travel sickness tablets safe in pregnancy

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Does pregnancy make me prone to motion sickness?

Yes, you're more likely to suffer from motion sickness when you're pregnant. But if you're experiencing nausea and vomiting now and it's never been a problem before, it could just as easily be morning sickness, particularly if it's early in your pregnancy. With similar symptoms, the two are very difficult to tell apart.

Interestingly, if you suffered from motion sickness before becoming pregnant, you're more likely to experience morning sickness during pregnancy. If you've started feeling nauseated a lot of the time, but vomit only when you travel , you may have a combination of the two.

Motion sickness is a relatively common problem encountered when people travel by car, by airplane, and particularly by boat. It occurs when your body's balance-sensing system – which includes your inner ear, your eyes, and the sensory nerves in your skin, muscles, and joints – sends conflicting messages to the brain. If your inner ear senses motion, for instance, but your eyes don't, the result is a queasy feeling that may have you reaching for an airsickness bag.

To help ward off motion sickness in a car, sit in the front seat, open the window for fresh air, and focus on the horizon or a distant object. In an airplane, ask for a seat over the wing, where the ride will be smoothest. On a boat, stay on deck and gaze at the horizon.

Frequent light, non-greasy snacks may help soothe a queasy stomach, and it's probably best to avoid having a large, heavy meal just before traveling.

Though research is scant and results are conflicting, some women say that wearing an acupressure wristband helps with motion sickness as well as morning sickness.

Can I take medications for motion sickness during pregnancy?

To get relief from motion sickness, you can use over-the-counter drugs that contain dimenhydrinate (Dramamine) or diphenhydramine ( Benadryl ). These are low-risk for pregnant women, though it's always wise to check with your doctor or midwife before taking any medications during pregnancy .

Although Benadryl is best known as an antihistamine taken for allergies , it's also used to reduce nausea. Because both Dramamine and Benadryl can make you drowsy, don't take either medication if you're driving.

Don't combine Dramamine and Benadryl – take one or the other, because taking them together could compound your drowsiness.

Also, if you're already taking prescription Bonjesta or Diclegis (vitamin B6 and doxylamine) for morning sickness, don't add Dramamine or Benadryl to your regimen.

Talk to your provider before using the prescription drug scopolamine (Scopace) during pregnancy. It's not dangerous for your baby, but your response to it can be different while you're pregnant. It can cause side effects such as dry mouth, dizziness, and fatigue.

Keep in mind that few studies test drugs in pregnant women, which means there's not enough data to completely rule out risk, even for over-the-counter medications. That's why it's important to check with your healthcare provider before taking any medicines while pregnant.

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BabyCenter's editorial team is committed to providing the most helpful and trustworthy pregnancy and parenting information in the world. When creating and updating content, we rely on credible sources: respected health organizations, professional groups of doctors and other experts, and published studies in peer-reviewed journals. We believe you should always know the source of the information you're seeing. Learn more about our editorial and medical review policies .

Briggs GG. 2011. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. 9th ed. Philadelphia, PA: Lippincott Williams and Wilkins.

Mother to Baby. 2021. Diphenhydramine. https://mothertobaby.org/fact-sheets/diphenhydramine-pregnancy/pdf/ Opens a new window [Accessed October 2021]

Mother to Baby. 2021. Meclizine. https://mothertobaby.org/fact-sheets/meclizine-pregnancy/ Opens a new window [Accessed October 2021]

Quinlan J, et al. 2003. Nausea and Vomiting of Pregnancy. American Family Physician. https://www.aafp.org/afp/2003/0701/p121.html Opens a new window [Accessed October 2021]

Mayo Clinic. 2021. Scopolamine. https://www.mayoclinic.org/drugs-supplements/scopolamine-transdermal-route/precautions/drg-20072848 Opens a new window [Accessed October 2021]

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Pregnant Travelers

Pregnant travelers can generally travel safely with appropriate preparation. But they should avoid some destinations, including those with risk of Zika and malaria. Learn more about traveling during pregnancy and steps you can take to keep you and your baby healthy.

Before Travel

Before you book a cruise or air travel, check the airlines or cruise operator policies for pregnant women. Some airlines will let you fly until 36 weeks, but others may have an earlier cutoff. Cruises may not allow you to travel after 24–28 weeks of pregnancy, and you may need to have a note from your doctor stating you are fit to travel.

Zika and Malaria

Zika can cause severe birth defects. The Zika virus is spread through mosquito bites and sex. If you are pregnant, do not travel to  areas with risk of Zika . If you must travel to an area with Zika, use  insect repellent  and take other steps to avoid bug bites. If you have a sex partner who lives in or has traveled to an area with Zika, you should use condoms for the rest of your pregnancy.

Pregnant travelers should avoid travel to areas with malaria, as it can be more severe in pregnant women. Malaria increases the risk for serious pregnancy problems, including premature birth, miscarriage, and stillbirth. If you must travel to an area with malaria, talk to your doctor about taking malaria prevention medicine. Malaria is spread by mosquitoes, so use  insect repellent and take other steps to avoid bug bites.

Make an appointment with your healthcare provider or a travel health specialist  that takes place at least one month before you leave. They can help you get destination-specific vaccines, medicines, and information. Discussing your health concerns, itinerary, and planned activities with your provider allows them to give more specific advice and recommendations.

Plan for the unexpected. It is important to plan for unexpected events as much as possible. Doing so can help you get quality health care or avoid being stranded at a destination. A few steps you can take to plan for unexpected events are to  get travel insurance ,    learn where to get health care during travel ,  pack a travel health kit ,  and  enroll in the Department of State’s STEP .

Be sure your healthcare policy covers pregnancy and neonatal complications while overseas. If it doesn’t get travel health insurance that covers those items. Consider getting medical evacuation insurance too.

Recognize signs and symptoms that require immediate medical attention, including pelvic or abdominal pain, bleeding, contractions, symptoms of preeclampsia (unusual swelling, severe headaches, nausea and vomiting, and vision changes), and dehydration.

Prepare a  travel health kit . Pregnant travelers may want to include in your kit prescription medications, hemorrhoid cream, antiemetic drugs, antacids, prenatal vitamins, medication for vaginitis or yeast infection, and support hose, in addition to the items recommended for all travelers.

During Travel

Your feet may become swollen on a long flight, so wear comfortable shoes and loose clothing and try to walk around every hour or so. Sitting for a long time, like on long flight, increases your chances of getting blood clots, or deep vein thrombosis. Pregnant women are also more likely to get blood clots. To reduce your risk of a blood clot, your doctor may recommend compression stockings or leg exercises you can do in your seat. Also, see CDC’s Blood Clots During Travel page for more tips on how to avoid blood clots during travel.

Choose safe food and drink. Contaminated food or drinks can cause travelers’ diarrhea and other diseases and disrupt your travel. Travelers to low or middle income destinations are especially at risk. Generally, foods served hot are usually safe to eat as well as dry and packaged foods. Bottled, canned, and hot drinks are usually safe to drink. Learn more about how to choose safer  food and drinks  to prevent getting sick.

Pregnant women should not use bismuth subsalicylate, which is in Pepto-Bismol and Kaopectate. Travelers to low or middle income  destinations  are more likely to get sick from food or drinks. Iodine tablets for water purification should not be used since they can harm thyroid development of the fetus.

After Travel

If you traveled and feel sick, particularly if you have a fever, talk to a healthcare provider immediately, and tell them about your travel. Avoid contact with other people while you are sick.

More Information

CDC Yellow Book: Pregnant Travelers

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List of Medications You Can and Can’t Take While Pregnant

• Safe Medications
• Possibly Unsafe Medications
• Unsafe Medications
• If You're Unsure

Certain medications are unsafe during pregnancy because they can cause severe congenital (at birth) disabilities and complications. This includes some medicines for pain and cold symptoms, among others. However, some medications are safe to take while pregnant.

About 9 in 10 pregnant people in the United States use over-the-counter (OTC) medication during their pregnancies, and 7 in 10 take prescription medication.

This article discusses medications that are safe during pregnancy and which are not, and how to know the difference. 

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The Food and Drug Administration (FDA) determines the safety of drugs. The rating system (called the Pregnancy and Lactation Labeling Rule) classifies medications with a general overview of how safe they are to use during pregnancy, breastfeeding, and for adults of reproductive age.  

List of Safe Medications to Take While Pregnant

Almost all pregnant people in the United States take at least one OTC or prescription medication during their pregnancies. The most common drugs are used for nausea , vomiting, heartburn , infection, and pain. Most commonly used medications are safe for a limited time during pregnancy, but it is always best to ask a healthcare provider first.

If you're pregnant, always check with a healthcare provider before taking any medication.

The following remedies for seasonal allergies are considered safe during pregnancy:

• Chlor-Trimeton (chlorpheniramine)
• Dexchlorpheniramine
• Atarax (hydroxyzine) 

Talk with a healthcare provider before taking the following allergy medications:  

• Benadryl (diphenhydramine)  
• Zyrtec (cetirizine)
• Claritin (loratadine)

Cold and Flu

You’ve likely heard that avoiding certain cold and flu medications is important when pregnant. Talk with your healthcare provider if you are unsure what to take. 

The following medications are considered safe during pregnancy:

• Cough drops 
• Saline nasal drops 
• Saltwater gargle 
• Tylenol (acetaminophen) 
• Mucinex (guaifenesin)
• Vicks VapoRub (menthol cream)

Avoid any long-acting or sustained-released types when choosing a cold or flu medication. 

Constipation

Constipation is a common problem during pregnancy because hormonal changes slow down the gastrointestinal tract. Most healthcare providers recommend increasing your water and fiber intake (fruits, vegetables, beans, whole grains) to help with this.

Medications that can help pregnancy-related constipation include:

• Citrucel (methylcellulose fiber)
• Metamucil (psyllium)
• Colace (docusate) 

COVID-19 Vaccine

All eligible people should receive the COVID-19 vaccine . Pregnant people can get this vaccine in any trimester.  

Heartburn is common during pregnancy and affects between 17% and 45% of pregnant people in the United States. Healthcare providers usually recommend treating it with diet and lifestyle changes, such as avoiding fatty foods, drinking enough water, and sleeping with your head elevated.  

Heartburn medications that are considered safe during pregnancy include:

• Ginger supplements 
• Tums (calcium carbonate)
• Mylanta (calcium carbonate)
• Maalox (aluminum hydroxide) 
• Pepcid AC (famotidine)
• Zantac 360 (famotidine)

Insect Repellent

Insect repellents with DEET (N, N-diethyl-meta-toluamide) provide adequate protection and are approved for use during pregnancy. Less than 10% of the DEET in insect repellents enters your bloodstream and reaches your baby.

Talk with your healthcare provider if you need to use insect repellent regularly during pregnancy.

Nausea and Vomiting

Nausea and vomiting is a common symptom, especially in the first trimester. Medications and supplements that are recommended for pregnancy-related nausea include:

• Ginger capsules or candies
• Unisom (doxylamine)

A healthcare provider may recommend trying a prescription medication if these remedies don't help.

Aches and pains are common during pregnancy. Most healthcare providers recommend Tylenol (acetaminophen) for minor aches and pains such as a headache or low-back pain. 

While nonsteroidal anti-inflammatory drugs (NSAIDs) , such as Advil (ibuprofen) and Aleve (naproxen) , can be taken during pregnancy, there are some slight risks. Speak with a healthcare provider before taking this medication.

Herbs and supplements can treat various conditions but may be unsafe during pregnancy. Ginger is safe for treating heartburn and nausea during pregnancy. For other herbs, talk with a healthcare provider. Some herbs known to be unsafe during pregnancy include:

• Evening primrose oil
• Blue cohosh 
• Raspberry oil 

List of Potentially Unsafe Medications While Pregnant 

Some medications are not safe for every pregnant person but can be used under the guidance of a healthcare provider. Some medicines are safe in one trimester but not others.

Sudafed (pseudoephedrine) carries a small risk of congenital disabilities in the abdominal wall in the first three months of pregnancy. Avoid this medication during your first trimester. Talk with your healthcare provider if you’d like to try it in your second or third trimester.  

If you continue to experience constipation despite diet and lifestyle changes, ask a healthcare provider about Miralax (polyethylene glycol 3350) . This medication is considered safe for occasional use during pregnancy.

Depression and Anxiety

Anxiety and depression medications cross the placenta, meaning they reach your baby while you are pregnant. They are also present in breast milk. Many selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants can be safely taken during pregnancy under a healthcare provider's guidance. These may include:

• Celexa (citalopram) 
• Zoloft (sertraline) 
• Lexapro (escitalopram) 
• Amitriptyline
• Nortriptyline 

Benzodiazepines are used to treat anxiety and insomnia. Studies show that they do not pose a serious risk to a fetus. Benzodiazepines that may be safe during pregnancy when taken in small doses include Valium (diazepam) and Xanax (alprazolam).

About 500,000 pregnant people in the United States experience psychiatric illness each year. It’s estimated that 10% to 16% of pregnant people meet the criteria for depression , and up to 70% have some symptoms of depression.  

List of Unsafe Medications to Not Take While Pregnant

While uncommon, certain medications have been linked to an increased risk of congenital disabilities, pregnancy loss, premature birth, and infant death. 

Nyquil is not recommended for pregnant or breastfeeding people because of its high alcohol content. 

Paxil (paroxetine) and Sinequan (doxepin) are not considered safe during pregnancy and have been linked to congenital disabilities.  It is possible for babies to experience withdrawal symptoms after being exposed to the following medications:

• Xanax (alprazolam)
• Librium (chlordiazepoxide)
• Valium (diazepam)

In most cases, opioid medications are not recommended for pregnant or breastfeeding people. These medications can significantly impact your baby's health and cause withdrawal symptoms after birth. However, medications might be needed at certain times, such as a serious injury or surgery.  

Common opioid medications include:

• Hydromorphone

Other prescription medications to treat chronic conditions may be unsafe during pregnancy. Never stop taking prescription medication without talking with a healthcare provider first. 

Some medications can be safely used during pregnancy but not breastfeeding, or vice versa. For example, it may be safe to take benzodiazepines for anxiety during pregnancy. However, this drug class can cause sedation and poor infant feeding when nursing.

Pregnancy-Safe Medications: If You’re Ever Unsure 

If you ever wonder if your medication is safe, always call a healthcare provider or pharmacist. They can review your overall health and individual risks to help you make the best decision for you and your baby. 

Knowing which medications are safe during pregnancy and breastfeeding is a challenge. Many commonly used drugs can be safely taken when you are pregnant. Always talk with a healthcare provider before starting a new medication or supplement. Some medicines can interact with each other or raise the risk of congenital disabilities and other serious pregnancy problems.

Centers for Disease Control and Prevention. Medicine and pregnancy .

U.S. Food and Drug Administration. Medicine and pregnancy .

Jin J. Safety of medications used during pregnancy . JAMA . 2022;328(5):486. doi:10.1001/jama.2022.8974

American College of Obstetricians and Gynecologists. What medicine can I take for allergies while I'm pregnant? .

American College of Obstetricians and Gynecologists. What can help with constipation during pregnancy? .

American College of Obstetricians and Gynecologists. COVID-19 vaccination considerations for obstetric–gynecologic care .

Vazquez JC. Heartburn in pregnancy . BMJ Clin Evid . 2015;2015:1411.

Ali RAR, Hassan J, Egan LJ. Review of recent evidence on the management of heartburn in pregnant and breastfeeding women . BMC Gastroenterol . 2022;22(1):219. doi:10.1186/s12876-022-02287-w

Insect Repellents . In: Mother To Baby | Fact Sheets . Brentwood (TN): Organization of Teratology Information Specialists (OTIS).

American College of Obstetricians and Gynecologists. Morning sickness: Nausea and vomiting of pregnancy .

Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea and vomiting of pregnancy . Obstet Gynecol . 2018;131(1):e15-e30. doi:10.1097/AOG.0000000000002456

American College of Obstetricians and Gynecologists. Medications for pain relief during labor and delivery .

Dante G, Bellei G, Neri I, Facchinetti F. Herbal therapies in pregnancy: what works? . Curr Opin Obstet Gynecol . 2014;26(2):83-91. doi:10.1097/GCO.0000000000000052

Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy . Gastroenterology . 2006;131(1):283-311. doi:10.1053/j.gastro.2006.04.049

ACOG Committee on Practice Bulletins--Obstetrics. Clinical management guidelines for obstetrician-gynecologists number 92, April 2008. Use of psychiatric medications during pregnancy and lactation . Obstet Gynecol . 2008;111(4):1001-1020. doi:10.1097/AOG.0b013e31816fd910

Ko JY, Tong VT, Haight SC, Terplan M, Snead C, Schulkin J. Obstetrician-gynecologists' practice patterns related to opioid use during pregnancy and postpartum-United States, 2017 . J Perinatol . 2020;40(3):412-421. doi:10.1038/s41372-019-0535-2

March of Dimes. Prescription medicine during pregnancy .

By Carrie Madormo, RN, MPH Madormo is a health writer with over a decade of experience as a registered nurse. She has worked in pediatrics, oncology, chronic pain, and public health.

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Motion Sickness During Pregnancy – Everything to Know

18 Jan 2024

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Motion sickness during pregnancy can be a challenging aspect of expecting mothers’ lives.

While the experience varies from woman to woman, understanding the causes, symptoms, and potential management strategies is crucial for those dealing with this discomfort.

This article provides a comprehensive overview of motion sickness during pregnancy, covering its definition, common triggers, symptoms, and practical measures to alleviate the unease.

Understanding Motion Sickness in Pregnancy

Motion sickness, often referred to as travel sickness, is a condition where an individual feels nauseous and dizzy when exposed to certain types of motion, such as traveling in a car, airplane, or boat.

During pregnancy, hormonal changes, particularly the increased levels of estrogen, can influence the susceptibility to motion sickness. The combination of altered hormonal balance and the physical changes occurring in the body can contribute to a heightened sensitivity to motion stimuli.

Causes of Motion Sickness During Pregnancy

Hormonal changes.

The primary driver behind motion sickness during pregnancy is the hormonal shift, specifically the rise in estrogen levels. This hormone affects the inner ear, a key component of the body’s balance system, leading to an increased likelihood of experiencing motion-related discomfort.

Physical Changes

As pregnancy progresses, the growing uterus exerts pressure on nearby organs, including the stomach. This physical change can contribute to feelings of nausea and discomfort, especially when subjected to motion.

Increased Sensitivity

Pregnant women may experience heightened sensitivity to various stimuli, including odors and motions. This heightened sensitivity can exacerbate the symptoms of motion sickness when exposed to certain environments or activities.

Symptoms of Motion Sickness in Pregnancy

• Nausea and Vomiting — The hallmark symptoms of motion sickness during pregnancy include nausea and, in some cases, vomiting. These symptoms can range from mild discomfort to more pronounced feelings of queasiness.
• Dizziness — Feelings of dizziness or lightheadedness are common manifestations of motion sickness. The altered balance mechanisms in the inner ear contribute to these sensations when exposed to motion.
• Sweating and Pallor — Some pregnant women experiencing motion sickness may notice increased sweating and a paler complexion. These physiological responses are the body’s reactions to the perceived stress associated with motion discomfort.

Managing Motion Sickness During Pregnancy

Choose the right mode of transportation.

Opting for modes of transportation that allow for a smoother ride can help minimize motion sickness. Consider choosing a larger, more stable vehicle or opting for a seat with minimal motion, such as the front seat in a car.

Stay Hydrated and Maintain a Light Diet

Dehydration can exacerbate feelings of nausea, so staying adequately hydrated is crucial. Additionally, maintaining a light diet and avoiding heavy or greasy meals before travel can help reduce the risk of motion sickness.

Focus on a Fixed Point

When in motion, focusing on a fixed point, such as the horizon, can help stabilize visual input and alleviate symptoms. This technique helps the brain reconcile conflicting signals from the inner ear and eyes.

Take Breaks and Get Fresh Air

Taking breaks during travel, especially on long journeys, allows for brief periods of rest and fresh air. Stepping outside and breathing in fresh air can contribute to a sense of relief from motion sickness.

Consultation with Healthcare Professionals

When to seek medical advice.

• While motion sickness during pregnancy is generally a temporary and manageable condition, seeking medical advice becomes essential in certain situations.
• If the symptoms are severe, persistent, or significantly impacting the well-being of the pregnant woman, consulting with a healthcare professional is advisable.
• Additionally, if there are concerns about the effects of motion sickness on the developing fetus or if there are pre-existing medical conditions, medical guidance should be sought.

Medication Considerations

Healthcare providers may recommend certain medications to alleviate motion sickness symptoms during pregnancy. However, the use of medications like a scopolamine patch prescription should be approached with caution, especially during the first trimester when the fetus is most vulnerable to potential adverse effects. Any medication, whether over-the-counter or prescription, should be discussed with a healthcare professional to ensure it is safe and appropriate for the specific circumstances.

Preventive Measures for Travel During Pregnancy

Plan travel during the second trimester.

The second trimester is often considered the most comfortable time for travel during pregnancy. By this stage, many women have passed the initial period of morning sickness, and the physical discomfort associated with the third trimester has not yet set in. Planning trips during this window can enhance the overall travel experience.

Consider Motion Sickness Bands

Acupressure bands, often worn around the wrists, are a non-invasive option to manage motion sickness. Some pregnant women find relief using these bands, which apply pressure to specific points believed to alleviate nausea and vomiting.

Travel During Off-Peak Hours

Choosing to travel during off-peak hours can contribute to a smoother experience. This may involve avoiding rush hours when traffic is heavy or selecting flights during less crowded times. Less crowded environments can reduce the overall sensory stimuli and minimize the risk of motion sickness.

Inform Travel Companions

Open communication with travel companions is crucial. Informing them about the potential for motion sickness and discussing strategies to make the journey more comfortable can foster understanding and support. Travel companions can play a significant role in creating a supportive environment during the trip.

Next, we will delve into additional considerations for pregnant individuals dealing with motion sickness, including self-care measures, the impact of multiple modes of transportation, and coping strategies that can be implemented during travel. By addressing these aspects comprehensively, pregnant women can equip themselves with practical insights for a smoother journey despite the challenges of motion sickness.

Coping Strategies and Self-Care During Travel

Ensuring proper ventilation during travel can be beneficial for pregnant individuals dealing with motion sickness. Fresh air can help alleviate feelings of nausea and create a more comfortable environment. When possible, open windows or choose modes of transportation with good airflow.

• Engaging in distraction techniques can redirect focus and alleviate symptoms. Bringing along entertainment such as books, music, or podcasts can be helpful.
• Additionally, focusing on conversation with travel companions or observing the surroundings can divert attention away from motion discomfort.
• Incorporating relaxation techniques into the travel routine can contribute to a calmer experience. Techniques such as deep breathing, guided imagery, or meditation can help manage stress and reduce the intensity of motion sickness symptoms.

Choosing loose, comfortable clothing for travel can enhance overall comfort. Tight or constrictive clothing may exacerbate feelings of nausea, so opting for breathable and relaxed attire is advisable.

Impact of Multiple Modes of Transportation

Combination of modes.

Travel itineraries involving a combination of transportation modes, such as a car followed by a boat or a plane, can increase the risk of motion sickness. The cumulative effect of different motions can intensify symptoms. Planning for breaks between modes of transportation and allowing time for the body to adjust can help mitigate this impact.

Choose Direct Routes

Opting for direct routes whenever possible can minimize the duration of travel and exposure to varying motions. Direct flights or non-stop car rides reduce the likelihood of experiencing motion sickness associated with multiple take-offs, landings, or changes in speed and direction.

Final Thoughts: Navigating Motion Sickness During Pregnancy

Motion sickness during pregnancy is a common challenge that many expectant mothers face. By understanding the causes, symptoms, and management strategies, pregnant individuals can navigate their journeys more comfortably. From practical measures like choosing the right mode of transportation and staying hydrated to preventive measures and self-care techniques, there are various strategies to alleviate motion sickness.

As each pregnancy is unique, it’s essential for pregnant individuals to tailor these strategies to their specific needs and consult with healthcare professionals when necessary. The second trimester may offer a more comfortable window for travel, and the use of acupressure bands or medication under medical guidance can provide additional support.

Open communication with travel companions, planning for breaks, and incorporating relaxation techniques are valuable tools for managing motion sickness. By adopting a proactive and informed approach, pregnant women can enhance their overall travel experience and focus on the positive aspects of their journey.

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Travel Sickness (Oral)

Generic name: meclizine [  MEK-li-zeen  ] Brand names: Antivert , Antivert/25, Antivert/50, Dramamine II , Meclicot , ... show all 9 brands Meni-D, Motion Sickness Relief, Simply Motion, Travel Sickness Drug class: Anticholinergic antiemetics

Medically reviewed by Drugs.com. Last updated on Jan 7, 2024.

Uses for Travel Sickness

Meclizine is used to prevent and control nausea, vomiting, and dizziness caused by motion sickness. It is also used for vertigo (dizziness or lightheadedness) caused by ear problems.

Meclizine is an antihistamine. It works to block the signals to the brain that cause nausea, vomiting, and dizziness.

This medicine is available only with your doctor's prescription.

Before using Travel Sickness

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies have not been performed on the relationship of age to the effects of Antivert® tablets and chewable tablets in children or Antivert®/25 or Antivert®/50 tablets in children younger than 12 years of age . Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of meclizine in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving meclizine.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Potassium Citrate
• Tranylcypromine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amifampridine
• Amobarbital
• Anileridine
• Benzhydrocodone
• Buprenorphine
• Butabarbital
• Butorphanol
• Calcium Oxybate
• Cannabidiol
• Chloral Hydrate
• Chlordiazepoxide
• Chlorpromazine
• Clorazepate
• Daridorexant
• Dexmedetomidine
• Dihydrocodeine
• Diphenhydramine
• Diphenoxylate
• Eszopiclone
• Ethchlorvynol
• Ethylmorphine
• Flibanserin
• Fospropofol
• Gabapentin Enacarbil
• Glycopyrrolate
• Glycopyrronium Tosylate
• Hydrocodone
• Hydromorphone
• Hydroxyzine
• Ketobemidone
• Lemborexant
• Levocetirizine
• Levorphanol
• Magnesium Oxybate
• Meprobamate
• Methacholine
• Methotrimeprazine
• Metoclopramide
• Morphine Sulfate Liposome
• Nicomorphine
• Opium Alkaloids
• Oxymorphone
• Papaveretum
• Pentazocine
• Pentobarbital
• Periciazine
• Phenobarbital
• Piritramide
• Potassium Oxybate
• Promethazine
• Propoxyphene
• Remimazolam
• Revefenacin
• Ropeginterferon Alfa-2b-njft
• Scopolamine
• Secobarbital
• Secretin Human
• Sodium Oxybate
• Thioridazine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Enlarged prostate or
• Glaucoma—Use with caution. May make these conditions worse.
• Kidney disease or
• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper use of Travel Sickness

Take this medicine only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Chew or crush the chewable tablet completely before swallowing. Do not swallow it whole.

Swallow the non-chewable tablet whole. Do not crush, chew, or break it.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• Adults—At first, 25 to 50 milligrams (mg) taken 1 hour before travel. You may take another dose once every 24 hours while traveling.
• Children 12 years of age and older—Use and dose must be determined by your doctor.
• Children younger than 12 years of age—Use is not recommended.
• Adults—25 to 100 milligrams (mg) per day, taken in divided doses.
• Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions while using Travel Sickness

It is very important that your doctor check your or your child's progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

This medicine may cause some people to become drowsy or less alert than they are normally. Do not drive or do anything else that could be dangerous until you know how this medicine affects you .

This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds, sedatives, tranquilizers, antidepressants, or sleeping medicine, prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your medical doctor or dentist before taking any of the above while you or your child are using this medicine .

Side Effects of Travel Sickness

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

• difficulty swallowing
• fast heartbeat
• hives, itching, skin rash
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• tightness in the chest
• unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Blurred vision

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Commonly used brand name(s)

In the U.S.

• Antivert/25
• Antivert/50
• Dramamine II
• Motion Sickness Relief
• Simply Motion
• Travel Sickness

Available Dosage Forms:

• Tablet, Chewable

Therapeutic Class: Antiemetic

Pharmacologic Class: Antihistamine

Chemical Class: Piperazine (class)

More about Travel Sickness (meclizine)

• Check interactions
• Compare alternatives
• Side effects
• Dosage information
• During pregnancy
• Drug class: anticholinergic antiemetics
• Breastfeeding

Patient resources

Other brands.

Antivert , Bonine , Dramamine Less Drowsy , Meclicot , ... +3 more

Professional resources

• Meclizine monograph
• Meclizine (FDA)

Related treatment guides

• Motion Sickness

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

promethazine , diphenhydramine , meclizine , Benadryl , Phenergan , scopolamine

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Motion sickness

Travel sickness.

Peer reviewed by Dr Hayley Willacy, FRCGP Last updated by Dr Colin Tidy, MRCGP Last updated 16 Mar 2023

Meets Patient’s editorial guidelines

In this series: Health advice for travel abroad Travelling to remote locations Ears and flying Jet lag Altitude sickness

Motion sickness (travel sickness) is common, especially in children. It is caused by repeated unusual movements during travelling, which send strong (sometimes confusing) signals to the balance and position sensors in the brain.

In this article :

What causes motion sickness, how long does motion sickness last, motion sickness symptoms, how to stop motion sickness, natural treatments for motion sickness, motion sickness medicines, what can a doctor prescribe for motion sickness, what should i do if i'm actually sick, what is mal de debarquement syndrome.

Continue reading below

Motion sickness is a normal response to repeated movements, such as going over bumps or around in a circle, send lots of messages to your brain. If you are inside a vehicle, particularly if you are focused on things that are inside the vehicle with you then the signals that your eyes send to the brain may tell it that your position is not changing, whilst your balance mechanisms say otherwise.

Your balance mechanisms in your inner ears sense different signals to those that your eyes are seeing which then sends your brain mixed, confusing messages. This confusion between messages then causes people to experience motion sickness.

Is motion sickness normal?

Motion sickness is a normal response that anyone can have when experiencing real or perceived motion. Although all people can develop motion sickness if exposed to sufficiently intense motion, some people are rarely affected while other people are more susceptible and have to deal with motion sickness very often.

Triggers for motion sickness

Motion sickness can also be triggered by anxiety or strong smells, such as food or petrol. Sometimes trying to read a book or a map can trigger motion sickness. Both in children and adults, playing computer games can sometimes cause motion sickness to occur.

Motion sickness is more common in children and also in women. Fortunately, many children grow out of having motion sickness. It is not known why some people develop motion sickness more than others. Symptoms can develop in cars, trains, planes and boats and on amusement park rides, etc.

Symptoms typically go when the journey is over; however, not always. In some people they last a few hours, or even days, after the journey ends.

There are various symptoms of motion sickness including::

Feeling sick (nausea and vomiting).

Sweating and cold sweats.

Increase in saliva.

Headaches .

Feeling cold and going pale.

Feeling weak.

Some general tips to avoid motion sickness include the following.

Prepare for your journey

Don't eat a heavy meal before travelling. Light, carbohydrate-based food like cereals an hour or two before you travel is best.

On long journeys, try breaking the journey to have some fresh air, drink some cold water and, if possible, take a short walk.

For more in-depth advice on travelling generally, see the separate leaflets called Health Advice for Travel Abroad , Travelling to Remote Locations , Ears and Flying (Aeroplane Ear) , Jet Lag and Altitude Sickness .

Plan where you sit

Keep motion to a minimum. For example, sit in the front seat of a car, over the wing of a plane, or on deck in the middle of a boat.

On a boat, stay on deck and avoid the cafeteria or sitting where your can smell the engines.

Breathe fresh air

Breathe fresh air if possible. For example, open a car window.

Avoid strong smells, particularly petrol and diesel fumes. This may mean closing the window and turning on the air conditioning, or avoiding the engine area in a boat.

Use your eyes and ears differently

Close your eyes (and keep them closed for the whole journey). This reduces 'positional' signals from your eyes to your brain and reduces the confusion.

Don't try to read.

Try listening to an audio book with your eyes closed. There is some evidence that distracting your brain with audio signals can reduce your sensitivity to the motion signals.

Try to sleep - this works mainly because your eyes are closed, but it is possible that your brain is able to ignore some motion signals when you are asleep.

Do not read or watch a film.

It is advisable not to watch moving objects such as waves or other cars. Don't look at things your brain expects to stay still, like a book inside the car. Instead, look ahead, a little above the horizon, at a fixed place.

If you are the driver you are less likely to feel motion sickness. This is probably because you are constantly focused on the road ahead and attuned to the movements that you expect the vehicle to make. If you are not, or can't be, the driver, sitting in the front and watching what the driver is watching can be helpful.

Treat your tummy gently

Avoid heavy meals and do not drink alcohol before and during travelling. It may also be worth avoiding spicy or fatty food.

Try to 'tame your tummy' with sips of a cold water or a sweet, fizzy drink. Cola or ginger ale are recommended.

Try alternative treatments

Sea-Bands® are acupressure bands that you wear on your wrists to put pressure on acupressure points that Chinese medicine suggests affects motion sickness. Some people find that they are effective.

Homeopathic medicines seem to help some people, and will not make you drowsy. The usual homeopathic remedy is called 'nux vom'. Follow the instructions on the packet.

All the techniques above which aim to prevent motion sickness will also help reduce it once it has begun. Other techniques, which are useful on their own to treat motion sickness but can also be used with medicines if required, are:

Breathe deeply and slowly and, while focusing on your breathing, listening to music. This has been proved to be effective in clinical trials.

Ginger - can improve motion sickness in some people (as a biscuit or sweet, or in a drink).

There are several motion sickness medicines available which can reduce, or prevent, symptoms of motion sickness. You can buy them from pharmacies or, in some cases, get them on prescription. They work by interfering with the nerve signals described above.

Medicines are best taken before the journey. They may still help even if you take them after symptoms have begun, although once you feel sick you won't absorb medicines from the stomach very well. So, at this point, tablets that you put against your gums, or skin patches, are more likely to be effective.

Hyoscine is usually the most effective medicine for motion sickness . It is also known as scopolamine. It works by preventing the confusing nerve messages going to your brain.

There are several brands of medicines which contain hyoscine - they also come in a soluble form for children. You should take a dose 30-60 minutes before a journey; the effect can last up to 72 hours. Hyoscine comes as a patch for people aged 10 years or over. (This is only available on prescription - see below.) Side-effects of hyoscine include dry mouth , drowsiness and blurred vision.

Side-effects of motion sickness medicines

Some medicines used for motion sickness may cause drowsiness. Some people are extremely sensitive to this and may find that they are so drowsy that they can't function properly at all. For others the effects may be milder but can still impair your reactions and alertness. It is therefore advisable not to drive and not to operate heavy machinery if you have taken them. In addition, some medicines may interfere with alcohol or other medication; your doctor or the pharmacist can advise you about this.

Antihistamines

Antihistamines can also be useful , although they are not quite as effective as hyoscine. However, they usually cause fewer side-effects. Several types of antihistamine are sold for motion sickness. All can cause drowsiness, although some are more prone to cause it than others; for example, promethazine , which may be of use for young children on long journeys, particularly tends to cause drowsiness. Older children or adults may prefer one that is less likely to cause drowsiness - for example, cinnarizine or cyclizine.

Remember, if you give children medicines which cause drowsiness they can sometimes be irritable when the medicines wear off.

See the separate article called How to manage motion sickness .

There are a number of anti-sickness medicines which can only be prescribed by your doctor. Not all of them always work well for motion sickness, and finding something that works may be a case of trial and error. All of them work best taken up to an hour before your journey, and work less well if used when you already feel sick. See also the separate leaflet called Nausea (Causes, Symptoms, and Treatment) for more detailed information about these medicines .

Hyoscine patch

Hyoscine, or scopolamine, patches are suitable for adults and for children over 10 years old. The medicine is absorbed through your skin, although this method of medicine delivery is slow so the patch works best if applied well before your journey.

You should stick the patch on to the skin behind the ear 5-6 hours before travelling (often this will mean late on the previous night) and remove it at the end of the journey.

Prochlorperazine

Prochlorperazine is a prescription-only medicine which works by changing the actions of the chemicals that control the tendency to be sick (vomit), in your brain. One form of prochlorperazine is Buccastem®, which is absorbed through your gums and does not need to be swallowed. Buccastem® tastes rather bitter but it can be effective for sickness when you are already feeling sick, as it doesn't have to be absorbed by the stomach.

Metoclopramide

Metoclopramide is a tablet used to speed up the emptying of your tummy. Slow emptying of the tummy is something that happens when you develop nausea and vomiting, so metoclopramide can help prevent this. It prevents nausea and vomiting quite effectively in some people. It can occasionally have unpleasant side-effects, particularly in children (in whom it is not recommended). Metoclopramide is often helpful for those who tend to have gastric reflux, those who have slow tummy emptying because of previous surgery, and those who have type 1 diabetes. Your GP will advise whether metoclopramide is suitable for you.

Domperidone

Domperidone , like metoclopramide, is sometimes used for sickness caused by slow tummy emptying. It is not usually recommended for motion sickness but is occasionally used if other treatments don't help. Domperidone is not a legal medicine in some countries, including the USA.

Ondansetron

Ondansetron is a powerful antisickness medicine which is most commonly used for sickness caused by chemotherapy, and occasionally used for morning sickness in pregnancy. It is not usually effective for motion sickness. This, and its relatively high cost means that it is not prescribed for motion sickness alone. However, for those undergoing chemotherapy, and for those who have morning sickness aggravated by travel, ondansetron may be helpful.

If you're actually sick you may find that this relieves your symptoms a little, although not always for very long. If you've been sick:

Try a cool flannel on your forehead, try to get fresh air on your face and do your best to find a way to rinse your mouth to get rid of the taste.

Don't drink anything for ten to twenty minutes (or it may come straight back), although (very) tiny sips of very cold water, coke or ginger ale may help.

After this, go back to taking all the prevention measures above.

Once you reach your destination you may continue to feel unwell. Sleep if you can, sip cold iced water, and - when you feel ready - try some small carbohydrate snacks. Avoid watching TV (more moving objects to watch!) until you feel a little better.

The sensation called 'mal de debarquement' (French for sickness on disembarking) refers to the sensation you sometimes get after travel on a boat, train or plane, when you feel for a while as though the ground is rocking beneath your feet. It is probably caused by the overstimulation of the balance organs during your journey. It usually lasts only an hour or two, but in some people it can last for several days, particularly after a long sea journey. It does not usually require any treatment.

Persistent mal de debarquement syndrome is an uncommon condition in which these symptoms may persist for months or years.

Dr Mary Lowth is an author or the original author of this leaflet.

Further reading and references

• Spinks A, Wasiak J ; Scopolamine (hyoscine) for preventing and treating motion sickness. Cochrane Database Syst Rev. 2011 Jun 15;(6):CD002851.
• Lackner JR ; Motion sickness: more than nausea and vomiting. Exp Brain Res. 2014 Aug;232(8):2493-510. doi: 10.1007/s00221-014-4008-8. Epub 2014 Jun 25.
• Leung AK, Hon KL ; Motion sickness: an overview. Drugs Context. 2019 Dec 13;8:2019-9-4. doi: 10.7573/dic.2019-9-4. eCollection 2019.
• Zhang LL, Wang JQ, Qi RR, et al ; Motion Sickness: Current Knowledge and Recent Advance. CNS Neurosci Ther. 2016 Jan;22(1):15-24. doi: 10.1111/cns.12468. Epub 2015 Oct 9.
• Van Ombergen A, Van Rompaey V, Maes LK, et al ; Mal de debarquement syndrome: a systematic review. J Neurol. 2016 May;263(5):843-854. doi: 10.1007/s00415-015-7962-6. Epub 2015 Nov 11.

Article History

The information on this page is written and peer reviewed by qualified clinicians.

Next review due: 14 Mar 2028

16 mar 2023 | latest version.

Last updated by

Peer reviewed by

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Travel sickness pills safe when pregnant?

There are herbal ones called Travella or something like that that the pharmacist said were safe when I went to Florida at 10weeks. Hope they work for you :) have a lovely time

I can highly recommend the sickness bands you get from any chemist, they are just called anti sickness bands £6 for 2 one for each wrist .

They cover travel sickness, morning sickness.

Hope this helps

Hi, I agree with Mandy, the Sea Bands that you can buy in places like Superdrug and Boots are great. I used them for the Plymouth to Roscoff sailing (six hours) when I was seven weeks pregnant and subsequently used them to help with morning sickness. I think I paid about £8 for the pair.

Charlotte (due 19 Oct)

Some travel sickness tablets, such as Phenergan, are actually also prescribed for morning sickness so they are reasonably safe (no drugs are classed as 100% safe in pregnancy and I think most would say to avoid unless discussed with your dr).

If yo'ure worried, try the Sea Bands which I've always found very good.

Pregnancy sickness (nausea and vomiting of pregnancy and hyperemesis gravidarum)

This information is for you if you want to know more about nausea and vomiting of pregnancy or about hyperemesis gravidarum, which is the most severe form of the condition. It may also be helpful if you are a relative or friend of someone who is in this situation.

The information here aims to help you better understand your health and your options for treatment and care. Your healthcare team is there to support you in making decisions that are right for you. They can help by discussing your situation with you and answering your questions.

Within this information we may use the terms ‘woman’ and ‘women’. However, we know that it is not only people who identify as women who may want to access this information. Your care should be appropriate, inclusive and sensitive to your needs whatever your gender identity.

A glossary of all medical terms is available .

• Nausea and vomiting of pregnancy is a common condition that settles by 20 weeks in 9 out of 10 pregnant women.
• Hyperemesis gravidarum is a severe form of this condition and can affect up to 3 in 100 pregnant women.
• Nausea and vomiting and hyperemesis gravidarum can affect your mood, your work, your home and your social life.
• While most women can be treated at home or as outpatients in hospitals, 1 in 5 affected women may need admission to hospital for treatment.
• Several different anti-sickness medicines are available that may help your symptoms. While some of these medicines may not be licensed for use in pregnancy, they are considered safe for you and your baby.

Nausea and vomiting are symptoms of pregnancy that affect most women. It starts early in pregnancy, usually between the 4th and 7th week. It settles by 20 weeks in 9 out of 10 women, although in some women it may last longer. It is often called ‘morning sickness’ but it can occur at any time of the day or night.

The cause is thought to be hormones which are produced in pregnancy in all women. Research suggests that some women get pregnancy sickness worse than others due to genetic differences, which causes them to have higher levels of a hormone called GDF-15. GDF-15 is a hormone produced by the placenta that causes a loss of appetite and nausea.

You are more likely to have pregnancy sickness if:

• you have had it before
• you are having more than one baby (twins or triplets)

It is important that other causes of vomiting are considered and looked into, particularly if:

• you have pain in your tummy or
• you have other symptoms for example pain passing urine
• you have had other medical conditions for example a stomach ulcer or gall stones, or
• your vomiting only starts after 16 weeks of pregnancy.

If the nausea and vomiting becomes so severe that it stops you from doing your daily activities and you are unable to eat and drink normally, it is known as hyperemesis gravidarum. This may affect up to 3 in 100 pregnant women.

It can cause you to become dehydrated. Signs of dehydration include feeling ‘dry’ or very thirsty, becoming drowsy or unwell, or your urine changing from a light yellow to a dark yellow or brown colour. Women with this condition may need to be admitted to hospital.

Nausea and vomiting of pregnancy can be a difficult problem to cope with. It can affect your mood, your work, your home situation and your social life. Support from family and friends can help. In some women, the symptoms can be so severe that they become depressed and need extra support such as counselling. If you find that you feel down then you should speak to your healthcare professional.

There is no evidence that mild to moderate nausea and vomiting have a harmful effect on your baby.

Women with severe nausea and vomiting or with hyperemesis gravidarum may have a baby with a lower than expected birthweight. You may be offered scans to monitor the growth of your baby.

Most women with nausea and vomiting of pregnancy will be able to manage their symptoms themselves. You could:

• eat small amounts of foods that are high in carbohydrate and low in fat, such as potato, rice and pasta, or foods that are easier to tolerate such as plain biscuits or crackers
• avoid any foods or smells that trigger symptoms.

If your symptoms do not settle or if they stop you doing your daily activities, see your GP. They can prescribe anti-sickness medication that is safe to take in pregnancy.

Contact your GP or your midwife. They will arrange for you to be seen in the assessment unit at your hospital. This may be in the maternity department or be part of the gynaecology unit. You can also get advice by contacting NHS 111.

You will be offered a check-up that may include:

• you are keeping fluids and food down
• you have tried any medication
• you have lost weight rapidly
• you have any other symptoms
• you have had this in a previous pregnancy
• a check of your general health including your temperature, pulse, breathing rate and blood pressure; you will be offered to have your weight measured and an assessment of whether you are dehydrated or undernourished.
• urine tests to look for infection
• blood tests
• an ultrasound scan if you have not had one yet in the pregnancy. This is to check how many weeks pregnant you are. It will also check for twins. If you are able to keep some fluids down but are unable to drink enough, you should be offered fluids through a drip in your arm over a short period of time. This is called rapid rehydration. You will also be offered anti-sickness medication. Many women feel much better after this and are able to go home.

Admission to hospital may be advised if you:

• are dehydrated
• have severe vomiting and are unable to keep any fluids or oral medication down
• have abnormal blood tests
• have lost a lot of weight rapidly
• have a medical condition such as a heart or kidney problem, diabetes, epilepsy or HIV and unable to take medicine orally.

You will be given fluids through a drip in your arm. This will be continued until you are able to drink fluids without vomiting.

Each day how much you drink and how much urine you are passing will be measured. Your temperature, blood pressure, pulse, breathing rate and weight will also be recorded.

You should be offered:

• anti-sickness medication and a B vitamin called thiamine. Both of these can be given through the drip in your arm if you are unable to keep tablets down
• special stockings (graduated elastic compression stockings) to help prevent blood clots.
• medication to reduce the acid in your stomach.
• heparin injections (to thin your blood). Pregnant women are at increased risk of developing blood clots in their legs, called deep vein thrombosis (DVT) or in their lungs (called pulmonary embolism). Being dehydrated and not being mobile increases this risk further. Heparin injections reduce this risk. You will be advised to continue these until you leave hospital and sometimes for longer. For further information, see the RCOG patient information Reducing the risk of venous thrombosis in pregnancy and after birth ( https://www.rcog.org.uk/for-the-public/browse-our-patient-information/reducing-the-risk-of-venous-thrombosis-in-pregnancy-and-after-birth-patient-information-leaflet/ )

If you are taking iron medication, this can be stopped temporarily because it can make sickness worse.

When you are feeling better, you can start to drink and eat small amounts and slowly build up to a normal diet.

There are several different types of anti-sickness medicines that you may be offered.

• An oral medication that is a slow-release combination of doxylamine and pyridoxine (vitamin B6) called Xonvea™ is the only licensed treatment of nausea and vomiting in pregnancy in the UK.
• Cyclizine can be taken by mouth or by an injection. Prochlorperazine, chlorpromazine and promethazine can also be tried if cyclizine has not worked.

All the medications above are considered to be safe in pregnancy. Occasionally, you may require a combination of two or more anti-sickness medications.

• Metoclopramide, domperidone and ondansetron are other medications that may be prescribed for nausea and vomiting and can be taken by mouth or by an injection. These are also considered safe to use in pregnancy. They are usually used if the previous medications have not worked. This is due to a small risk of side effects. Your health care professional can discuss this with you.
• you are still suffering from hyperemesis gravidarum despite fluids being given through a drip and regular anti-sickness medication has not helped
• you have lost a lot of weight.

Corticosteroids are successful in helping nausea and vomiting in many women where all other measures have not helped. Most women will be able to stop corticosteroids by 18–20 weeks but a few women will need to continue them at a low dose for the rest of the pregnancy. If you are taking corticosteroids, you will be offered a test for gestational diabetes.

If hyperemesis gravidarum is not treated, it may cause more harm to the baby than any possible effects of a medicine recommended by your doctor.

You will be offered anti-sickness tablets to take home. If you feel better, you can cut down the number of tablets. If your vomiting gets worse, you may put eating on hold but try to keep sipping fluids and taking the anti-sickness tablets until you start to feel better. Ask your GP for a repeat prescription before your tablets run out.

Your symptoms may return and you may become dehydrated. If this happens, contact your midwife, GP or maternity unit to be assessed again.

If you have ongoing severe nausea and vomiting after 20 weeks, contact your midwife or GP. They may offer you ultrasound scans to monitor the growth of your baby in later pregnancy.

Although this can be a difficult situation for you and may affect you throughout your pregnancy, the symptoms usually resolve or improve after your baby is born. If you have any ongoing concerns, contact your midwife or GP for advice and support.

Having pregnancy sickness can be stressful and can affect your mental wellbeing. If you are feeling anxious, depressed or worried in any way, please speak to your healthcare team who can answer your questions and help you get support. The support may come from healthcare professionals, voluntary organisations or other services. Further information and resources are available on the NHS website.

Further information

• NHS information on Nausea and morning sickness
• Pregnancy Sickness Support
• BUMPS: Best use of medicine in pregnancy
• Mental Health in pregnancy

If you are asked to make a choice, you may have lots of questions that you want to ask. You may also want to talk over your options with your family or friends. It can help to write a list of the questions you want answered and take it to your appointment.

Ask 3 Questions

To begin with, try to make sure you get the answers to  3 key questions , if you are asked to make a choice about your healthcare:

• What are my options?
• What are the pros and cons of each option for me?
• How do I get support to help me make a decision that is right for me?

*Ask 3 Questions is based on Shepherd et al. Three questions that patients can ask to improve the quality of information physicians give about treatment options: A cross-over trial. Patient Education and Counselling, 2011;84:379-85  

• https://aqua.nhs.uk/resources/shared-decision-making-case-studies/

Sources and acknowledgements

This information has been developed by the RCOG Patient Information Committee. It is based on the RCOG Green-top Clinical Guideline The Management of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum .

Please give us feedback by completing our feedback survey:

• Members of the public – patient information feedback
• Healthcare professionals – patient information feedback

Management of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum Green-top Guideline

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• Pregnancy week by week

Is it safe to fly during pregnancy?

Generally, air travel before 36 weeks of pregnancy is considered safe for people who aren't dealing with any pregnancy problems. Still, if you're pregnant, it's a good idea to talk with your health care provider before you fly.

Your provider might suggest that you not fly if you have certain pregnancy complications that could get worse because of air travel or that could require emergency care. Examples include a history of miscarriage or vaginal bleeding, severe anemia, and high blood pressure or diabetes that's not well controlled. If you had preeclampsia during a previous pregnancy — a condition that causes high blood pressure and extra protein in urine — flying may not be advised. The same is true if you're pregnant with twins or other multiples.

Tell your provider how far you are flying, as the length of the flight might make a difference. Also, be aware that some airlines may not allow pregnant people on international flights. Check with your airline before you make travel arrangements.

After 36 weeks of pregnancy, your health care provider may advise against flying. And some airlines don't allow pregnant people to fly after 36 weeks. The airline also may require a letter from your health care provider that states how far along in your pregnancy you are and whether flying is advised.

If your health care provider says it's okay for you to fly, and your plans are flexible, the best time to travel by air might be during the second trimester. The risks of common pregnancy emergencies are lowest during that time.

When you fly:

• Buckle up. During the trip, keep your seatbelt fastened when you are seated, and secure it under your belly.
• Drink plenty of fluids. Low humidity in the airplane could cause you to become dehydrated.
• Avoid gassy foods and drinks before you fly. Gases expand during flight, and that could make you uncomfortable. Examples of foods and drinks to avoid include broccoli and carbonated soda.
• Think about medical care. Plan for how you'll get obstetric care during your trip if you need it. Bring copies of your medical information in case you need care while you're away.

Blood clots

Air travel can raise the risk for blood clots in the legs, a condition called venous thrombosis. The risk is higher for pregnant people. Moving your legs may help prevent this problem. Take a walk up and down the aisle every hour during the flight. If you must remain seated, flex and extend your ankles from time to time. In general, it's best to avoid tightfitting clothing, as that can hinder blood flow. Wearing compression stockings can help with blood circulation during a long flight.

Radiation exposure linked to air travel at high altitudes isn't thought to be a problem for most people who fly during pregnancy. But pilots, flight attendants and others who fly often might be exposed to a level of radiation that raises concerns during pregnancy. If you must fly frequently during your pregnancy, talk about it with your health care provider.

Mary Marnach, M.D.

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• Allergy medications during pregnancy
• AskMayoExpert. Health considerations for air travelers: Pregnancy considerations. Mayo Clinic; 2022.
• Air Travel During Pregnancy: ACOG Practice Bulletin No. 746. American College of Obstetricians and Gynecologists. https://www.acog.org/clinical/clinical-guidance/committee-opinion/articles/2018/08/air-travel-during-pregnancy. Accessed Dec. 1, 2022.
• Ram S, et al. Air travel during pregnancy and the risk of venous thrombosis. American Journal of Obstetrics and Gynecology. 2022; doi:10.1016/j.ajogmf.2022.100751.

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Brand name: Valoid. Find out how cyclizine treats nausea and vomiting, and how to take it.

• About cyclizine
• Who can and cannot take it
• How and when to take it
• Side effects
• Pregnancy, breastfeeding and fertility
• Taking cyclizine with other medicines and herbal supplements
• Common questions

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