phenergan contains the active ingredient promethazine hydrochloride.

Phenergan is an antihistamine used to treat a number of conditions:

allergies - allergic contact dermatitis, hives, hayfever, bites and stings
respiratory symptoms due to allergies - runny nose
nausea and vomiting - motion sickness
assists in the management of the symptoms of chicken pox and measles by acting as a sedative
for short-term use for sedation on the advice of a pharmacist or doctor - do not use for more than 7-10 days

Antihistamines help reduce allergic symptoms by preventing the effects of a substance called histamine. Histamine is produced by the body in response to foreign substances that the body is allergic to.

Your pharmacist or doctor may have recommended Phenergan for another reason.

Ask your pharmacist or doctor if you have any questions about this medicine.

2. What should I know before I use Phenergan?

Phenergan must not be used in children under 2 years of age, due to the potential for fatal respiratory depression.

Do not use Phenergan if:

you are allergic to promethazine hydrochloride, medicines of similar properties or belonging to the specific family of chemicals called phenothiazines, other phenothiazines, or any of the ingredients listed at the end of this leaflet. Always check the ingredients to make sure you can use this medicine. Some of the symptoms of an allergic reaction may include: - shortness of breath - wheezing or difficulty breathing - swelling of the face, lips, tongue or other parts of the body - rash, itching or hives on the skin If you take this medicine after the expiry date has passed, it may not work as well.
the packaging is torn or shows signs of tampering.

Any person who is unconscious or in a coma must not be treated with Phenergan.

Do not give Phenergan to newborn or premature babies.

Check with your doctor or pharmacist if you:

have allergies to: - any other medicines - any other substances, such as foods, preservatives or dyes
have or have had any medical conditions, especially the following: - kidney or liver disease - parkinson's disease - underactive thyroid gland (hypothyroidism) - tumour growing in adrenal glands (pheochromocytoma) - autoimmune disorder (myasthenia gravis) - epilepsy - cardiovascular disease/cardiac failure - blood pressure problems - low white blood cell count (agranulocytosis) - bladder problems - breathing problems - glaucoma - an eye condition - prostate problems - stomach ulcer or blockage
develop a fever or an infection to confirm if laboratory tests are required to check your blood count
plan to have surgery
take sedatives
take any medicines for any other condition
have any personal or family history of heart disease
have an irregular heartbeat

If you experience an allergic reaction, seek medical help right away.

Caution must be exercised when using Phenergan due to the risk of sedation.

If you experience fever, sore throat or any other infection, you should inform your doctor or pharmacist immediately and undergo a complete blood count. Treatment should be discontinued if any marked changed are observed in the blood count.

During treatment, you may be at risk of developing certain side effects. It is important you understand these risks and how to monitor for them. See additional information under Section 6. Are there any side effects?

Pregnancy and breastfeeding

Check with your doctor or pharmacist if you are a woman of childbearing age and not using effective contraception. Check with your doctor or pharmacist if you are pregnant, might become pregnant or think you may be pregnant.

Do not take Phenergan if you are pregnant or plan to become pregnant.

It may affect your developing baby if you take it during pregnancy. If there is a need to consider Phenergan during your pregnancy, Your pharmacist or doctor will discuss the benefits and possible risks of taking the medicine during pregnancy.

Talk to your doctor or pharmacist if you are breastfeeding or intend to breastfeed.

Do not take Phenergan if you are breastfeeding or plan to breastfeed.

It passes into the breast milk and there is a possibility that the baby may be affected.

Use in Children

Because of the risk of chocking, the tablets should be avoided in children who have difficulty swallowing tablets.

3. What if I am taking other medicines?

Tell your doctor or pharmacist if you are taking any other medicines, including any medicines, vitamins or supplements that you buy without a prescription from your pharmacy, supermarket or health food shop.

Some medicines may interfere with Phenergan and affect how it works

Phenergan may increase the sedative effect of some medicines. These include:

medicines used to treat depression, especially monoamine oxidase inhibitors and tricyclic antidepressants
medicines used to help you sleep or relax (sedatives and hypnotics)
opioid analgesics, medicines used to treat pain
other antihistamines
alcohol and alcohol containing medicines
medicines for the treatment of irregular heartbeats (antiarrhythmics)
medicines that help with your mood (antidepressants)
medicines used to help with mental illness (antipsychotics)
medicines to treat infections (antimicrobials)
medicines used to treat nausea and vomiting like metoclopramide
medicines used to relieve muscle spasm like carisoprodol and cyclobenzaprine
medicines used for the treatment of epilepsy or seizures
medicines used to treat acid indigestion such as magnesium, aluminium and calcium salts, oxides and hydroxides
medicines used to smooth muscle contractions in the gastrointestinal tract (antispasmodics)

These medicines may be affected by Phenergan or may affect how well it works. You may need different amounts of your medicines, or you may need to take different medicines.

Check with your doctor or pharmacist if you are not sure about what medicines, vitamins or supplements you are taking and if these affect Phenergan.

4. How do I use Phenergan?

How much to take.

Follow the instructions provided with the medicine. If you do not understand the instructions on the carton or the label, ask your pharmacist or doctor for help.
Follow all directions given to you by your pharmacist or doctor carefully. They may differ from the information contained in this leaflet.
Use this drug only as recommended.
Do not exceed the recommended dosage. There have been case reports of promethazine abuse.
Phenergan tablets are recommended for adults and children over 6 years of age.
Phenergan elixir is recommended for children 2-5 years of age.
It is recommended that the lowest effective dose of Phenergan be used in children 2 years of age or older.

Allergic Disorder

Adults: One to three 25mg tablets as a single dose at night, or one to two 10mg tablets, two to three times daily.
Children 6-12 years: One to two 10mg tablets, or 10 to 25mL of the elixir as a single dose at night, or one 10mg tablet, or 10mL of the elixir, two to three times daily.
Children 2-5 years: 5-15mL of elixir as a single dose at night, or 5mL of elixir, two to three times daily.
For short term use on the advice of a pharmacist or doctor.
Adults: One to three 25mg tablets as a single dose at night.
Children 6-12 years: One to two 10mg tablets, or 10 to 25mL of the elixir, as a single dose at night.
Children 2-5 years: 5-15mL of elixir as a single dose at night.

Travel Sickness

Adults: One 25mg tablet.
Children 6-12 years: One 10mg tablet or 10mL of the elixir.
Children 2-5 years: 5mL of elixir.
To be taken the night before travel and repeated after 6 to 8 hours on the following day if required.

Nausea and Vomiting

Adults: One 25mg tablet every 4 to 6 hours to a maximum daily dose of four 25mg tablets.
Children 6-12 years: One 10mg tablet or 10mL of the elixir, every 4 to 6 hours to a maximum daily dose of two 10mg tablets or 25mL of the elixir.
Children 2-5 years: 5mL of elixir every 4 to 6 hours to a maximum daily dose of 15mL.

Use in the Elderly

If you are over 65 years of age, talk to you pharmacist or doctor about how much to take.
Elderly patients are more likely to have side effects from taking these medicines.

How to take Phenergan

Swallow Phenergan tablets whole with a full glass of water.
Measure out the amount of elixir to be taken.

How long to take it

Phenergan should not usually be taken for more than 10 days in a row. If your symptoms persist, see your pharmacist or doctor for advice.

If you forget to take it

If you are taking Phenergan for an allergic disorder and you forget to take your bedtime dose, you may need to take your dose in two or three smaller doses during the following day. Check with your pharmacist or doctor.

If you are taking Phenergan for travel sickness or nausea and vomiting, take your dose as soon as you remember.

If you are taking Phenergan for sedation, take your dose as soon as you remember. Be careful because you may still be affected in the morning.

Do not take a double dose to make up for the dose that you missed. This may be harmful.

If you are not sure what to do, ask your pharmacist or doctor.

If you have trouble remembering to take your medicine, ask your pharmacist for some hints.

If you use too much Phenergan (overdose)

If you think that you have used too much Phenergan, you may need urgent medical attention.

You should immediately:

phone the Poisons Information Centre ( by calling 13 11 26 in Australia or 0800 764 766 in New Zealand ), or
contact your doctor, or
go to the Emergency Department at your nearest hospital.

You should do this even if there are no signs of discomfort or poisoning.

If you take too much Phenergan, you may experience:

convulsions and/or tremors
difficulty breathing
unconsciousness
acute anxiety
hallucinations
heart palpitations, chest pain and/or rapid pulse
cold sweats
over - excitement
shaky and unsteady movements

5. What should I know while using Phenergan?

Things you should do.

Remind any doctor, dentist or pharmacist you visit that you are using Phenergan.

Phenergan may cause your skin to be more sensitive to the sun. You should protect your skin from exposure to bright sunlight.

If you are about to be started on any new medicine, tell your pharmacist or doctor that you are taking Phenergan.

If you plan to have surgery that needs a general anaesthetic, tell your doctor or dentist that you are taking this medicine.

If you become pregnant while you are taking this medicine, stop taking it and tell your doctor immediately.

Talk to your pharmacist or doctor if your symptoms do not improve.

Your pharmacist or doctor will assess your condition and decide if you should continue to take the medicine.

Things you should not do

Do not give Phenergan to anyone else, even if they have the same condition as you.
Do not take Phenergan to treat any other complaints unless your pharmacist or doctor tells you to.
Do not take more than the recommended dose unless your pharmacist or doctor tells you to.

Things to be careful of

Phenergan is a known sedative and may cause drowsiness in some people.
If you have a single dose at bedtime, you may still be affected in the morning.
Children and the elderly are especially sensitive to the effects of antihistamines.

Neuroleptic malignant syndrome

A very serious and sometimes deadly health problem called neuroleptic malignant syndrome (NMS) may happen. Stop treatment and call your doctor right away if you have high fever, muscle cramps or stiffness, dizziness, very bad headache, fast heartbeat, confusion, agitation, hallucinations, or are sweating a lot.

Driving or using machines

Phenergan can cause drowsiness, dizziness and blurred vision. Make sure you know how you react to Phenergan before you drive a car, operate machinery, or do anything else that could be dangerous if you experience drowsiness, dizziness and blurred vision. If this occurs do not drive or operate machinery.

Be careful before you drive or use any machines or tools until you know how Phenergan affects you.

Phenergan may affect your ability to drive a car or operate machinery or do anything else that could be dangerous if you are drowsy, dizzy or experience blurred vision. If this occurs do not drive or operate machinery.

Drinking alcohol

Tell your doctor or pharmacist if you drink alcohol.

Do not drink alcohol while taking Phenergan.

The sedation effects of alcohol may be increased.

Looking after your medicine

Keep your medicine in the pack until it is time to take it.
If you take your medicine out of the pack it will not keep as well.
Store Phenergan tablets below 30°C.
Store Phenergan elixir below 25°C.

Follow the instructions in the carton on how to take care of your medicine properly.

Store it in a cool dry place away from moisture, heat or sunlight; for example, do not store it:

in the bathroom or near a sink, or
in the car or on window sills.

Keep it where young children cannot reach it, in a locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines

Getting rid of any unwanted medicine

If you no longer need to use this medicine or it is out of date, take it to any pharmacy for safe disposal.

Do not use this medicine after the expiry date.

6. Are there any side effects?

All medicines can have side effects. If you do experience any side effects, most of them are minor and temporary. However, some side effects may need medical attention.

See the information below and, if you need to, ask your doctor or pharmacist if you have any further questions.

Less serious side effects

These are mild side effects of the medicine and are short-lived.

Serious/rare side effects

The above list includes serious side effects that may require medical attention. Serious side effects are rare.

The above list includes very serious side effects. You may need urgent medical attention or hospitalisation. These side effects are very rare.

Tell your doctor or pharmacist if you notice anything else that may be making you feel unwell.

Other side effects not listed here may occur in some people.

Reporting side effects

After you have received medical advice for any side effects you experience, you can report side effects to the Therapeutic Goods Administration online at www.tga.gov.au/reporting-problems or Medsafe in New Zealand www.medsafe.govt.nz/safety/report-a-problem.asp#Medicine . By reporting side effects, you can help provide more information on the safety of this medicine.

7. Product details

This medicine is available over-the-counter without a doctor's prescription.

What Phenergan Tablets contain

Do not take this medicine if you are allergic to any of these ingredients.

What Phenergan Elixir contains

What phenergan looks like.

Phenergan Tablets are available in two strengths:

10mg - circular, film-coated biconvex tablets with bevelled edges, pale blue in colour, one face impressed 'PN' above ‘10', the reverse face plain.
25mg - circular, film-coated biconvex tablets with bevelled edges, pale blue in colour, one face impressed 'PN' above '25', the reverse face plain.

Both tablet strengths are available in blister packs of 50 tablets and 25 tablets (New Zealand only).

Phenergan Elixir is a clear, bright, golden, syrupy liquid. Phenergan elixir is available in a 100mL bottle

Australian Registration Numbers

Phenergan 10mg tablets AUST R 80159

Phenergan 25mg tablets AUST R 80160

Phenergan Elixir 1mg/mL AUST R 61576

Who distributes Phenergan

Phenergan Tablets and Elixir are supplied in Australia by:

Sanofi Consumer Healthcare 87 Yarraman Place Virginia Australia Toll Free Number (medical information) 1800 818 806

This leaflet was prepared in May 2022.

phenergan-ccdsv45cmiv13-27may22

Published by MIMS July 2022

1 Name of Medicine

Promethazine hydrochloride.

2 Qualitative and Quantitative Composition

Excipients with known effect., 3 pharmaceutical form, 4 clinical particulars, 4.1 therapeutic indications, upper respiratory tract., nausea and vomiting., 4.2 dose and method of administration, children 6-12 years., children 2-5 years., 4.3 contraindications.

Promethazine is contraindicated for use in patients with a history of hypersensitivity to the drug substance, substances of similar chemical structure, other phenothiazines or hypersensitivity to the other ingredients in the formulation. Phenergan sugar free (orange flavour) elixir should not be given to patients with allergies to sodium metabisulfite, sodium sulfite or sodium benzoate. Promethazine is contraindicated for use in: children under 2 years of age because of the potential for fatal respiratory depression. Post-marketing cases of respiratory depression, including fatalities, have been reported with the use of promethazine in paediatric patients less than 2 years of age. A wide range of weight-based doses of Phenergan have resulted in respiratory depression in these patients (see Section 4.4 Special Warnings and Precautions for Use); lactating women; patients taking monoamine oxidase inhibitors (MAOIs) up to 14 days previously (see Section 4.5 Interactions with Other Medicines and Other Forms of Interactions); jaundice induced by other phenothiazine derivatives; patients in coma or suffering from CNS depression of any cause or who have received high doses of other CNS depressants. See Section 4.5 Interactions with Other Medicines and Other Forms of Interactions for additional information.

4.4 Special Warnings and Precautions for Use

Hypertensive crisis., use in hepatic impairment., use in renal impairment., use in the elderly., paediatric use., effects on laboratory tests., 4.5 interactions with other medicines and other forms of interactions, cytochrome p450 2d6 metabolism., seizure threshold-lowering drugs., gastro-intestinal agents that are not absorbed (magnesium, aluminium and calcium salts, oxides and hydroxides)., drugs with anticholinergic properties., 4.6 fertility, pregnancy and lactation, effects on fertility., 4.7 effects on ability to drive and use machines.

Promethazine considerably affects the ability to drive a vehicle and operate machines. Promethazine may cause drowsiness, dizziness and blurred vision and can considerably affect the ability of driving a vehicle and operating machines. Drowsiness may continue the following day. Those affected should not drive or operate machinery.

4.8 Adverse Effects (Undesirable Effects)

Cns effects., anticholinergic effects., more common reactions., gastrointestinal disorders., nervous system disorders., eye disorders., less common reactions., cardiovascular., skin and subcutaneous tissue disorders., haematological., respiratory., reactions with frequency unknown., hepatobiliary disorders., renal and urinary disorders., immune system disorders., metabolism and nutrition disorders., blood and lymphatic system disorders., psychiatric disorders., cardiac disorders., respiratory, thoracic and mediastinal disorders., vascular disorders., general disorders and administration site conditions., severe or life threatening reactions., reporting suspected adverse effects., 4.9 overdose, 5 pharmacological properties, 5.1 pharmacodynamic properties, mechanism of action., clinical trials., 5.2 pharmacokinetic properties, absorption., distribution., metabolism., 5.3 preclinical safety data, genotoxicity., carcinogenicity., 6 pharmaceutical particulars, 6.1 list of excipients.

Phenergan Elixir contains sodium benzoate, sodium sulfite, sodium metabisulfite, maltitol solution, acesulfame potassium, sodium citrate dihydrate, citric acid monohydrate, ascorbic acid, caramel, purified water and orange juice flavour 510844E. Phenergan Tablets contain lactose monohydrate, maize starch, povidone, magnesium stearate, hypromellose, macrogol 200 and opaspray blue M-1-4210A.

6.2 Incompatibilities

Incompatibilities were either not assessed or not identified as part of the registration of this medicine.

6.3 Shelf Life

In Australia, information on the shelf life can be found on the public summary of the Australian Register of Therapeutic Goods (ARTG). The expiry date can be found on the packaging.

6.4 Special Precautions for Storage

6.5 nature and contents of container, 6.6 special precautions for disposal.

In Australia, any unused medicine or waste material should be disposed of by taking to your local pharmacy.

6.7 Physicochemical Properties

Chemical structure., cas number., 7 medicine schedule (poisons standard).

Elixir, Tablets: Pharmacist Only Medicine (Schedule 3).

Summary Table of Changes

Date published: 01 july 2022.

Reasonable care is taken to provide accurate information at the time of creation. This information is not intended as a substitute for medical advice and should not be exclusively relied on to manage or diagnose a medical condition. NPS MedicineWise disclaims all liability (including for negligence) for any loss, damage or injury resulting from reliance on or use of this information. Read our full disclaimer . This website uses cookies. Read our privacy policy .

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Promethazine hydrochloride oral

Pregnancy and lactation.

PHENERGAN 10mg tablets
PHENERGAN 25mg tablets
PHENERGAN 5mg/5ml elixir
PHENERGAN NIGHTIME 25mg tablets
promethazine hydrochloride 10mg tablets
promethazine hydrochloride 20mg tablets
promethazine hydrochloride 25mg tablets
promethazine hydrochloride 5mg/5ml oral solution sugar-free
SOMINEX 20mg tablets

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Hypersensitivity reactions

Prevention of motion sickness.

Children 10 to 18 years

Children 5 to 10 years

Children 2 to 5 years

Use promethazine hydrochloride with caution during pregnancy. Promethazine hydrochloride is contraindicated in the 2 weeks prior to delivery.

The manufacturer recommends promethazine hydrochloride is not used during pregnancy unless the potential benefit to the mother outweighs the potential risk to the foetus. However, the manufacturer also recommends that the medication is not used in the 2 weeks prior to delivery as there is a risk of irritability and excitement in the neonate.

Use promethazine hydrochloride with caution during breastfeeding.

The manufacture advises that the amount excreted in breast milk is insignificant. However, there is a risk of neonatal irritability and excitement.

Presentation

Oral formulations of promethazine hydrochloride.

Not all available brands are licensed for all indications.

Individual brands may vary in their dosage recommendations and maximum daily dosage.

Insomnia 20mg to 50mg at night.

Hypersensitivity reactions 10mg twice a day increasing to a maximum of 20mg three times daily as required or 25mg as a single dose increasing to a maximum of 25mg twice daily as required.

Prevention of motion sickness 20mg to 25mg to be taken the night before the journey. To be repeated after 6 to 8 hours as required.

Sedative 20 to 25mg as a single night time dose.

Hypersensitivity reactions Either 10 to 25mg as a single dose (best taken at night) or 5 to 10mg twice a day. Maximum daily dose 25mg.

Prevention of motion sickness 10mg to be taken the night before the journey. To be repeated after 6 to 8 hours as required.

Children 2 to 5 years The use of promethazine hydrochloride oral solution is recommended for this age group.

Sedative 15 to 20mg as a single night time dose.

Hypersensitivity reactions 5mg to 15mg as a single dose (best taken at night) or 5mg twice a day. Maximum daily dose 15mg.

Prevention of motion sickness 5mg to be taken the night before the journey. To be repeated after 6-8 hours as required.

It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

The following number will direct the caller to the relevant local centre (0844) 892 0111

Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).

Further Information

Last Full Review Date: December 2019

Reference Sources

Summary of Product Characteristics: Phenergan 10mg Tablets. Aventis Pharma Limited, trading as Sanofi. Revised October 2019.

Summary of Product Characteristics: Phenergan 25mg Tablets. Aventis Pharma Limited, trading as Sanofi. Revised October 2019.

Summary of Product Characteristics: Phenergan Night Time 25mg Tablets. Aventis Pharma Limited, trading as Sanofi. Revised October 2019.

Summary of Product Characteristics: Phenergan Elixir. Aventis Pharma Limited, trading as Sanofi. Revised October 2019.

Summary of Product Characteristics: Sominex Tablets. Teva UK Limited. Revised March 2018.

FDB Disclaimer:

IMPORTANT NOTICE:

First Databank UK Ltd is proud of the extensive editorial and quality control procedures which it has developed over many years. However, since every patient's history is different, and even the most exhaustive sources of information cannot cover every possible eventuality, you should be aware that all information is provided from FDB Multilex on the basis that the healthcare professionals responsible for patient care will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for all patients and, in particular whether the use of any drug or other products is safe, appropriate or effective for any particular patient or in any particular circumstances. This is because (and all healthcare professionals should bear in mind):

FDB Multilex are intended to supplement, not substitute for, the expertise and judgment of physicians, pharmacists or other healthcare professionals and should not be taken as an indication of suitability of a particular treatment for a particular individual.
FDB Multilex and those who are responsible for their construction, operation and maintenance do not know the particular circumstances, condition or medical history of particular patients or groups of patients and so cannot advise as to particular cases.
While FDB Multilex use reputable sources of information, such as published data of pharmaceutical manufacturers, it does not validate or verify the information received from third parties.
The information stored on FDB Multilex is not exhaustive. It therefore cannot be relied upon as complete.
Although the information stored on FDB Multilex is updated on a regular basis, healthcare professionals should ensure that they are satisfied that the information they have is current.

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COMMENTS

Phenergan (Promethazine): Medication against travel sickness
2024. The unpleasant symptoms of travel sickness (aeroplane, ship, car or bus) can be prevented by a drug called Phenergan. Its active ingredient is called Promethazine. It is an antihistamine that helps to prevent the effects of histamine in the body, helping you to avoid many unpleasant symptoms associated with travelling.
Phenergan Uses, Dosage & Side Effects
very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out. Side effects such as confusion and severe drowsiness may be more likely in older adults. Common Phenergan side effects may include: drowsiness, dizziness; ringing in your ears; double vision;
Phenergan Dosage Guide
The average adult dose is 25 mg taken twice daily. The initial dose should be taken one-half to one hour before anticipated travel and be repeated 8 to 12 hours later, if necessary. On succeeding days of travel, it is recommended that 25 mg be given on arising and again before the evening meal. For children, Phenergan Tablets, Syrup, or Rectal ...
Promethazine (Oral Route) Proper Use
The dose is usually 6.25 to 12.5 mg three times a day; or 25 mg at bedtime as needed. Children younger than 2 years of age—Use and dose must be determined by your doctor . For prevention of motion sickness: Adults and teenagers—25 mg twice daily; this initial dose should be taken one-half to one hour before traveling.
Phenergan Oral: Uses, Side Effects, Interactions, Pictures ...
For motion sickness, the first dose of promethazine should be taken 30 to 60 minutes before beginning travel. For allergies , this medication may be taken once daily at bedtime to avoid being ...
Phenergan: 7 things you should know
When taking Phenergan to aid sleep, administer it just before bedtime. When used to prevent motion sickness, administer 30 minutes to one hour before travel. Do not use in children under the age of 2 years as several cases of respiratory depression (marked slow-down in breathing) have been reported, some fatal.
Phenergan, Promethegan (promethazine) dosing, indications, interactions
Motion Sickness. 25 mg PO/PR 30-60 minutes before departure and q8-12hr PRN; on succeeding travel days, 25 mg PO/PR every morning and every evening. ... 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses . 100 mgdeutetrabenazine. promethazine and deutetrabenazine both increase sedation.
Promethazine hydrochloride
Available as. Tablets, oral liquid medicine and injection. Promethazine belongs to a group of medicines known as sedating antihistamines. It has several uses. It is used to prevent (or treat) feelings of sickness (nausea). It is commonly recommended for sickness associated with travel and for vertigo.
Phenergan 10mg Tablets
Phenergan Tablets are used to treat the following conditions: To treat allergic conditions such as hay fever or rashes (like nettle rash or hives). To treat or stop you feeling sick (nausea) or being sick (vomiting) such as travel sickness. For short term use: to treat adults with difficulty sleeping (insomnia).
Phenergan (Promethazine): Side Effects, Uses, Dosage ...
The administration of promethazine hydrochloride in 25- mg doses will control minor transfusion reactions of an allergic nature. Motion Sickness. The average adult dose is 25 mg taken twice daily. The initial dose should be taken one-half to one hour before anticipated travel and be repeated 8 to 12 hours later, if necessary.
Promethazine: drowsy (sedating) antihistamine that relieves ...
Dosage and strength. Promethazine comes in 10mg, 20mg and 25mg tablets. Your dose depends on why you're taking it: short-term insomnia - you'll usually take 20mg to 50mg at night; hay fever - you'll usually take from 10mg twice a day to 20mg, 3 times a day; hives - you'll usually take from 10mg twice a day to 20mg 3 times a day; preventing motion sickness - you'll usually take 25mg 1 ...
PDF Phenergan (fen-er-gan)
Travel Sickness • Adults: One 25mg tablet. • Children 6-12 years: One 10mg tablet or 10mL of the elixir. • Children 2-5 years: 5mL of elixir. • To be taken the night before travel and repeated after 6 to 8 hours on the following day if required. Nausea and Vomiting • Adults: One 25mg tablet every 4 to 6 hours to a
Prevention and Treatment of Motion Sickness
To prevent and reduce symptoms of motion sickness, passengers should look forward at a fixed point on the horizon and avoid close visual tasks. C. 2 - 5. To prevent and reduce symptoms of motion ...
Promethazine Dosage Guide for Adults
The average promethazine dosage for adults with motion sickness is 25 mg two times daily. You'll take the first dose of promethazine 30 to 60 minutes before travel. Then repeat the dose 8 to 12 hours later if necessary. After that, it's sometimes recommended to take 25 mg in the morning and before the evening meal on each additional day of ...
PHENERGAN 10 MG TABLETS
11503107-08. How much to take. The recommended dose is: For allergies (such as hay fever, rashes and hives) Children 2-5 years: Phenergan Elixir should be given in this age group. Children 5-10 years: A single dose of either one or two tablets (10mg or 20mg) given at night or one tablet (10mg) given twice a day.
Phenergan
10 to 25 mg as a single dose at night, or 10 mg two to three times daily. Sedation. Adults. 25 to 75 mg as a single dose at night. Children 6-12 years. 10 to 25 mg as a single dose at night. Travel sickness. Adults. 25 mg. Children 6-12 years. 10 mg. To be taken the night before travel and repeated after 6 to 8 hours on the following day if ...
PDF PHENERGAN 25mg TABLETS / PROMETHAZINE HYDROCHLORIDE 25mg TABLETS
For treatment and prevention of feeling sick or being sick (such as travel sickness) ... Children 5-10 years: • Phenergan Elixir or Phenergan 10mg Tablets should be given in this age group . Children over 10 years and adults (including the elderly): • A single tablet (25 mg) to be taken the night before the journey
CL0134 P PIL CL6-v0
Promethazine is used to treat the following conditions: to treat allergic conditions, such as hay fever or rashes (like nettle rash or hives). to treat or prevent you feeling sick (nausea) or being sick (vomiting), such as in travel sickness. for short term use: to treat adults with difficulty sleeping (insomnia).
Promethazine hydrochloride oral
Children 10 to 18 years. Insomnia 20mg to 50mg at night.. Hypersensitivity reactions 10mg twice a day increasing to a maximum of 20mg three times daily as required or 25mg as a single dose increasing to a maximum of 25mg twice daily as required.. Prevention of motion sickness 20mg to 25mg to be taken the night before the journey. To be repeated after 6 to 8 hours as required.
Phenergan Drug / Medicine Information
Travel Sickness. Adults: One 25mg tablet. Children 6-12 years: One 10mg tablet or 10mL of the elixir. ... Phenergan 10mg tablets. AUST R 80159. Phenergan 25mg tablets. AUST R 80160.
PROMETHAZINE HYDROCHLORIDE 25 MG TABLETS Adults (including the elderly
sick (such as travel sickness) Adults (including the elderly) and children over 10 years: A single tablet (25 mg) taken the night before the journey. This may be repeated after 6 to 8 hours if necessary. Children 5-10 years: A liquid form of this medicine or Promethazine 10 mg tablets should be used.
PDF PROMETHAZINE HYDROCHLORIDE 10 MG TABLETS
As a short term paediatric sedative and for short term treatment of insomnia in adults. Children 2-5 years: A liquid form of this medicine should be used in this age group. Children 5-10 years: Two tablets (20 mg) given as a single dose at night time. Children over 10 years and adults (including the elderly): Two to five tablets (20 mg to 50 mg ...
Phenergan 10mg Tablets (56)
Key Features: Contains 10mg of the active ingredient. Reliable relief for various conditions. Convenient pack of 56 tablets. Whether you're dealing with allergies, nausea, or other related symptoms, Phenergan tablets are formulated to provide the relief you need. Consult with your healthcare professional for proper usage instructions.

Phenergan (Promethazine) against motion sickness and nausea

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Promethazine

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Next review due: 17 Mar 2026

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Promethazine (Phenergan) - Other brand names: Avomine, Sominex

1. About promethazine

2. Key facts

3. Who can and cannot take promethazine

4. How and when to take promethazine

Dosage and strength

Promethazine mixed with other medicines

How to take it

How to take tablets and capsules

How to take liquid

What if I forget to take it?

What if I take too much?

Urgent advice: Contact 111 for advice if:

5. Side effects

Serious side effects

Serious allergic reaction

Immediate action required: Call 999 now if:

6. How to cope with side effects of promethazine

7. Pregnancy and breastfeeding

Promethazine and breastfeeding

Non-urgent advice: Tell your doctor if you're:

8. Cautions with other medicines

Mixing promethazine with herbal remedies and supplements

Important: Medicine safety

9. Common questions about promethazine

Tips for when you're outside

Tips for when you're inside

Related conditions

Useful resources

Clinical Presentation

Behavioral Interventions

MINIMIZE VESTIBULAR MOTION

HABITUATE TO MOTION

SYNCHRONIZE THE VISUAL SYSTEM WITH THE MOTION

ACTIVELY SYNCHRONIZE THE BODY WITH THE MOTION

REDUCE OTHER SOURCES OF PHYSICAL, MENTAL, AND EMOTIONAL DISCOMFORT

Medications

SCOPOLAMINE

ANTIHISTAMINES

OTHER MEDICATIONS

COMPLEMENTARY AND ALTERNATIVE THERAPIES

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PHENERGAN 10 MG TABLETS - patient leaflet, side effects, dosage

Table of contents

Patient leaflet - PHENERGAN 10 MG TABLETS

promethazine hydrochloride

What Phenergan Tablets are used for

2. what you need to know before you take phenergan tablets

1. What Phenergan Tablets are and what they are used for

Check with your doctor or pharmacist

Pregnancy and breast-feeding

Phenergan Tablets contains lactose: